2-Amino-2-[(Z)-hydroxyimino]-N-(4-sulfamoyl-phenyl)-acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Amino-2-[(Z)-hydroxyimino]-N-(4-sulfamoyl-phenyl)-acetamide
• 英文别名: (2Z)-2-amino-2-hydroxyimino-N-(4-sulfamoylphenyl)acetamide
• 化学式: C₈H₁₀N₄O₄S
• 分子量: 258.258
• InChiKey: ODFQAPHPLUSKJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  156
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-Amino-2-[(Z)-hydroxyimino]-N-(4-sulfamoyl-phenyl)-acetamide 在 sodium carbonate 作用下， 以 甲醇 为溶剂， 反应 26.5h， 生成 N-(4-aminosulfonylphenyl)-5-morpholino-1,2,4-oxadiazolyl-3-carboxamide
  参考文献：
  名称：

  摘要：

  A convenient method for the synthesis of 3-carbamoyl-1,2,4-oxadiazoles from carbamoyl-amidoximes and chlorides or anhydrides of haloacetic acids was developed. The reactions of 3-carbamoyl-5-trichloromethyl-1,2,4-oxadiazoles with amines and N,N-dimethylhydrazine were studied.

  DOI：

  10.1023/a:1021348401329
• 作为产物：
  描述：

  2-氯-n-(4-磺酰基-苯基)-乙酰胺 在 吗啉 、 吡啶 、 1,2,3,4,5,6,7,8-八硫杂环辛烷 、 盐酸羟胺 作用下， 生成 2-Amino-2-[(Z)-hydroxyimino]-N-(4-sulfamoyl-phenyl)-acetamide
  参考文献：
  名称：

  Synthesis of carbamoylamidoximes

  摘要：

  A convenient procedure was developed for the synthesis of carbamoylamidoximes by the reaction of N(S)-substituted monothiooxamides with hydroxylamine hydrochloride in pyridine.

  DOI：

  10.1007/bf02494503

文献信息

• Synthesis of carbamoylamidoximes
  作者：V. N. Yarovenko、S. A. Kosarev、I. V. Zavarzin、M. M. Krayushkin

  DOI：10.1007/bf02494503

  日期：1998.10

  A convenient procedure was developed for the synthesis of carbamoylamidoximes by the reaction of N(S)-substituted monothiooxamides with hydroxylamine hydrochloride in pyridine.
• ——
  作者：V. N. Yarovenko、S. A. Kosarev、I. V. Zavarzin、M. M. Krayushkin

  DOI：10.1023/a:1021348401329

  日期：——

  A convenient method for the synthesis of 3-carbamoyl-1,2,4-oxadiazoles from carbamoyl-amidoximes and chlorides or anhydrides of haloacetic acids was developed. The reactions of 3-carbamoyl-5-trichloromethyl-1,2,4-oxadiazoles with amines and N,N-dimethylhydrazine were studied.