(2E)-1-(2-naphthyl)-3-(2-fluorophenyl)-2-propen-1-one | 1002606-24-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (2E)-1-(2-naphthyl)-3-(2-fluorophenyl)-2-propen-1-one
• 英文别名: (E)-3-(2-fluorophenyl)-1-(2-naphthyl)prop-2-en-1-one；(E)-3-(2-fluorophenyl)-1-naphthalen-2-ylprop-2-en-1-one
• CAS: 1002606-24-7
• 化学式: C₁₉H₁₃FO
• 分子量: 276.31
• InChiKey: VIKKWGBRCIPPBX-VAWYXSNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氟苯甲醛 、 2-萘乙酮 在 potassium hydroxide 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 (2E)-1-(2-naphthyl)-3-(2-fluorophenyl)-2-propen-1-one
  参考文献：
  名称：

  Naphthylchalcones induce apoptosis and caspase activation in a leukemia cell line: The relationship between mitochondrial damage, oxidative stress, and cell death

  摘要：

  In this study, we investigated the effects of 24 chalcone derivatives from 2-naphthylacetophenone toward a lymphoblastic leukemia cell line (L1210). Three compounds, called R7, R13, and R15, presented concentration- and time-dependent cytotoxicity and induced cellular death by apoptosis via mitochondrial injury and oxidative stress. The effects of these compounds appear to occur through different mechanisms because R13 and R7 induced a greater disturbance of mitochondrial potential, and all compounds induced disturbances of cellular ATP content and increased caspase-3 activity before cellular death. These compounds also interfered with antioxidant enzymes activities and GSH content through different mechanisms. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.09.025