1-(4-(烯丙氧基)-3,5-二甲氧基苯基)丙烷-2-胺 | 214414-87-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(4-(烯丙氧基)-3,5-二甲氧基苯基)丙烷-2-胺
• 英文名称: 2-[3,5-Dimethoxy-4-(prop-2-enyloxy)phenyl]-1-methylethylamin
• 英文别名: 4-allyloxy-3,5-dimethoxyamphetamine；1-(4-(Allyloxy)-3,5-dimethoxyphenyl)propan-2-amine；1-(3,5-dimethoxy-4-prop-2-enoxyphenyl)propan-2-amine
• CAS: 214414-87-6
• 化学式: C₁₄H₂₁NO₃
• 分子量: 251.326
• InChiKey: ROINMNZLTKSBPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  53.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-(allyloxy)-3,5-dimethoxybenzaldehyde 在 lithium aluminium tetrahydride 、 硫酸 、 溶剂黄146 、 正丁胺 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 1-(4-(烯丙氧基)-3,5-二甲氧基苯基)丙烷-2-胺
  参考文献：
  名称：

  摘要：

  The synthesis and the spectroscopic data of 14 novel 4-substituted mescaline derivatives are reported. Starting from syringalclehyde (=4-hydroxy-3,5-dimethoxybenzaldehyde). several ethers were obtained from reaction with a series of corresponding saturated and unsaturated alkyl- and fluoroalkyl halides. Henry-reaction with MeNO2 or EtNO2 followed to afford the nitro-olefines, which were then reduced with AlH3 to the desire(d) 2-phenylethyl- and 1-methyl-2-phenylethylamine derivatives.

  DOI：

  10.1002/1522-2675(200209)85:9<3019::aid-hlca3019>3.0.co;2-4

文献信息

• Antiparkinsonian Action of Phenylisopropylamines
  申请人：Caron G. Marc

  公开号：US20070027208A1

  公开（公告）日：2007-02-01

  A method of treating a subject for Parkinson's disease comprises administering said subject a phenylisopropylamine in an amount effective to treat said Parkinson's disease. In some embodiments the method is used to treat at least a motor symptom of Parkinson's disease; in some embodiments the method is used to treat at least a non-motor symptom of Parkinson's disease.
• US8877802B2
  申请人：——

  公开号：US8877802B2

  公开（公告）日：2014-11-04
• [EN] ANTIPARKINSONIAN ACTION OF PHENYLISOPROPYLAMINES<br/>[FR] ACTION ANTIPARKINSONIENNE DE PHENYLISOPROPYLAMINES
  申请人：UNIV DUKE

  公开号：WO2007016190A2

  公开（公告）日：2007-02-08

  [EN] A method of treating a subject for Parkinson's disease comprises administering said subject a phenylisopropylamine in an amount effective to treat said Parkinson's disease. In some embodiments the method is used to treat at least a motor symptom of Parkinson's disease; in some embodiments the method is used to treat at least a non-motor symptom of Parkinson's disease.
  [FR] L'invention concerne une méthode pour traiter un patient présentant la maladie de Parkinson. Cette méthode consiste à administrer à ce patient une phénylisopropylamine dans une quantité efficace pour traiter ladite maladie de Parkinson. Dans certains modes de réalisation, la méthode est utilisée pour traiter au moins un symptôme moteur de la maladie de Parkinson. Dans d'autres modes de réalisation de la méthode de l'invention, cette méthode est utilisée pour traiter au moins un symptôme non moteur de la maladie de Parkinson.
• ——
  作者：Daniel Trachsel

  DOI：10.1002/1522-2675(200209)85:9<3019::aid-hlca3019>3.0.co;2-4

  日期：2002.9

  The synthesis and the spectroscopic data of 14 novel 4-substituted mescaline derivatives are reported. Starting from syringalclehyde (=4-hydroxy-3,5-dimethoxybenzaldehyde). several ethers were obtained from reaction with a series of corresponding saturated and unsaturated alkyl- and fluoroalkyl halides. Henry-reaction with MeNO2 or EtNO2 followed to afford the nitro-olefines, which were then reduced with AlH3 to the desire(d) 2-phenylethyl- and 1-methyl-2-phenylethylamine derivatives.