2-氯-3-氨基-4-溴吡啶 | 1354021-09-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-氯-3-氨基-4-溴吡啶
• 中文别名: 4-溴-2-氯吡啶-3-胺
• 英文名称: 4-bromo-2-chloropyridin-3-amine
• CAS: 1354021-09-2
• 化学式: C₅H₄BrClN₂
• 分子量: 207.457
• InChiKey: BKNJTGQNJXCFGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-氯-3-氨基-4-溴吡啶 在 咪唑 、 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 palladium 10% on activated carbon 、 氢气 、 potassium carbonate 、 三乙胺 作用下， 以 1,4-二氧六环 、 甲醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 11.0h， 生成 4-(2-(1-(((tert-butyldimethylsilyl)oxy)methyl)cyclopropyl)ethyl)-2-isopropylpyridin-3-amine
  参考文献：
  名称：

  Small Molecule Inhibitors of KRAS G12C Mutant

  摘要：

  该披露提供了Formula (I)的化合物或其药用盐，其中W1、W2、Y、Z、M、L、Cy、Cz、R1、R2、R3、R4、R2a、Ry、Rz以及下标m、n、q和r如本文所述。这些化合物或其药用盐可以抑制Kirsten大鼠肉瘤（KRAS）蛋白的G12C突变体，并有望作为治疗剂具有用途，例如用于治疗癌症。该披露还提供了包含Formula (I)的化合物或其药用盐的药物组合物。该披露还涉及使用这些化合物或其药用盐在癌症的治疗和预防中的方法，以及为此目的制备药物。

  公开号：

  US20210122764A1

文献信息

• NOVEL COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME
  申请人：LG CHEM, LTD.

  公开号：US20200313098A1

  公开（公告）日：2020-10-01

  Provided is a compound of Chemical Formula 1: wherein: among X 1 to X 4 , one of X 1 and X 2 , X 2 and X 3 , or X 3 and X 4 are linked with * in the following Chemical Formula 2, and of the remaining two, one is hydrogen, and the other is R 3 : R 1 and R 2 are each independently hydrogen, deuterium, halogen, cyano, amino, a substituted or unsubstituted C 1-60 alkyl, a substituted or unsubstituted C 1-60 haloalkyl, a substituted or unsubstituted C 1-60 alkoxy, a substituted or unsubstituted C 1-60 haloalkoxy, a substituted or unsubstituted C 3-60 cycloalkyl, a substituted or unsubstituted C 2-60 alkenyl, a substituted or unsubstituted C 6-60 aryl, a substituted or unsubstituted C 6-60 aryloxy, or a substituted or unsubstituted C 2-60 heterocyclic group containing one or more heteroatoms selected from the group consisting of N, O and S; one of R 3 is hydrogen, and the other is —Si(R 4 )(R 5 )(R 6 ), R 4 to R 6 are each independently hydrogen, deuterium, cyano, a substituted or unsubstituted C 1-60 alkyl, a substituted or unsubstituted C 3-60 cycloalkyl, a substituted or unsubstituted C 6-60 aryl, or a substituted or unsubstituted C 2-60 heteroaryl containing at least one selected from the group consisting of N, O and S; and n is an integer of 0 to 2, and an organic light emitting device including the same.
• [EN] SMALL MOLECULE INHIBITORS OF KRAS G12C MUTANT<br/>[FR] INHIBITEURS À PETITES MOLÉCULES DE MUTANT DE KRAS G12C
  申请人：[en]MERCK SHARP & DOHME CORP.

  公开号：WO2021086833A1

  公开（公告）日：2021-05-06

  The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein W1, W2, Y, Z, M, L, Cy, Cz, R1, R2, R3, R4, R2a, Ry, Rzand the subscripts m, n, q, and r are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.
• [EN] NOVEL COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT COMPRISING SAME<br/>[FR] NOUVEAU COMPOSÉ ET ÉLÉMENT ÉLECTROLUMINESCENT ORGANIQUE LE COMPRENANT<br/>[KO] 신규한 화합물 및 이를 이용한 유기 발광 소자
  申请人：LG CHEMICAL LTD

  公开号：WO2021235906A1

  公开（公告）日：2021-11-25

  본 발명은 신규한 화합물 및 이를 이용한 유기발광 소자를 제공한다.