Ethyl 2-amino-2,3,4,5,6,7-hexahydro-1-benzothiophene-3-carboxylate | 1421278-55-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ethyl 2-amino-2,3,4,5,6,7-hexahydro-1-benzothiophene-3-carboxylate
• CAS: 1421278-55-8
• 化学式: C₁₁H₁₇NO₂S
• 分子量: 227.327
• InChiKey: DHBJPEQNJHPSCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  77.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Ethyl 2-amino-2,3,4,5,6,7-hexahydro-1-benzothiophene-3-carboxylate 在 溶剂黄146 、 sodium nitrite 、 一水合肼 作用下， 以 二氯甲烷 为溶剂， 反应 0.75h， 以75%的产率得到Ethyl 2-azido-2,3,4,5,6,7-hexahydro-1-benzothiophene-3-carboxylate
  参考文献：
  名称：

  One pot synthesis of aromatic azide using sodium nitrite and hydrazine hydrate

  摘要：

  A simple, rapid, and efficient protocol for the synthesis of aryl azide using sodium nitrite and hydrazine hydrate at room temperature is discussed. The short reaction time, simple work-up procedure, and use of inexpensive reagents are advantages of this method. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.12.112

文献信息

• [EN] TRICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS TRICYCLIQUES AYANT UNE ACTIVITÉ ANTIMITOTIQUE ET/OU ANTITUMORALE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV HOLY GHOST DUQUESNE

  公开号：WO2010006032A1

  公开（公告）日：2010-01-14

  The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxal sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.