[EN] POLYMYXIN ANALOGS USEFUL AS ANTIBIOTIC POTENTIATORS<br/>[FR] ANALOGUES DE LA POLYMYXINE UTILES EN TANT QUE POTENTIALISATEURS D'ANTIBIOTIQUE
申请人:SPERO OPCO
公开号:WO2017189866A1
公开(公告)日:2017-11-02
The disclosure provides compounds of the formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt of either of the foregoing. The variables A, R1, and R2 are defined in the disclosure. The disclosure further includes pharmaceutical compositions comprising a compound of formula I together with at least one pharmaceutically acceptable carrier. The disclosure also includes a method of sensitizing bacteria to an antibacterial agent, comprising administering to a patient infected with the bacteria, simultaneously or sequentially, a therapeutically effective amount of the antibacterial agent and a compound of formula (I).
[EN] THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE<br/>[FR] COMPOSÉS THÉRAPEUTIQUEMENT ACTIFS ET LEURS PROCÉDÉS D'UTILISATION
申请人:AGIOS PHARMACEUTICALS INC
公开号:WO2013107291A1
公开(公告)日:2013-07-25
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.
[EN] THERAPEUTICALLY ACTIVE COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS THÉRAPEUTIQUEMENT ACTIFS ET UTILISATION DE CEUX-CI
申请人:AGIOS PHARMACEUTICALS INC
公开号:WO2015010626A1
公开(公告)日:2015-01-29
Provided are therapeutically active compounds and the use in manufacture of medicaments for treating a cancer characterized by the presence of a mutant allele of IDH1.
THERAPEUTICALLY ACTIVE COMPOSITIONS AND THEIR METHODS OF USE
申请人:Agios Pharmaceuticals, Inc.
公开号:US20130190249A1
公开(公告)日:2013-07-25
Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.