n-pentyl α-D-galactopyranoside | 913074-15-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: n-pentyl α-D-galactopyranoside
• 英文别名: (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-pentoxyoxane-3,4,5-triol
• CAS: 913074-15-4
• 化学式: C₁₁H₂₂O₆
• 分子量: 250.292
• InChiKey: RYIWDDCNJPSPRA-KJPMQGKISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  99.4
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  n-pentyl α-D-galactopyranoside 、 3-溴丙烯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以60%的产率得到
  参考文献：
  名称：

  Synthesis, CI-MS Analyses and Preliminary Biological Evaluation of a Novel Library of Hydrophobic Persulfide-Spacers α-Alkyl Glycosides

  摘要：

  We report the synthesis of novel polyether-based polyols derived from simple glycosides that bear sulfur spacers in the attempt to potentially provide new antibiotics. The CI-MS demonstrated the stepwise and successive fission of the sulfide-spacer groups; however, it does not distinguish between the alditols having different arrangement of O(CH2)(3)-S(CH2)(2)OH groups. The investigated compounds exhibited antimicrobial activities against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and antifungal activities against Candida albicans at a concentration of 1 mg / ml in DMF.

  DOI：

  10.2174/157017810790796372
• 作为产物：
  描述：

  口服葡萄糖 、 戊醇 在 iron(III) chloride 作用下， 以33%的产率得到n-pentyl α-D-galactopyranoside
  参考文献：
  名称：

  Synthesis, CI-MS Analyses and Preliminary Biological Evaluation of a Novel Library of Hydrophobic Persulfide-Spacers α-Alkyl Glycosides

  摘要：

  We report the synthesis of novel polyether-based polyols derived from simple glycosides that bear sulfur spacers in the attempt to potentially provide new antibiotics. The CI-MS demonstrated the stepwise and successive fission of the sulfide-spacer groups; however, it does not distinguish between the alditols having different arrangement of O(CH2)(3)-S(CH2)(2)OH groups. The investigated compounds exhibited antimicrobial activities against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and antifungal activities against Candida albicans at a concentration of 1 mg / ml in DMF.

  DOI：

  10.2174/157017810790796372

文献信息

• Novel SGLT inhibitors
  申请人：Nomura Sumihiro

  公开号：US20080027014A1

  公开（公告）日：2008-01-31

  Novel compounds of formula (A) or a pharmaceutically acceptable salt thereof: wherein symbols are as defined in claims, which are useful as SGLT inhibitors and for treatment of diabetes and related diseases.

  化合物的新颖结构式（A）或其药学上可接受的盐： 其中符号如权利要求中所定义，这些化合物可用作SGLT抑制剂，用于治疗糖尿病及相关疾病。
• POLYMER STABILIZER
  申请人：KIMURA Yoshikazu

  公开号：US20100179253A1

  公开（公告）日：2010-07-15

  A polymer stabilizer comprising the following alkoxy compound: the alkoxy compound: a compound obtained by alkoxylating at least one hydroxyl group contained in a compound of the following formula (1) containing one formyl group or carbonyl group and (n− 1 ) hydroxyl groups in the molecule with an alkyl group having 1 to 12 carbon atoms: C n H 2n O n (1) (wherein, n represents an integer of 3 or more).

  一种聚合物稳定剂，包含以下烷氧基化合物：所述烷氧基化合物是通过将含有以下通式（1）中的一个甲酰基或羰基以及分子中（n-1）个羟基的化合物中的至少一个羟基进行烷氧基化而得到的化合物，其中烷基团含有1至12个碳原子：CnH2nOn（1）（其中，n代表3或以上的整数）。
• THERMOPLASTIC POLYMER COMPOSITION AND PROCESSING STABILISER
  申请人：Kimura Yoshikazu

  公开号：US20130032756A1

  公开（公告）日：2013-02-07

  The present invention provides a thermoplastic polymer composition containing a particular phenol compound or organic phosphoric compound, compound (9) which is compound (9a) represented by C m H 2m O m wherein m is an integer of not less than 3 and not more than 10, and having one aldehyde group or ketone group and m−1 hydroxy groups with at least one hydroxy group having been replaced by an alkoxy group represented by —OR 26 wherein R 26 is a C 1-12 alkyl group, and a thermoplastic polymer, and a processing stabilizer containing a particular phenol compound or organic phosphoric compound, and compound (9). A combined use of a particular phenol compound or organic phosphoric compound and compound (9) can improve processing stability of a thermoplastic polymer composition.

  本发明提供了一种热塑性聚合物组合物，其中包含特定的酚化合物或有机磷化合物、化合物(9)，该化合物(9)表示为CmH2mOm，其中m是不小于3且不大于10的整数，具有一个醛基或酮基和m-1个羟基，其中至少一个羟基已被一个表示为—OR26的烷氧基所取代，其中R26是C1-12烷基，以及一种热塑性聚合物和一种加工稳定剂，该加工稳定剂包含特定的酚化合物或有机磷化合物和化合物(9)。特定的酚化合物或有机磷化合物和化合物(9)的联合使用可以提高热塑性聚合物组合物的加工稳定性。
• Polymer stabilizer
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2206740A2

  公开（公告）日：2010-07-14

  A polymer stabilizer comprising the following alkoxy compound: the alkoxy compound: a compound obtained by alkoxylating at least one hydroxyl group contained in a compound of the following formula (1) containing one formyl group or carbonyl group and (n-1) hydroxyl groups in the molecule with an alkyl group having 1 to 12 carbon atoms:          CnH2nOn     (1) (wherein n represents an integer of 3 or more).

  一种由下述烷氧基化合物组成的聚合物稳定剂： 烷氧基化合物：通过将分子中含有一个甲酰基或羰基和（n-1）个羟基的下式 （1）化合物中所含的至少一个羟基与具有 1 至 12 个碳原子的烷基进行烷氧基化而得 到的化合物： CnH2nOn (1) (其中 n 代表 3 个或更多的整数）。
• Cellulase assay
  申请人：Megazyme IP Limited

  公开号：EP2719758A1

  公开（公告）日：2014-04-16

  The invention involves the development of a substrate and assay procedure for the scientific measurement of cellulase in admixture with other enzymes active on cellulose or 1,4-β-D-gluco-oligosaccharides, or in various levels of purity of the cellulase. This substrate being characterised by the fact that it contains at least 2 glucose units linked β-1,4-, with the reducing end glucose unit linked β- or α- to a compound which exhibits an optically measurable change on cleavage of the bond between it and the adjacent D-glucosyl residue and the non-reducing terminal D-glucosyl unit is covalently linked to a blocking substituent which inhibits cleavage by exo-acting enzymes of the bond between the terminal and non-reducing end, penultimate D-glucose unit.

  本发明涉及开发一种底物和测定程序，用于科学测定纤维素酶与其他对纤维素或 1，4-β-D-葡聚寡糖有活性的酶混合的情况，或不同纯度的纤维素酶。这种底物的特点是，它至少含有 2 个连接在 β-1,4-上的葡萄糖单元，其中还原端的葡萄糖单元与一种化合物连接在 β- 或 α-上，这种化合物在裂解它与相邻 D-葡萄糖残基之间的键时显示出可测量的光学变化，而非还原端的 D-葡萄糖单元与一种阻断取代基共价连接，这种取代基抑制外作用酶裂解末端和非还原端、倒数第二个 D-葡萄糖单元之间的键。