6,8-diprenyleriodictyol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 6,8-diprenyleriodictyol
• 英文别名: 6,8-diprenyl-5,7,3′ ,4′ -tetrahydroxyflavanone；5,7,3',4'-Tetrahydroxy-6,8-di-C-prenylflavanone；2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
• 化学式: C₂₅H₂₈O₆
• 分子量: 424.494
• InChiKey: WWFVAIXZPACOBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6,8-diprenyleriodictyol 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以20 mg的产率得到dorsmanin E
  参考文献：
  名称：

  Prenylated flavanones from the twigs of Dorstenia mannii

  摘要：

  Investigation of the twigs of Dorstenia mannii gave 6,8-diprenyl-5,7,3'4'-tetrahydroxyflavanone and four new prenylated flavanones, named dorsmanins E-H and characterized as 5,6-7,8-bis-(2,2-dimethylchromano)-3',4'-dihydroxyflavanone, 7,8-[2 "-(1-hydroxy-1-methylethyl)-dihydrofurano]-6-prenyl-5,3',4'-trihydroxyflavanone, 6,7-[2 "-(1-hydroxy-1-methylethyl)dihydrofurano]-8-prenyl-5,3',4'-trihydroxyflavanone and 6-prenyl-8-(2-hydroxy-3-methylbut-3-enyl)-5,7,3',4'-tetrahydroxyflavanone, respectively, on the basis of spectral analysis and chemical evidence for the chromano derivative. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0031-9422(98)00324-0

文献信息

• PRENYLFLAVONOIDE ZUR BEHANDLUNG EINES MELANOMS
  申请人：Eberhard Karls Universität Tübingen Medizinische Fakultät

  公开号：EP2991643A1

  公开（公告）日：2016-03-09
• FLUORIDE-FREE ANTICAVITY ORAL CARE COMPOSITIONS
  申请人：The Procter & Gamble Company

  公开号：EP4037781A1

  公开（公告）日：2022-08-10
• ORAL CARE COMPOSITIONS COMPRISING HOPS BETA ACID AND FLUORIDE
  申请人：The Procter & Gamble Company

  公开号：EP4037778A1

  公开（公告）日：2022-08-10
• PHARMACEUTICAL COMPOSITION
  申请人：Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet

  公开号：US20160067211A1

  公开（公告）日：2016-03-10

  The present invention relates to a pharmaceutical composition for the prophylaxis and/or treatment of a melanoma and a precursor thereof as well as a skin and mucosa metastasis and uses and methods associated therewith.
• Oral Care Compositions Comprising Hops Beta Acids And Fluoride Ions
  申请人：The Procter & Gamble Company

  公开号：US20210093525A1

  公开（公告）日：2021-04-01

  Oral care compositions with an anticaries or anticavity effect. Oral care compositions that are have an extract from a species in the Humulus family and an anticaries drug, such as a fluoride ion source. Oral care compositions have fluoride and hops beta acid, such as from an extract from Humulus lupulus . Oral care compositions have a fluoride ion source and a hops beta acid derived from an extract of Humulus lupulus.