methyl 6-(5-chloro-2-methoxyphenyl)-4-methyl-2-phenyl-5,6-dihydro-4H-1,3-oxazine-5-carboxylate | 889855-74-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: methyl 6-(5-chloro-2-methoxyphenyl)-4-methyl-2-phenyl-5,6-dihydro-4H-1,3-oxazine-5-carboxylate
• CAS: 889855-74-7
• 化学式: C₂₀H₂₀ClNO₄
• 分子量: 373.836
• InChiKey: AINYMCWGXUTAHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 6-(5-chloro-2-methoxyphenyl)-4-methyl-2-phenyl-5,6-dihydro-4H-1,3-oxazine-5-carboxylate 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 methyl (2E)-2-[1-(benzoylamino)ethyl]-3-(5-chloro-2-methoxyphenyl)-2-propenoate
  参考文献：
  名称：

  PROCESS FOR PRODUCING 1-CARBAMOYL-3,7-DIOXO-1,4-DIAZEPANE COMPOUNDS

  摘要：

  公开号：

  EP2025672B1
• 作为产物：
  描述：

  methyl 3-(benzoylamino)-2-[(5-chloro-2-methoxyphenyl)(hydroxy)methyl]butanoate 在 硫酸 、 三氟乙酸 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 1.0h， 生成 methyl 6-(5-chloro-2-methoxyphenyl)-4-methyl-2-phenyl-5,6-dihydro-4H-1,3-oxazine-5-carboxylate
  参考文献：
  名称：

  7-MEMBERED RING COMPOUND, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL USE THEREOF

  摘要：

  公开号：

  EP1820798B1

文献信息

• 7-MEMBERED RING COMPOUND AND METHOD OF PRODUCTION AND PHARMACEUTICAL APPLICATION THEREOF
  申请人：Muto Tsuyoshi

  公开号：US20090253683A1

  公开（公告）日：2009-10-08

  A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.

  本发明提供一种具有式(I)的7元杂环化合物或其盐或其溶剂合物，具有抑制chymase的作用，用于预防或治疗各种涉及chymase的疾病的方法，以及用于预防或治疗各种涉及chymase的疾病的药物组合物，包括具有式(I)的化合物或其药学上可接受的盐或其溶剂合物的药物组合物。
• 7-membered ring compound and method of production and pharmaceutical application thereof
  申请人：Muto Tsuyoshi

  公开号：US20090111796A1

  公开（公告）日：2009-04-30

  A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.

  提供了一种具有以下公式（I）或其盐或溶剂化物的七元杂环化合物，具有抑制chymase作用，可用于预防或治疗各种涉及chymase的疾病的方法，以及用于预防或治疗这些疾病的制药组合物，包括具有以下公式（I）或其药学上可接受的盐或溶剂化物的化合物。
• SEVEN-MEMBERED RING COMPOUND, PRODUCTION METHOD THEREOF AND PHARMACEUTICAL USE THEREOF
  申请人：Asubio Pharma Co., Ltd.

  公开号：EP2025672A1

  公开（公告）日：2009-02-18

  A 7-membered heterocyclic compound having the formula (I), or its salt, or a solvate thereof with a chymase inhibitory action and useful for the prevention or treatment of various diseases, in which chymase is involved: a method for producing the same, and a pharmaceutical composition useful for the prevention or treatment of diseases, in which chymase is involved, including the compound of having the formula (I), or its pharmaceutically acceptable salt, or a solvate thereof are provided.

  本发明提供了一种具有式 (I) 的 7 元杂环化合物，或其盐，或其溶液，具有糜蛋白酶抑制作用，可用于预防或治疗涉及糜蛋白酶的各种疾病：一种生产该化合物的方法，以及一种用于预防或治疗涉及糜蛋白酶的疾病的药物组合物，包括具有式 (I) 的化合物，或其药学上可接受的盐，或其溶液。
• Aminomethyl-substituted aromatic acids as intermediates for the preparation of chymase inhibiting 1,4-diazepan-2,5-dione compounds
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2463268A1

  公开（公告）日：2012-06-13

  A compound, or its salt or a solvate thereof, having the formula (Va): for producing a 7-membered heterocyclic compound, or its salt or a solvate thereof having formula (I): the compound of formula (I) having a chymase inhibitory action and useful for the prevention or treatment of various diseases in which chymase is involved and a method of producing a compound of formula (I) from a compound of formula (Va) are provided.

  具有式 (Va) 的化合物或其盐或溶液： 用于生产式（I）的 7 元杂环化合物或其盐或其溶液： 本发明提供了具有糜蛋白酶抑制作用并可用于预防或治疗涉及糜蛋白酶的各种疾病的式 (I) 化合物，以及由式 (Va) 化合物生产式 (I) 化合物的方法。
• 4-(Aminomethyl)benzoic acids as intermediates for the preparation of chymase inhibiting 1,4-diazepan-2,5-dione compounds
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2463268B1

  公开（公告）日：2013-08-28