New tetrahydrofurancarboxylic acid derivatives of the formula:
wherein
R1 is amino or a protected amino group,
R2 is amino or acylamino and
R3 is carboxy or a protected carboxy group or a pharmaceutically acceptable salt thereof, and processes for their preparation, and also a pharmaceutical composition comprising, as an effective ingredient, the above compound in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient. The invention also relates to the microorganism Chrysosporium pannormu ATCC 20617 and to starting compounds of the formula
and their preparation.
式中的新
四氢呋喃羧酸衍
生物:
式中
R1 是
氨基或受保护的
氨基、
R2 是
氨基或酰
氨基,以及
R3为羧基或受保护的羧基或其药学上可接受的盐及其制备方法,以及一种药物组合物,其有效成分包括上述化合物与药学上可接受的、基本上无毒的载体或赋形剂。本发明还涉及微
生物 Chrysosporium pannormu A
TCC 20617 和起始化合物式
及其制备。