2-(2-ethyl-4-methylimidazol-1-yl)ethylamine | 1036397-15-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(2-ethyl-4-methylimidazol-1-yl)ethylamine
• 英文别名: 2-(2-ethyl-4-methylimidazol-1-yl)ethanamine
• CAS: 1036397-15-5
• 化学式: C₈H₁₅N₃
• 分子量: 153.227
• InChiKey: RAGYBECFIRFLOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-ethyl-4-methylimidazol-1-yl)ethylamine 、 3-[4-(三氟甲基)苯基]丙醛 生成 3-ethyl-1-methyl-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine
  参考文献：
  名称：

  5,6,7,8-tetrahydro-imidazo[1,5-α]pyrazine derivatives

  摘要：

  本发明涉及一种式为(I)的5,6,7,8-四氢咪唑[1,5-a]吡嗪衍生物，其中X代表CH2或O；R1代表苯基，该基团独立地单取代、双取代或三取代，其中取代基独立地选自(C1-4)烷基，(C1-4)烷氧基，卤素，氰基，三氟甲氧基和三氟甲基的群；R2代表(C1-4)烷基，(C1-4)烷氧基，(C2-4)烯基，卤素，氰基，羟甲基，三氟甲基，C(O)NR5R6或环丙基；R3代表(C1-4)烷基，(C1-4)烷氧甲基或卤素；R4代表(C1-4)烷基；R5代表氢或(C1-4)烷基；R6代表氢或(C1-4)烷基。本发明还涉及该类化合物的药学上可接受的盐；以及将该类化合物用作药物，特别是促进睡眠的药物。

  公开号：

  US08188082B2

文献信息

• 5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES
  申请人：Aissaoui Hamed

  公开号：US20100093740A1

  公开（公告）日：2010-04-15

  The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I), wherein X represents CH 2 or O; R 1 represents a phenyl group, which group is independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, cyano, trifluoromethoxy and trifluoromethyl; R 2 represents (C 1-4 )alkyl, (C 1-4 )alkoxy, (C 2-4 )alkenyl, halogen, cyano, hydroxymethyl, trifluoromethyl, C(O)NR 5 R 6 or cyclopropyl; R 3 represents (C 1-4 )alkyl, (C 1-4 )alkoxy-methyl or halogen; R 4 represents (C 1-4 )alkyl; R 5 represents hydrogen or (C 1-4 )alkyl; and R 6 represents hydrogen or (C 1-4 )alkyl. The invention also relates to pharmaceutically acceptable salts of such compounds; and to the use of such compounds as medicaments; especially as orexin receptor antagonists.

  本发明涉及公式（I）的5,6,7,8-四氢咪唑[1,5-a]吡嗪衍生物，其中X代表CH2或O; R1代表苯基，该基团独立地单取代、双取代或三取代，其中取代基独立地选自由（C1-4）烷基，（C1-4）烷氧基，卤素，氰基，三氟甲氧基和三氟甲基的群组; R2代表（C1-4）烷基，（C1-4）烷氧基，（C2-4）烯基，卤素，氰基，羟甲基，三氟甲基，C（O）NR5R6或环丙基; R3代表（C1-4）烷基，（C1-4）烷氧甲基或卤素; R4代表（C1-4）烷基; R5代表氢或（C1-4）烷基; R6代表氢或（C1-4）烷基。本发明还涉及这种化合物的药学上可接受的盐;以及将这种化合物用作药物的用途;特别是作为促进睡眠激素受体拮抗剂。
• CURABLE COMPOSITION
  申请人：Showa Denko K.K.

  公开号：EP2383310A1

  公开（公告）日：2011-11-02

  It is an obj ect of the present invention to provide a curable composition which provides a cured product excellent in low warpage properties and long-term electrical insulation reliability and causes little bleeding during screen printing. The present invention is a curable composition comprising the following components (a) to (e) : a component (a) : polyurethane having a functional group capable of curing reaction and a carbonate bond, a component (b): γ-butyrolactone, a component (c) : diethylene glycol diethyl ether, a component (d) : inorganic fine particles and/or organic fine particles, and a component (e): a compound having two or more epoxy groups in one molecule.

  本发明的目的是提供一种固化组合物，其固化产品具有优异的低翘曲性能和长期电绝缘可靠性，并且在丝网印刷过程中几乎不会产生渗色。本发明是一种可固化组合物，包括以下组分（a）至（e）：组分（a）：具有可固化反应的官能团和碳酸键的聚氨酯；组分（b）：γ-丁内酯；组分（c）：二乙二醇二乙醚；组分（d）：无机微粒和/或有机微粒；以及组分（e）：在一个分子中具有两个或两个以上环氧基团的化合物。
• (POLY)CARBONATE POLYOL AND CARBOXYL GROUP-CONTAINING POLYURETHANE USING THE (POLY)CARBONATE POLYOL AS STARTING MATERIAL
  申请人：Showa Denko K.K.

  公开号：EP2390277A1

  公开（公告）日：2011-11-30

  An object of the invention is to provide carboxyl group-containing polyurethanes that have small curing warpage and can give cured products having excellent electrical insulating properties and flexibility, curable compositions that contain the carboxyl group-containing polyurethane and can give cured products having good electrical insulating properties, cured products obtained from the compositions, flexible circuit boards covered with the cured products, and processes for manufacturing flexible circuit boards. The carboxyl group-containing polyurethane is obtainable from materials including a (poly)carbonate polyol (a), a polyisocyanate (b) and a carboxyl group-containing polyol (c). The (poly) carbonate polyol includes an organic residue derived from a dimer diol and an organic residue derived from a polyol having a C10-20 alicyclic structure.

  本发明的目的是提供固化翘曲小并能得到具有优异电绝缘性能和柔韧性的固化产品的含羧基聚氨酯、含有含羧基聚氨酯并能得到具有优异电绝缘性能的固化产品的可固化组合物、由组合物得到的固化产品、覆盖有固化产品的柔性电路板以及制造柔性电路板的工艺。含羧基的聚氨酯可从包括（多）碳酸酯多元醇（a）、多异氰酸酯（b）和含羧基的多元醇（c）的材料中获得。(聚)碳酸酯多元醇包括衍生自二聚二元醇的有机残留物和衍生自具有 C10-20 脂环结构的多元醇的有机残留物。
• NOVEL POLYURETHANE, CURABLE COMPOSITION, OVERCOAT FILM, AND FLEXIBLE WIRING BOARD AND PRODUCTION METHOD THEREFOR
  申请人：Showa Denko K.K.

  公开号：EP3395848A1

  公开（公告）日：2018-10-31

  Provided are a polyurethane and a curable composition capable of obtaining an overcoat film for a flexible wiring board that is excellent in low-warpage properties, flexibility, long-term insulation reliability, and wiring disconnection preventing properties. The polyurethane has: a structural unit of formula (1) (in formula (1), an n-number of R1 each independently represents a 1,2-phenylene group or a 1,2-phenylene group having a substituent, an (n+1)-number of R2 each independently represents a hydrocarbon group having 3-9 carbon atoms, and n represents an integer from 1 to 50); a structural unit of formula (2) (in formula (2), R3 represents a divalent organic group having 6-14 carbon atoms); and a structural unit of formula (3) (in formula (3), R3 represents a divalent organic group having 6-14 carbon atoms, and R4 represents a methyl or ethyl group).

  本发明提供了一种聚氨酯和一种固化组合物，能够获得在低弯曲性、柔韧性、长期绝缘可靠性和防止配线断开方面性能优异的柔性配线板用覆膜。该聚氨酯具有式（1）的结构单元（在式（1）中，R1 的 n 数各自独立地代表 1，2-亚苯基或具有取代基的 1，2-亚苯基，R2 的（n+1）数各自独立地代表具有 3-9 个碳原子的烃基，n 代表 1 至 50 之间的整数）；式（2）的结构单元（式（2）中，R3 代表具有 6-14 个碳原子的二价有机基团）；以及式（3）的结构单元（式（3）中，R3 代表具有 6-14 个碳原子的二价有机基团，R4 代表甲基或乙基）。
• Curable composition, cured object, overcoat film, coated flexible wiring board, and process for producing same
  申请人：NIPPON POLYTECH CORP.

  公开号：US10889729B2

  公开（公告）日：2021-01-12

  A curable composition for forming an overcoat film for flexible wiring boards, the curable composition being effective in improving adhesion to substrates, low warpage, flexibility, the property of inhibiting wire breakage, and long-term reliability. The curable composition according to the present invention comprises a polyurethane (component a) having carboxyl groups and an aromatic-ring concentration of 0.1-6.5 mmol/g and containing an organic residue derived from a polyisocyanate, a solvent (component b), and a compound (component c) having two or more epoxy groups in the molecule.

  一种可固化组合物，用于形成柔性布线板的覆膜，该可固化组合物能有效改善与基材的粘附性、低翘曲性、柔韧性、抑制断线特性和长期可靠性。根据本发明的可固化组合物包括具有羧基和芳香环浓度为 0.1-6.5 mmol/g 的聚氨酯 （a 组份），其中含有从多异氰酸酯衍生的有机残留物、溶剂（b 组份）和分子中含有两个或更多环氧基团的化合物 （c 组份）。