dodecyl anthranylate | 95367-89-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dodecyl anthranylate
• 英文别名: lauryl anthranilate；2-Amino-benzoesaeure-dodecylester；Dodecyl o-aminobenzoate；dodecyl 2-aminobenzoate
• CAS: 95367-89-8
• 化学式: C₁₉H₃₁NO₂
• 分子量: 305.461
• InChiKey: DFLRTTRPSHIDGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  22
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  dodecyl anthranylate 在 吡啶 、 4-二甲氨基吡啶 、 sodium azide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成 Dodecyl 2-[[4-azido-6-[(2-dodecoxycarbonylphenyl)carbamoyl]pyridine-2-carbonyl]amino]benzoate
  参考文献：
  名称：

  Synthesis and Structure of Intramolecularly Hydrogen Bonded Dendrons

  摘要：

  [GRAPHICS]A convenient synthesis of monodendrons whose conformation is restricted through the intervention of intramolecular hydrogen bonding and repulsive electrostatic interactions is described. X-ray crystal structure analysis of the second generation dendron shows the presence of a propeller-type secondary structure and indicates that the dendrons have assembled into a symmetrically interdigitated dimer in the solid state. H-1 NMR and IR spectral data are in agreement with the presence of intramolecular hydrogen bonding between the amides and the pyridine N throughout the dendron structure in solution.

  DOI：

  10.1021/ol990250o
• 作为产物：
  描述：

  十二烷醇 、 邻氨基苯甲酸甲酯 生成 dodecyl anthranylate
  参考文献：
  名称：

  Synthesis and Structure of Intramolecularly Hydrogen Bonded Dendrons

  摘要：

  [GRAPHICS]A convenient synthesis of monodendrons whose conformation is restricted through the intervention of intramolecular hydrogen bonding and repulsive electrostatic interactions is described. X-ray crystal structure analysis of the second generation dendron shows the presence of a propeller-type secondary structure and indicates that the dendrons have assembled into a symmetrically interdigitated dimer in the solid state. H-1 NMR and IR spectral data are in agreement with the presence of intramolecular hydrogen bonding between the amides and the pyridine N throughout the dendron structure in solution.

  DOI：

  10.1021/ol990250o

文献信息

• Silver halide color photographic material
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US05187055A1

  公开（公告）日：1993-02-16

  A silver halide color photographic material having at least one silver halide emulsion layer on a support, said photographic material containing at least one coupler represented by the following general formula (I) in a constituent layer, ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, each represents an alkyl, alkoxy, alkylthio, alkylsulfonyl, alkoxycarbonyl, alkoxysulfonyl, aryl, aryloxy, arylthio, arylsulfonyl and aryloxycarbonyl group; R.sub.3 and R.sub.4, which may be the same or different, each represents a group by which benzene can be substituted; Z represents nonmetal atoms necessary to form a 5- to 7-membered single or condensed hetero ring together with the nitrogen atom; and m and n each represents an integer of from 0 to 4, and when they are each a plural number, a plural R.sub.3 or a plural R.sub.4 may be the same or different.

  一种银卤化物彩色摄影材料，其在支撑物上具有至少一层银卤化物乳剂层，所述摄影材料在构成层中含有至少一种由以下一般式(I)表示的偶联剂：##STR1## 其中，R.sub.1和R.sub.2（可以相同或不同）分别表示烷基、烷氧基、烷硫基、烷基磺酰基、烷氧羰基、烷氧基磺酰基、芳基、芳氧基、芳硫基、芳基磺酰基和芳氧羰基基团；R.sub.3和R.sub.4（可以相同或不同）分别表示苯可以被取代的基团；Z表示必要的非金属原子，以与氮原子一起形成5至7个成员的单环或缩合杂环；m和n分别表示0至4的整数，当它们都是复数时，复数R.sub.3或复数R.sub.4可以相同或不同。
• A percutaneous absorption promoter, a tape plaster and a method of promoting percutaneous absorption
  申请人：LINTEC Corporation

  公开号：EP0552405A1

  公开（公告）日：1993-07-28

  A percutaneous absorption promoter comprises a derivative of amino acid in which the amino group has or does not have an acyl substituent or a hydrocarbon substituent, the carboxylic group has a hydrocarbon substituent and the part between the amino group and the carboxylic group has a specified structure. A tape plaster comprises the percutaneous absorption promoter described above. The method utilizes the the percutaneous absorption promoter described above. The percutaneous promoter of the invention has excellent ability of promoting the percutaneous absorption of pharmacologically active substances and excellent safety simultaneously, capable of delivering the desired pharmacologically active substances rapidly to the location of treatment or to all parts of the body through the circulating system and effective for curing various kinds of disease. The tape plaster comprising it and the method of promoting percutaneous absorption by utilizing it have the same advantages.

  一种经皮吸收促进剂包括一种氨基酸衍生物，其中的氨基具有或不具有酰基取代基 或烃基取代基，羧基具有烃基取代基，氨基和羧基之间的部分具有特定结构。胶带膏药包含上述经皮吸收促进剂。该方法利用了上述经皮吸收促进剂。 本发明的经皮吸收促进剂具有良好的促进药理活性物质经皮吸收的能力，同时具有极佳的安全性，能够将所需的药理活性物质通过循环系统快速输送到治疗部位或身体各部位，有效治疗各种疾病。由它组成的胶带膏药和利用它促进经皮吸收的方法具有相同的优点。
• A percutaneous absorption, a tape plaster and a method of promoting percutaneous absorption
  申请人：LINTEC Corporation

  公开号：EP0815871A1

  公开（公告）日：1998-01-07

  A percutaneous absorption promoter comprises a derivative of amino acid in which the amino group has or does not have an acyl substituent or a hydrocarbon substituent, the carboxylic group has a hydrocarbon substituent and the part between the amino group and the carboxylic group has a specified structure. A tape plaster comprises the percutaneous absorption promoter described above. The method utilizes the the percutaneous absorption promoter described above. The percutaneous promoter of the invention has excellent ability of promoting the percutaneous absorption of pharmacologically active substances and excellent safety simultaneously, capable of delivering the desired pharmacologically active substances rapidly to the location of treatment or to all parts of the body through the circulating system and effective for curing various kinds of disease. The tape plaster comprising it and the method of promoting percutaneous absorption by utilizing it have the same advantages.

  一种经皮吸收促进剂包括一种氨基酸衍生物，其中的氨基具有或不具有酰基取代基 或烃基取代基，羧基具有烃基取代基，氨基和羧基之间的部分具有特定结构。胶带膏药包含上述经皮吸收促进剂。该方法利用了上述经皮吸收促进剂。 本发明的经皮吸收促进剂具有良好的促进药理活性物质经皮吸收的能力，同时具有极佳的安全性，能够将所需的药理活性物质通过循环系统快速输送到治疗部位或身体各部位，有效治疗各种疾病。由它组成的胶带膏药和利用它促进经皮吸收的方法具有相同的优点。
• Selection of alcohols through Plackett-Burman design in lipase-catalyzed synthesis of anthranilic acid esters
  作者：C. V. Suresh Babu、S. Divakar

  DOI：10.1007/s11746-001-0218-y

  日期：2001.1

  AbstractLipase‐catalyzed synthesis of esters of anthranilic acid was attempted by employing alcohols of carbon chainlength C1–C18 using Plackett‐Burman experimental design. Of the alcohols employed, methanol, decanol, cetyl alcohol, and stearyl alcohols showed 99.9% significance. Esterification of anthranilic acid with methanol gave the highest yield at 45.6%. This study allows the selection of better alcohols for esterification of anthranilic acid.
• Tape plaster comprising anthranilic acid derivatives as percutaneous absorption promotors
  申请人：LINTEC Corporation

  公开号：EP0815871B1

  公开（公告）日：2002-07-17