(2R,3S,4R,5S)-1,3,4,5-tetrakis(phenylmethoxy)heptane-2,6-diol | 1233196-40-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R,3S,4R,5S)-1,3,4,5-tetrakis(phenylmethoxy)heptane-2,6-diol
• CAS: 1233196-40-1
• 化学式: C₃₅H₄₀O₆
• 分子量: 556.699
• InChiKey: ODPJPIINNVNMTM-QSWKYAHNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  41
• 可旋转键数：
  17
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  77.4
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2R,3S,4R,5S)-1,3,4,5-tetrakis(phenylmethoxy)heptane-2,6-diol 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以84%的产率得到3,4,5,7-tetra-O-benzyl-1-deoxy-L-arabino-hepto-2,6-diulose
  参考文献：
  名称：

  Short synthesis of a benzyl ether-protected building block for the synthesis of carbocyclic galactopyranose mimics

  摘要：

  A versatile intermediate for the synthesis of galactose-mimicking carbasugars was synthesised from tetrabenzyl galactose in five steps and 30% overall yield. The reaction sequence uses an L-proline mediated aldol reaction as key step The reaction sequence was run on several grams of material. (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.carres.2010.03.030
• 作为产物：
  描述：

  2,3,4,6-四-O-苄基-D-吡喃半乳糖 、 甲基溴化镁 以 四氢呋喃 、 甲苯 为溶剂， 以97%的产率得到(2R,3S,4R,5S)-1,3,4,5-tetrakis(phenylmethoxy)heptane-2,6-diol
  参考文献：
  名称：

  Short synthesis of a benzyl ether-protected building block for the synthesis of carbocyclic galactopyranose mimics

  摘要：

  A versatile intermediate for the synthesis of galactose-mimicking carbasugars was synthesised from tetrabenzyl galactose in five steps and 30% overall yield. The reaction sequence uses an L-proline mediated aldol reaction as key step The reaction sequence was run on several grams of material. (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.carres.2010.03.030