3-[4-(3-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl]aniline | 945865-20-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[4-(3-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl]aniline
• 英文别名: 3-[4-(3-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethylpyrazol-3-yl]aniline
• CAS: 945865-20-3
• 化学式: C₁₈H₁₆ClN₅
• 分子量: 337.812
• InChiKey: CXRYWDSGWGITOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  72.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-[4-(3-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl]aniline 、 异氰酸苯酯 在 吡啶 作用下， 反应 1.0h， 生成 N-{3-[4-(3-Chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl]phenyl}-N'-phenylurea
  参考文献：
  名称：

  Pyrrolo [2,3,B] Pyridine Derivatives Useful As RAF Kinase Inhibitors

  摘要：

  本发明提供吡咯吡啶化合物，含有这些化合物的组合物，以及制备这些化合物的过程和它们作为药物的用途。

  公开号：

  US20090018156A1

文献信息

• YopM as delivery vehicle for cargo molecules and as biological therapeutic for immunomodulation of inflammatory reactions
  申请人：Universitätsklinikum Münster

  公开号：EP2664339A2

  公开（公告）日：2013-11-20

  The present invention relates to the use of Yersinia outer protein M (YopM), a YopM fragment, or a YopM variant, which is capable of autopenetrating the cell membrane and of integrating into the cell cytosol without the requirement of additional factors for delivering a cargo molecule across the membrane to the cytosol of a cell. The present invention also relates to a pharmaceutical composition comprising YopM, a YopM fragment, or a YopM variant being capable of autopenetrating the cell membrane and of integrating into the cell cytosol without the requirement of additional factors for the regulation of inflammatory reactions of the immune system and the treatment of diseases caused by autoimmunity of the host.; The present invention further relates to a YopM fragment or variant, which is capable of autopenetrating the cell membrane and of integrating into the cell cytosol without the requirements of additional factors as well as such proteins or YopM linked to a cargo molecule.

  本发明涉及耶尔森菌外蛋白M（YopM）、YopM片段或YopM变体的用途，它们能够自动穿透细胞膜并整合到细胞胞浆中，而不需要额外的因子将货物分子穿过细胞膜输送到细胞胞浆中。本发明还涉及一种药物组合物，该组合物包含 YopM、YopM 片段或 YopM 变体，它们能够自动穿透细胞膜并整合到细胞胞浆中，而不需要额外的因子，用于调节免疫系统的炎症反应和治疗宿主自身免疫引起的疾病。本发明进一步涉及一种YopM片段或变体，它能够自动穿透细胞膜并整合到细胞胞质中，而不需要额外的因子以及与载货分子相连的此类蛋白质或YopM。
• CELL-PENETRATING BACTERIAL E3-UBIQITIN-LIGASES FOR USE IN IMMUNOTHERAPY
  申请人：Westfälische Wilhelms-Universität Münster

  公开号：EP3046931B1

  公开（公告）日：2021-05-12
• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSÉS CHIMIQUES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2007090141A2

  公开（公告）日：2007-08-09

  [EN] The present invention provides ethyl pyrazole compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.
  [FR] La présente invention concerne des composés de pyrazole d'éthyle, les compositions contenant ces composés, leurs procédés de préparation et leur utilisation comme agents pharmaceutiques.
• [EN] YOPM AS DELIVERY VEHICLE FOR CARGO MOLECULES AND AS BIOLOGICAL THERAPEUTIC FOR IMMUNOMODULATION OF INFLAMMATORY REACTIONS<br/>[FR] PROTÉINE YOPM UTILISÉE COMME VÉHICULE POUR LES MOLÉCULES CARGO ET COMME AGENT THÉRAPEUTIQUE BIOLOGIQUE POUR L'IMMUNOMODULATION DE RÉACTIONS INFLAMMATOIRES
  申请人：UNIVERSITAETSKLINIKUM MUENSTER

  公开号：WO2009115531A2

  公开（公告）日：2009-09-24

  The present invention relates to the use of Yersinia outer protein M (YopM), a YopM fragment, or a YopM variant, which is capable of autopenetrating the cell membrane and of integrating into the cell cytosol without the requirement of additional factors for delivering a cargo molecule across the membrane to the cytosol of a cell. The present invention also relates to a pharmaceutical composition comprising YopM, a YopM fragment, or a YopM variant being capable of autopenetrating the cell membrane and of integrating into the cell cytosol without the requirement of additional factors for the regulation of inflammatory reactions of the immune system and the treatment of diseases caused by autoimmunity of the host. The present invention further relates to a YopM fragment or variant, which is capable of autopenetrating the cell membrane and of integrating into the cell cytosol without the requirements of additional factors as well as such proteins or YopM linked to a cargo molecule.
• [EN] CELL-PENETRATING BACTERIAL E3-UBIQITIN-LIGASES FOR USE IN IMMUNOTHERAPY<br/>[FR] UBIQUITINE LIGASES E3 BACTÉRIENNES PÉNÉTRANT DANS LES CELLULES DESTINÉES À ÊTRE UTILISÉES EN IMMUNOTHÉRAPIE
  申请人：UNIV MUENSTER WILHELMS

  公开号：WO2015040215A1

  公开（公告）日：2015-03-26

  The present invention relates to cell-penetrating effector proteins of type III secretion system (T3SS)-containing bacteria of the genus Salmonella or Shigella and variants, fragments and immunmodulatory domains thereof, for use in immunotherapy. The present invention further relates to cell-penetrating effector proteins of type III secretion system (T3SS)-containing bacteria of the genus Salmonella or Shigella and variants, fragments and immunmodulatory domains thereof, for delivering cargo molecules into eukaryotic cells.