alstopirocine | 1253212-09-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: alstopirocine
• 英文别名: 3,4-dihydroxy-1-[4-[(1S,12S,13R,14R)-13-(hydroxymethyl)-3,16-dimethyl-3,16-diazatetracyclo[10.3.1.02,10.04,9]hexadeca-2(10),4,6,8-tetraen-14-yl]-5-methyl-1H-pyrrol-2-yl]butan-1-one
• CAS: 1253212-09-7
• 化学式: C₂₆H₃₃N₃O₄
• 分子量: 451.566
• InChiKey: GXPRFZZMNRUCBA-OMZFOGPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  102
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  alstopirocine 、 乙酸酐 在 吡啶 作用下， 反应 2.0h， 以50%的产率得到alstopirocine triacetate
  参考文献：
  名称：

  Unusual indole alkaloid–pyrrole, –pyrone, and –carbamic acid adducts from Alstonia angustifolia

  摘要：

  Three unusual natural products, viz., alstopirocine, a macroline alkaloid incorporating a substituted pyrrole moiety, pleiomaltinine, an alkaloid-pyrone adduct, and pleiomalicine, an alkaloid-carbamic acid adduct, were isolated from the Malayan Alstonia angustifolia. The alkaloid moiety in alstopirocine was alstomicine while that in pleiomaltinine and pleiomalicine was pleiocarpamine. The structures were determined by spectroscopic methods and in the case of pleiomaltinine, confirmed by X-ray diffraction analysis. Possible biogenetic pathways to these unusual compounds are presented. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.07.079