1-(4-(溴甲基)苯基磺酰基)-4-(溴甲基)苯 | 4542-76-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(4-(溴甲基)苯基磺酰基)-4-(溴甲基)苯
• 英文名称: 4,4'-sulfonyl bis(bromomethyl)-benzene
• 英文别名: Bis[4-(bromomethyl)phenyl] sulfone；1-(bromomethyl)-4-[4-(bromomethyl)phenyl]sulfonylbenzene
• CAS: 4542-76-1
• 化学式: C₁₄H₁₂Br₂O₂S
• 分子量: 404.122
• InChiKey: UPEZCZHEUGNPOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-(溴甲基)苯基磺酰基)-4-(溴甲基)苯 在 氢氧化钾 、 氯化亚砜 、 四丁基溴化铵 作用下， 以 N-甲基吡咯烷酮 、 水 为溶剂， 反应 8.0h， 生成 di{4-[(2-chlorocarbonylphenyloxy)methyl]phenyl}sulfone
  参考文献：
  名称：

  环状聚合物的合成：环状S-二硫酯与硫烷的扩环反应

  摘要：

  在TBAC作为催化剂存在下，在NMP中检测了等摩尔环状二硫酸酯1与3-苯氧丙烯硫化物（PPS）的扩环反应（环状二硫酸酯1 / PPS = 1/2）。发现在PPS插入环状二硫酯的插入反应过程中发生了分子间酯交换反应，并以80-96％的产率获得了M n s = 3600-8900的环状聚合物。通过1 H NMR，13 C NMR IR和MALDI TOF-MS光谱确认所获得的环状聚合物的结构。过量的PPS连续插入环状二硫代酸酯中（环状二硫代酸酯1还检查了/ PPS ＝ 1/50），发现插入反应定量地进行，以96％的收率得到了相应的环状多硫化物，其M n＝ 42000，M w / M n＝ 4.50。

  DOI：

  10.1021/ma047642h
• 作为产物：
  描述：

  N,N-bis(p-tolyl)acetamide 在 叔丁基过氧化氢 、 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氯化碳 为溶剂， 生成 1-(4-(溴甲基)苯基磺酰基)-4-(溴甲基)苯
  参考文献：
  名称：

  Synthesis and Structure–Activity Analysis of New Phosphonium Salts with Potent Activity against African Trypanosomes

  摘要：

  A series of 73 bisphosphonium salts and 10 mono-phosphonium salt derivatives were synthesized and tested in vitro against several wild type and resistant lines of Trypanosoma brucei (T. b. rhodesiense STIB900, T. b. brucei strain 427, TbAT1-KO, and TbB48). More than half of the compounds tested showed a submicromolar EC50 against these parasites. The compounds did not display any cross-resistance to existing diamidine therapies, such as pentamidine. In most cases, the compounds displayed a good selectivity index versus human cell lines. None of the known T. b. brucei drug transporters were required for trypanocidal activity, although some of the bisphosphonium compounds inhibited the low affinity pentamidine transporter. It was found that phosphonium drugs act slowly to clear a trypanosome population but that only a short exposure time is needed for irreversible damage to the cells. A comparative molecular field analysis model (CoMFA) was generated to gain insights into the SAR of this class of compounds, identifying key features for trypanocidal activity.

  DOI：

  10.1021/jm2014259

文献信息

• Immobilized Pd on a NHC-functionalized metal-organic FrameworkMIL-101(Cr): An efficient heterogeneous catalyst in the heck and copper-free Sonogashira coupling reactions
  作者：Esmaeil Niknam、Farhad Panahi、Ali Khalafi-Nezhad

  DOI：10.1016/j.jorganchem.2020.121676

  日期：2021.3

  using various microscopic and spectroscopic techniques and then was used as an efficient heterogeneous Pd catalyst system in the Heck and copper-free Sonogashira reactions. Results of the heterogeneity tests showed that the Pd-NHC-MIL-101(Cr) catalyst can efficiently catalyzed these coupling reactions heterogeneously and no remarkable changes observed in the morphology and structure of MIL-101(Cr) template

  基于钯部分固定在N上的非均相钯催化剂体系-杂环卡宾（NHC）改性的金属有机骨架（MOF）被开发用于Heck和无铜Sonogashira偶联反应。为了制备该催化剂体系，首先，通过后合成修饰（PSM）方法用NHC部分将MIL-101（Cr）官能化，然后将Pd金属稳定在预先制成的MIL-101（Cr）-NHC基底上。使用多种显微镜和光谱技术对该材料进行了表征，然后将其用作Heck和无铜Sonogashira反应中的高效多相Pd催化剂体系。非均质性测试结果表明，Pd-NHC-MIL-101（Cr）催化剂能够有效地异质催化这些偶联反应，并且在反应过程中未观察到MIL-101（Cr）模板的形态和​​结构发生明显变化。也，TEM和XPS分析证实了固定在MOF结构上的钯纳米粒子的存在证实了Pd的氧化态。在正常条件下，使用这种非均相钯催化剂体系，可以以高至极好的收率合成各种烯烃和炔烃衍生物。更重要的是，Pd
• Synthesis and photovoltaic properties of novel solution-processable triphenylamine-based dendrimers with sulfonyldibenzene cores
  作者：Kunpeng Li、Jiali Qu、Bin Xu、Yinhua Zhou、Leijing Liu、Ping Peng、Wenjing Tian

  DOI：10.1039/b9nj00236g

  日期：——

  Three conjugated dendrimers containing electron-accepting sulfonyldibenzene (SDB) cores and electron-donating triphenylamine dendrons have been synthesized through a convergent synthetic strategy without any protection/deprotection chemistry. The dendrimers were highly soluble in common organic solvents, and could form good quality optical films by spin coating. Their thermal, optical and electrical properties are manipulated by attaching different peripheral dendrons. Using these dendrimers as donors and [6,6]-phenyl C61-butyric acid methyl ester (PCBM) as acceptor, the bulk heterojunction solar cells with a structure of ITO–PEDOT–dendrimers:PCBM–LiF–Al were fabricated. The cell based on dendrimer G0 shows a relatively high power-conversion efficiency (PCE) of 0.34% under AM 1.5 illumination of 100 mW cm−2.

  合成了三种含有电子受体硫氧基二苯（SDB）核心和电子给体三苯胺树状结构的共轭树枝状聚合物，采用了不需要任何保护/去保护化学反应的聚合物汇聚合成策略。这些树枝状聚合物在常见有机溶剂中具有高度的溶解性，并能通过旋涂形成高质量的光学薄膜。通过连接不同的外部树枝状结构，可调控其热学、光学和电学性质。以这些树枝状聚合物为供体，[6,6]-苯基C61-丁酸甲酯（PCBM）为受体，制备了结构为ITO–PEDOT–树枝状聚合物:PCBM–LiF–Al 的薄膜异质结太阳能电池。基于树枝状聚合物G0的电池在100 mW cm−2的AM 1.5照射下，显示出相对较高的光电转化效率（PCE）为0.34%。
• Synthesis of benzothiazole–benzoxazole dendrimers with triazole as bridging unit and their application in dye-sensitized solar cells
  作者：Perumal Rajakumar、Venkatesan Kalpana、Shanmugam Ganesan、Pichai Maruthamuthu

  DOI：10.1039/c3nj00887h

  日期：——

  Dendrimers with benzothiazole–benzoxazole surface groups and electron transporting triazole as bridging units and diphenyl sulfone as core unit were synthesized successfully by Cu(I)-catalysed Huisgen ‘click reaction’ using a convergent approach. All the dendrimers exhibit excellent optical and electrochemical properties. Higher-generation dendrimers exhibit better current generating capacity and show

  树枝状聚合物 苯并噻唑–苯并恶唑 表面基团和电子传输 三唑 作为桥接单元和 二苯砜作为核心单元，是通过Cu（I）催化的Huisgen“点击反应”使用收敛方法成功合成的。所有的树枝状聚合物均表现出优异的光学和电化学性能。当用作染料敏化太阳能电池的添加剂时，较高代的树枝状聚合物显示出比较低代的树枝状聚合物更好的电流产生能力和更好的功率转换效率。
• Compounds
  申请人：Gore Paul Martin

  公开号：US20090270355A1

  公开（公告）日：2009-10-29

  The present invention relates to a compound which is N-(4-4-[(6-butyl-8-quinolinyl)oxy]-1-piperidinyl}butyl)ethanesulfonamide and salts thereof, processes for its preparation, to compositions containing it and to its use in the treatment of various diseases, such as allergic rhinitis.

  本发明涉及一种化合物，即N-(4-4-[(6-丁基-8-喹啉基)氧基]-1-哌啶基}丁基)乙烷磺酰胺及其盐，以及其制备方法、含有该化合物的组合物，以及在治疗各种疾病（如过敏性鼻炎）中的用途。
• Thiocarbonylthio compound and free radical polymerization employing the same
  申请人：Shih Chen Kuo

  公开号：US20060270867A1

  公开（公告）日：2006-11-30

  A thiocarbonylthio compound and free radical polymerization employing the same. The thiocarbonylthio compound is represented by formula (I) or (II): wherein Z can be independently perfluoroalkyl, alkyl, haloalkyl, aryl, alkylaryl, haloalkylaryl, arylalkyl, aminoalkyl, alkylamino, alkoxy, alkoxyaryl, alkylsulfonyl, alkylsulfonylaryl, dialkylphosphinyl, or dialkylphosphinothioyl; R 1 and R 2 can be each independently hydrogen, alkyl, aryl, alkylaryl, arylalkyl, aminoalkyl, alkylamino, alkoxy or alkoxyaryl; R 3 is alkyl, aryl, aminoalkyl, alkylamino, alkoxy or alkoxyaryl. Furthermore, R can also be alkyl, aryl, alkylaryl, arylalkyl, aminoalkyl, alkylamino, alkoxy, haloalkylaryl, alkylsilyl, alkylthio, alkylthioaryl, or substituent contaning CN, CO, COOH, COOCH 3 or heterocyclic moieties; and R 4 is perfluoroalkyl. The thiocarbonylthio compound can be used as a reversible chain transfer agent in a free radical polymerization to obtain a polymer with a controlled molecular weight and narrow polydispersity.

  一种硫代羰基硫化合物和利用该硫代羰基硫化合物进行自由基聚合的方法。该硫代羰基硫化合物由式(I)或(II)表示：其中Z可以独立地是全氟烷基、烷基、卤代烷基、芳基、烷基芳基、卤代烷基芳基、芳基烷基、氨基烷基、烷基氨基、烷氧基、烷氧基芳基、烷基磺酰基、烷基磺酰基芳基、二烷基膦基或二烷基磷硫酰基；R1和R2可以各自独立地是氢、烷基、芳基、烷基芳基、芳基烷基、氨基烷基、烷基氨基、烷氧基或烷氧基芳基；R3是烷基、芳基、氨基烷基、烷基氨基、烷氧基或烷氧基芳基。此外，R也可以是烷基、芳基、烷基芳基、芳基烷基、氨基烷基、烷基氨基、烷氧基、卤代烷基芳基、烷基硅基、烷基硫基、烷基硫基芳基，或含有CN、CO、COOH、COOCH3或杂环基团的取代基；R4是全氟烷基。该硫代羰基硫化合物可用作自由基聚合中可逆链转移剂，以获得具有受控分子量和窄聚分度的聚合物。