(+)-(2S,3R)-3-azido-2-hydroxy-3-(4-phenylthiophen-2-yl)propionic acid ethyl ester | 1208246-63-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (+)-(2S,3R)-3-azido-2-hydroxy-3-(4-phenylthiophen-2-yl)propionic acid ethyl ester
• 英文别名: ethyl (2S,3R)-3-azido-2-hydroxy-3-(4-phenylthiophen-2-yl)propanoate
• CAS: 1208246-63-2
• 化学式: C₁₅H₁₅N₃O₃S
• 分子量: 317.368
• InChiKey: VWDAQBCAZYCUNH-KBPBESRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  89.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (+)-(2S,3R)-3-azido-2-hydroxy-3-(4-phenylthiophen-2-yl)propionic acid ethyl ester 在 dimethyl sulfide borane 、 sodium tetrahydroborate 、 甲醇 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以70%的产率得到(+)-(2S,3R)-3-azido-3-(4-phenylthiophen-2-yl)propane-1,2-diol
  参考文献：
  名称：

  Synthesis of New Thienyl Ring Containing HIV-1 Protease Inhibitors: Promising Preliminary Pharmacological Evaluation against Recombinant HIV-1 Proteases

  摘要：

  A series of new thienyl ring containing analogues of nelfinavir and saquinavir with different Substitution patterns were synthesized from suitable enantiopure diols. Their inhibitory activity against wild type recombinant HIV-1 protease was evaluated. In general thienyl groups spaced from the core by a methylene group gave products showing IC(50) in the nanomolar range, Irrespective of the type and the substitution pattern of the heterocycle. The range of activity of the two most active compounds is substantially maintained or even Increased against two commonly selected mutants, under drug pressure, Such as V32I and V82A.

  DOI：

  10.1021/jm900846f
• 作为产物：
  描述：

  2-oxo-5-(4-phenylthiophen-2-yl)-1,3,2-dioxathiolane-4-carboxylic acid ethyl ester 在 sodium azide 、 硫酸 、 水 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 16.0h， 以80%的产率得到(+)-(2S,3R)-3-azido-2-hydroxy-3-(4-phenylthiophen-2-yl)propionic acid ethyl ester
  参考文献：
  名称：

  Synthesis of New Thienyl Ring Containing HIV-1 Protease Inhibitors: Promising Preliminary Pharmacological Evaluation against Recombinant HIV-1 Proteases

  摘要：

  A series of new thienyl ring containing analogues of nelfinavir and saquinavir with different Substitution patterns were synthesized from suitable enantiopure diols. Their inhibitory activity against wild type recombinant HIV-1 protease was evaluated. In general thienyl groups spaced from the core by a methylene group gave products showing IC(50) in the nanomolar range, Irrespective of the type and the substitution pattern of the heterocycle. The range of activity of the two most active compounds is substantially maintained or even Increased against two commonly selected mutants, under drug pressure, Such as V32I and V82A.

  DOI：

  10.1021/jm900846f

文献信息

• Synthesis of New Thienyl Ring Containing HIV-1 Protease Inhibitors: Promising Preliminary Pharmacological Evaluation against Recombinant HIV-1 Proteases
  作者：Carlo Bonini、Lucia Chiummiento、Margherita De Bonis、Nadia Di Blasio、Maria Funicello、Paolo Lupattelli、Rocco Pandolfo、Francesco Tramutola、Federico Berti

  DOI：10.1021/jm900846f

  日期：2010.2.25

  A series of new thienyl ring containing analogues of nelfinavir and saquinavir with different Substitution patterns were synthesized from suitable enantiopure diols. Their inhibitory activity against wild type recombinant HIV-1 protease was evaluated. In general thienyl groups spaced from the core by a methylene group gave products showing IC(50) in the nanomolar range, Irrespective of the type and the substitution pattern of the heterocycle. The range of activity of the two most active compounds is substantially maintained or even Increased against two commonly selected mutants, under drug pressure, Such as V32I and V82A.