class-I huvastatin carboxylic acid | 95463-68-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: class-I huvastatin carboxylic acid
• 英文别名: (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-6-hydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid
• CAS: 95463-68-6
• 化学式: C₂₄H₃₈O₇
• 分子量: 438.562
• InChiKey: BKJBFYASJVBBPO-OHVHAHAYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  class-I huvastatin carboxylic acid 、 2,2-二甲氧基丙烷 在 4-methylbenzenesulfonic acid sodium carbonate 作用下， 反应 1.0h， 生成 2,2-dimethylbutyric acid 3-hydroxy-8-[2-(6-methoxycarbonyl-2,2-dimethyl[1,3]-dioxanyl)-ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl ester
  参考文献：
  名称：

  EP1693360

  摘要：

  公开号：

文献信息

• Huvastatin and its preparation and formulation comprising the huvastatin
  申请人：Ye Hongping

  公开号：US20070185193A1

  公开（公告）日：2007-08-09

  The invention relates to statin compounds, and it discloses novel small molecule compounds, i.e., huvastatins, which are classified into I, II, and III. The invention also provides the preparation methods thereof and the formulations comprising the huvastatin as active ingredient. The present compounds can be used at lower dosage compared to the existing statin compounds, and also can help to control the desired blood lipid levels of the patients with hyperlipidemia. Huvastatin of the invention exhibits suitable hydrophilicity, strong potency and therapeutical effect for reducing lipid levels, and lower dosage.