1,4,5,6-Tetrahydro-benzo[1,2-c;3,4-c']dipyrazole-3-carboxylic acid amide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,4,5,6-Tetrahydro-benzo[1,2-c;3,4-c']dipyrazole-3-carboxylic acid amide
• 英文别名: Tetrahydro-benzodipyrazole deriv. 7g；2,4,5,6-tetrahydropyrazolo[3,4-e]indazole-3-carboxamide
• 化学式: C₉H₉N₅O
• 分子量: 203.203
• InChiKey: JIJKUJLHCJAURU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  100
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,4,5,6-Tetrahydro-benzo[1,2-c;3,4-c']dipyrazole-3-carboxylic acid amide 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.5h， 生成 1,6-Dihydro-benzo[1,2-c;3,4-c']dipyrazole-3-carboxylic acid amide
  参考文献：
  名称：

  Benzodipyrazoles: a new class of potent CDK2 inhibitors

  摘要：

  The synthesis and the preliminary expansion of this new class of CDK2 inhibitors are presented. The synthesis was accomplished using a solution-phase protocol amenable to rapid parallel expansion and suitable to be scaled-up in view of possible lead development. Following a medicinal chemistry program aimed at improving cell permeability and selectivity, a series of compounds with nanomolar activity in the biochemical assay and able to efficiently inhibit tumor cell proliferation has been obtained.

  DOI：

  10.1016/j.bmcl.2005.01.023
• 作为产物：
  描述：

  1,4,5,6-Tetrahydro-benzo[1,2-c;3,4-c']dipyrazole-3-carboxylic acid ethyl ester 在 ammonium hydroxide 作用下， 以 甲醇 为溶剂， 生成 1,4,5,6-Tetrahydro-benzo[1,2-c;3,4-c']dipyrazole-3-carboxylic acid amide
  参考文献：
  名称：

  Benzodipyrazoles: a new class of potent CDK2 inhibitors

  摘要：

  The synthesis and the preliminary expansion of this new class of CDK2 inhibitors are presented. The synthesis was accomplished using a solution-phase protocol amenable to rapid parallel expansion and suitable to be scaled-up in view of possible lead development. Following a medicinal chemistry program aimed at improving cell permeability and selectivity, a series of compounds with nanomolar activity in the biochemical assay and able to efficiently inhibit tumor cell proliferation has been obtained.

  DOI：

  10.1016/j.bmcl.2005.01.023

文献信息

• Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2
  申请人：Pharmacia Corporation

  公开号：US20040127492A1

  公开（公告）日：2004-07-01

  Cyclic pyrazole compounds are described which inhibit mitogen activated protein kinase-activated protein kinase-2 (MK-2). Methods of making such compounds are described, as well as a method of using them for the inhibition of MK-2 in a subject in need of such inhibition, where the method involves administering to the subject an MK-2 inhibiting compound of the present invention. Pharmaceutical compositions and kits which contain the present MK-2 inhibiting compounds are also described.

  本发明涉及一种环状吡唑化合物，其能够抑制丝裂原活化蛋白激酶激活蛋白激酶-2（MK-2）。本发明还描述了制备这种化合物的方法，以及一种使用它们来抑制需要这种抑制的受体的方法，其中该方法涉及向受体中注射本发明的MK-2抑制化合物。本发明还描述了包含本MK-2抑制化合物的药物组合物和工具箱。
• Tricyclic pyrazole derivatives, process for their preparation and their use as antitumor agents
  申请人：D'Alessio Roberto

  公开号：US20050176796A1

  公开（公告）日：2005-08-11

  Compounds which are tricyclic pyrazole derivatives and analogues thereof, as set forth in the specification, or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.

  本发明揭示了三环吡唑衍生物及其类似物或药学上可接受的盐，以及包含它们的制药组合物；这些化合物或组合物在治疗由改变的蛋白激酶活性引起和/或相关的疾病方面具有用途，例如癌症、细胞增殖性疾病、阿尔茨海默病、病毒感染、自身免疫疾病和神经退行性疾病。
• TRICYCLIC PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1478357A2

  公开（公告）日：2004-11-24
• [EN] TRICYCLIC PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS<br/>[FR] DERIVES DE PYRAZOLE TRICYCLIQUE, PROCEDES DE LEUR PREPARATION ET LEUR UTILISATION EN TANT QU'AGENTS ANTI-TUMORAUX
  申请人：PHARMACIA ITALIA SPA

  公开号：WO2003070236A2

  公开（公告）日：2003-08-28

  Compounds which are tricyclic pyrazole derivatives and analogues thereof, as set forth in the specification, or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.
• Benzodipyrazoles: a new class of potent CDK2 inhibitors
  作者：Roberto D’Alessio、Alberto Bargiotti、Suzanne Metz、M. Gabriella Brasca、Alexander Cameron、Antonella Ermoli、Aurelio Marsiglio、Paolo Polucci、Fulvia Roletto、Marcellino Tibolla、Michael L. Vazquez、Anna Vulpetti、Paolo Pevarello

  DOI：10.1016/j.bmcl.2005.01.023

  日期：2005.3

  The synthesis and the preliminary expansion of this new class of CDK2 inhibitors are presented. The synthesis was accomplished using a solution-phase protocol amenable to rapid parallel expansion and suitable to be scaled-up in view of possible lead development. Following a medicinal chemistry program aimed at improving cell permeability and selectivity, a series of compounds with nanomolar activity in the biochemical assay and able to efficiently inhibit tumor cell proliferation has been obtained.