5-azido-4-methylpentanoic acid | 499101-21-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-azido-4-methylpentanoic acid
• CAS: 499101-21-2
• 化学式: C₆H₁₁N₃O₂
• 分子量: 157.172
• InChiKey: JMYHTLFLAJWRTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  51.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-azido-4-methylpentanoic acid 在 叠氮磷酸二苯酯 、 三乙胺 作用下， 以 正戊烷 为溶剂， 反应 15.5h， 以410 mg的产率得到1-Azido-4-isocyanato-2-methyl-butane
  参考文献：
  名称：

  Effect of Conformational Preorganization of a Three-Armed Host on Anion Binding and Selectivity

  摘要：

  A set of three-armed urea-containing anion receptors was prepared. The receptors all have the same binding topology but differ in the level of conformational preorganisation with respect to the arrangement of the side-arms relative to the platform and within the side arms themselves. This is mirrored in a specific increase (x 2.5) in the binding constant for chloride and in a 12-fold increase in the chloride nitrate-selectivity.

  DOI：

  10.1002/1521-3765(20021104)8:21<4946::aid-chem4946>3.0.co;2-v
• 作为产物：
  描述：

  diethyl 2-(3-chloro-2-methylpropyl)malonate 在 氢氧化钾 、 sodium azide 作用下， 以 乙醇 、 邻二甲苯 、 N,N-二甲基甲酰胺 为溶剂， 反应 115.5h， 生成 5-azido-4-methylpentanoic acid
  参考文献：
  名称：

  Effect of Conformational Preorganization of a Three-Armed Host on Anion Binding and Selectivity

  摘要：

  A set of three-armed urea-containing anion receptors was prepared. The receptors all have the same binding topology but differ in the level of conformational preorganisation with respect to the arrangement of the side-arms relative to the platform and within the side arms themselves. This is mirrored in a specific increase (x 2.5) in the binding constant for chloride and in a 12-fold increase in the chloride nitrate-selectivity.

  DOI：

  10.1002/1521-3765(20021104)8:21<4946::aid-chem4946>3.0.co;2-v

文献信息

• [EN] AZIDO ALKANOIC ACIDS AND DERIVATIVES THEREOF IN FEED FOR REDUCING METHANE FORMATION EMANATING FROM THE DIGESTIVE ACTIVITIES OF RUMINANTS<br/>[FR] ACIDES AZIDOALCANOÏQUES ET LEURS DÉRIVÉS DANS L'ALIMENTATION POUR RÉDUIRE UNE ÉMANATION DE FORMATION DE MÉTHANE À PARTIR DES ACTIVITÉS DIGESTIVES DE RUMINANTS
  申请人：DSM IP ASSETS BV

  公开号：WO2011045418A1

  公开（公告）日：2011-04-21

  The present invention relates to a method for reducing the production of methane emanating from the digestive activities of a ruminant by using as active compound at least one azido alkanoic acid and/or derivative thereof, which is administrated to the animal together with the feed. The invention also relates to the use of these ingredients in feed and feed additives such as premix, concentrates and total mixedration (TMR) or in the form of a bolus.