N-(7-methyl-1H-indol-3-ylmethyl)-acetamide | 1019645-57-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(7-methyl-1H-indol-3-ylmethyl)-acetamide
• 英文别名: Acetamide,n-[(7-methyl-1h-indol-3-yl)methyl]-；N-[(7-methyl-1H-indol-3-yl)methyl]acetamide
• CAS: 1019645-57-8
• 化学式: C₁₂H₁₄N₂O
• 分子量: 202.256
• InChiKey: UKELAXYBNZFHDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44.9
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-methyl-2-p-tolyl-cyclobutane-1,3-dione 、 苯甲醛 、 N-(7-methyl-1H-indol-3-ylmethyl)-acetamide 生成 N-{2-[(2-hydroxy-3-methyl-4-oxo-3-p-tolyl-cyclobut-1-enyl)-phenyl-methyl]-7-methyl-1H-indol-3-ylmethyl}-acetamide
  参考文献：
  名称：

  Vinylogous acid derivatives

  摘要：

  本发明涉及公式I的新型vinylogous酸衍生物：其中A和R1至R5如描述和权利要求中所定义，并且其生理上可接受的盐。这些化合物可用作chymase抑制剂。

  公开号：

  US07705034B2

文献信息

• [EN] SPIRO-LACTAM AND BIS-SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS SPIRO-LACTAMES ET BIS-SPIRO-LACTAMES DES RÉCEPTEURS NMDA ET LEURS UTILISATIONS
  申请人：APTINYX INC

  公开号：WO2018026792A1

  公开（公告）日：2018-02-08

  Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

  揭示了具有调节NMDA受体活性潜力的化合物。这些化合物可用于治疗
• [EN] CYCLOPENTADIENYL/ADAMANTYL PHOSPHINIMINE ZIRCONIUM AND HAFNIUM COMPLEXES<br/>[FR] COMPLEXES CYCLOPENTADIÉNYLE/ADAMANTYLE PHOSPHINIMINE ZIRCONIUM ET HAFNIUM
  申请人：NOVA CHEM INT SA

  公开号：WO2021214612A1

  公开（公告）日：2021-10-28

  Provided in this disclosure are zirconium and hafnium complexes that contain 1) a cyclopentadienyl ligand; 2) an adamantyl-phosphinimine ligand; and 3) at least one other ligand. The use of such a complex, in combination with an activator, as an olefin polymerization catalyst is demonstrated. The catalysts are effective for the copolymerization of ethylene with an alpha olefin (such as 1-butene, 1-hexene, or 1-octene).

  本披露提供了含有1）环戊二烯基配体；2）金刚烷基膦亚胺配体；和3）至少另一种配体的锆和铪配合物。演示了将这种复合物与活化剂结合作为烯烃聚合催化剂的用途。这些催化剂对乙烯与α-烯烃（如1-丁烯、1-己烯或1-辛烯）的共聚合是有效的。
• METHODS OF TREATING DISEASES AND DISORDERS RESULTING FROM BETA CORONAVIRUS INFECTION
  申请人：T3D Therapeutics, Inc.

  公开号：US20210369680A1

  公开（公告）日：2021-12-02

  This disclosure describes the use of indane acetic acid derivatives which are PPAR agonists, including PPAR delta, PPAR gamma, and dual PPAR delta and gamma agonists, and which penetrate the blood brain barrier to achieve effective brain to plasma drug levels at non-toxic doses, for the treatment of betacoronavirus diseases, such as COVID-19 and COVID-19 related co-morbid diseases, including Acute Respiratory Distress and CNS disorders, such as delirium and cognitive impairment.

  本公开说明了使用indane乙酸衍生物作为PPAR激动剂，包括PPAR delta，PPAR gamma和双重PPAR delta和gamma激动剂，这些激动剂穿过血脑屏障，在非毒性剂量下实现有效的脑血浆药物水平，用于治疗β冠状病毒疾病，如COVID-19和COVID-19相关的共病疾病，包括急性呼吸窘迫和中枢神经系统疾病，如谵妄和认知障碍。
• Thermosetting composition with photo-alignment property, alignment layer, substrate with alignment layer, retardation plate, and device
  申请人：DAI NIPPON PRINTING CO., LTD.

  公开号：US10017696B2

  公开（公告）日：2018-07-10

  A thermosetting composition with a photo-alignment property includes a copolymer containing a photo-alignment constitutional unit represented by the following formula (1) and a thermal cross-linking constitutional unit represented by the following formula (2). Here, in the formula (1), X represents a photo-alignment group, L1 represents a divalent linking group or a single bond, R1 represents a hydrogen atom or a monovalent organic group, and k represents 1 to 5; in the formula (2), Y represents a thermal cross-linking group, L2 represents a divalent linking group or a single bond, R2 represents a hydrogen atom or a monovalent organic group, and 1 represents 1 to 5.

  一种具有光配位特性的热固性组合物包括一种共聚物，该共聚物含有下式（1）表示的光配位结构单元和下式（2）表示的热交联结构单元。式（1）中，X 代表光配位基团，L1 代表二价连接基团或单键，R1 代表氢原子或一价有机基团，k 代表 1 至 5；式（2）中，Y 代表热交联基团，L2 代表二价连接基团或单键，R2 代表氢原子或一价有机基团，1 代表 1 至 5。
• Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof
  申请人：Aptinyx Inc.

  公开号：US11028095B2

  公开（公告）日：2021-06-08

  Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

  所公开的化合物具有调节 NMDA 受体活性的功效。此类化合物可用于治疗抑郁症及相关疾病。此外，还公开了口服制剂和其他药学上可接受的化合物给药形式，包括静脉注射制剂。