[1,2,3]Thiadiazole-4-carboxylic acid (5-amino-pyridin-2-yl)-amide | 742097-77-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [1,2,3]Thiadiazole-4-carboxylic acid (5-amino-pyridin-2-yl)-amide
• 英文别名: N-(5-aminopyridin-2-yl)thiadiazole-4-carboxamide
• CAS: 742097-77-4
• 化学式: C₈H₇N₅OS
• 分子量: 221.242
• InChiKey: KJYILJSQXABTKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  122
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  [1,2,3]Thiadiazole-4-carboxylic acid (5-amino-pyridin-2-yl)-amide 以 乙腈 为溶剂， 生成 N-{5-[({[3,5-bis(trifluoromethyl)benzyl]amino}carbothioyl)amino]-2-pyridinyl}-1,2,3-thiadiazole-4-carboxamide
  参考文献：
  名称：

  Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N′-arylthiourea inhibitors of CMV

  摘要：

  A series of highly potent thiourea inhibitors of cytomegalovirus (CMV) with improved stability properties was prepared and evaluated. Compound 29 inhibited the virus in cultured HFF cells with IC50 of 0.2 nM. (C) 2004 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2004.04.093
• 作为产物：
  描述：

  N-(5-硝基-2-吡啶基)-1,2,3-噻二唑-4-甲酰胺 在 铁粉 、 氯化铵 作用下， 生成 [1,2,3]Thiadiazole-4-carboxylic acid (5-amino-pyridin-2-yl)-amide
  参考文献：
  名称：

  Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N′-arylthiourea inhibitors of CMV

  摘要：

  A series of highly potent thiourea inhibitors of cytomegalovirus (CMV) with improved stability properties was prepared and evaluated. Compound 29 inhibited the virus in cultured HFF cells with IC50 of 0.2 nM. (C) 2004 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2004.04.093

文献信息

• Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl-N′-arylthiourea inhibitors of CMV
  作者：Jonathan D. Bloom、Russell G. Dushin、Kevin J. Curran、Fran Donahue、Emily B. Norton、Eugene Terefenko、Thomas R. Jones、Adma A. Ross、Boris Feld、Stanley A. Lang、Martin J. DiGrandi

  DOI：10.1016/j.bmcl.2004.04.093

  日期：2004.7

  A series of highly potent thiourea inhibitors of cytomegalovirus (CMV) with improved stability properties was prepared and evaluated. Compound 29 inhibited the virus in cultured HFF cells with IC50 of 0.2 nM. (C) 2004 Published by Elsevier Ltd.