3-Ethyl-2-phenyl-1-prop-2-enylpyrano[3,2-e]indol-7-one | 1350890-50-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-Ethyl-2-phenyl-1-prop-2-enylpyrano[3,2-e]indol-7-one
• 英文别名: 3-ethyl-2-phenyl-1-prop-2-enylpyrano[3,2-e]indol-7-one
• CAS: 1350890-50-4
• 化学式: C₂₂H₁₉NO₂
• 分子量: 329.398
• InChiKey: BJFCDAGJYKZWPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  31.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-(Ethylamino)-5-(2-phenylethynyl)chromen-2-one 在 gold(III) chloride 、 potassium carbonate 、 sodium iodide 作用下， 以 甲苯 、 丁酮 为溶剂， 反应 20.75h， 生成 3-Ethyl-2-phenyl-1-prop-2-enylpyrano[3,2-e]indol-7-one
  参考文献：
  名称：

  Gold-catalyzed heteroannulation and allyl migration: synthesis of highly functionalized indole derivatives

  摘要：

  Highly substituted indole derivatives have been prepared in good to excellent yields by a novel gold-catalyzed cyclization accompanied by [3,3]-migration of the allyl strategy. We have been able to introduce an allyl group at the Cl position of pyrano[3,2-e]indol-6(7H)-one and pyrrolo[3,2-f]quinolin-7(6H)-one moieties that provide a scope for further transformation. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.09.108

文献信息

• Gold-catalyzed heteroannulation and allyl migration: synthesis of highly functionalized indole derivatives
  作者：K.C. Majumdar、Somjit Hazra、B. Roy

  DOI：10.1016/j.tetlet.2011.09.108

  日期：2011.12

  Highly substituted indole derivatives have been prepared in good to excellent yields by a novel gold-catalyzed cyclization accompanied by [3,3]-migration of the allyl strategy. We have been able to introduce an allyl group at the Cl position of pyrano[3,2-e]indol-6(7H)-one and pyrrolo[3,2-f]quinolin-7(6H)-one moieties that provide a scope for further transformation. (C) 2011 Elsevier Ltd. All rights reserved.