3-(Hydroxymethyl)-4-methoxybenzenesulfonamide | 900165-91-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(Hydroxymethyl)-4-methoxybenzenesulfonamide
• 英文别名: 4-methoxy-3-(hydroxymethyl)phenylsulfonamide；3-(Hydroxymethyl)-4-methoxybenzene-1-sulfonamide
• CAS: 900165-91-5
• 化学式: C₈H₁₁NO₄S
• 分子量: 217.246
• InChiKey: VIPQBIKWDATFSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  98
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(Hydroxymethyl)-4-methoxybenzenesulfonamide 在 叠氮磷酸二苯酯 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 为溶剂， 生成 3-(azidomethyl)-4-methoxybenzenesulfonamide
  参考文献：
  名称：

  Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants

  摘要：

  本发明提供了式(I)或(IV)的新型苯基甘氨酰衍生物：或其立体异构体、互变异构体、药学上可接受的盐、溶剂合物或前药，其中变量W、W1、Y、Z、R7、R8、R9和R11如本文所定义。这些化合物是选择性因子VIIa的抑制剂，可用作药物。

  公开号：

  US20070003539A1
• 作为产物：
  描述：

  2-甲氧基-5-氨磺酰基苯甲酸乙酯 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 3-(Hydroxymethyl)-4-methoxybenzenesulfonamide
  参考文献：
  名称：

  Synthesis and inhibitory activity on carbonic anhydrase of some new sulpiride analogs studied by means of a new method

  摘要：

  The pharmacological activity of several new sulpiride analogues was studied by means of a new approach, based on a potentiometric technique with a pCO2 sensor, capable of detecting carbonic anhydrase inhibition at equilibrium conditions. This procedure gives results stated as percent of inhibition of enzymatic activity (IP, inhibitory power). To prove the reliability of the proposed approach and to study structure-activity relationships, several new molecules were synthesized and tested in comparison with the two sulpiride enantiomers. A possible inhibition mechanism is discussed in terms of experimental evidence obtained from the interactions between the molecular structures of the new synthesized compounds and carbonic anhydrase.

  DOI：

  10.1021/jm00160a003

文献信息

• SUBSTITUTED N-AMINOMETHYLENE SULFONAMIDES, PRODUCTION AND USE THEREOF AS MEDICAMENTS
  申请人：SCHOENAFINGER Karl

  公开号：US20080069851A1

  公开（公告）日：2008-03-20

  Disclosed are compounds of the general formula (I), with the definitions of the substituents R 1 to R 5 , A and X being detailed in the text, and to their physiologically tolerated salts, to processes for preparing these compounds and to the use thereof as inhibitors of hormone-sensitive lipase (HSL).

  本发明揭示了一般式（I）的化合物，其中定义了取代基R1到R5，A和X的详细信息，以及其生理耐受盐的制备过程，以及它们作为激素敏感性脂肪酶（HSL）抑制剂的用途。
• Substituted N-aminomethylene sulfonamides, production and use thereof as medicaments
  申请人：Sanofi-Aventis

  公开号：US07781613B2

  公开（公告）日：2010-08-24

  Disclosed are compounds of the general formula (I), with the definitions of the substituents R1 to R5, A and X being detailed in the text, and to their physiologically tolerated salts, to processes for preparing these compounds and to the use thereof as inhibitors of hormone-sensitive lipase (HSL).

  本发明涉及一般式（I）的化合物，其中取代基R1至R5，A和X的定义详见文本，并且涉及其生理上耐受的盐，制备这些化合物的过程以及将其用作激素敏感性脂肪酶（HSL）抑制剂的用途。
• WO2006/74957
  申请人：——

  公开号：——

  公开（公告）日：——
• SUBSTITUIERTE N-AMINOMETHYLENSULFONAMIDE, IHRE HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL
  申请人：SANOFI

  公开号：EP1841731B1

  公开（公告）日：2012-08-22
• PHENYLGLYCINAMIDE AND PYRIDYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS
  申请人：Bristol-Myers Squibb Company

  公开号：EP1910298A2

  公开（公告）日：2008-04-16