2-phenoxy-1-(piperazin-1-yl)ethanone trifluoroacetate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-phenoxy-1-(piperazin-1-yl)ethanone trifluoroacetate
• 英文别名: 2-Phenoxy-1-piperazin-1-ylethanone;2,2,2-trifluoroacetic acid
• 化学式: C₂HF₃O₂*C₁₂H₁₆N₂O₂
• 分子量: 334.295
• InChiKey: RYIJGYARMMAWGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.13
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  对甲苯磺酰氯 、 2-phenoxy-1-(piperazin-1-yl)ethanone trifluoroacetate 在 吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 生成 1-phenoxyacetyl-4-tosylpiperazine
  参考文献：
  名称：

  Generation of rhodium carbenoids on a polystyrene support and their OH-insertion reaction with alcohols

  摘要：

  A rhodium carbenoid attached to a polystyrene resin was generated by treatment of a resin-bound diazoacetamide with rhodium(II) acetate in dichloromethane. This immobilized reactive species underwent OH-insertion reactions with alcohols to yield ethers of high purity. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0040-4020(96)00230-x
• 作为产物：
  描述：

  三氟乙酸 、 苯酚 、 alkaline earth salt of/the/ methylsulfuric acid 在 rhodium(II) acetate dimer 、 四氢吡咯 、 对甲苯磺酰叠氮 、 N,N-二异丙基乙胺 作用下， 生成 2-phenoxy-1-(piperazin-1-yl)ethanone trifluoroacetate
  参考文献：
  名称：

  Generation of rhodium carbenoids on a polystyrene support and their OH-insertion reaction with alcohols

  摘要：

  A rhodium carbenoid attached to a polystyrene resin was generated by treatment of a resin-bound diazoacetamide with rhodium(II) acetate in dichloromethane. This immobilized reactive species underwent OH-insertion reactions with alcohols to yield ethers of high purity. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0040-4020(96)00230-x

文献信息

• Generation of rhodium carbenoids on a polystyrene support and their OH-insertion reaction with alcohols
  作者：Florencio Zaragoza、S USAnne Vejle Petersen

  DOI：10.1016/0040-4020(96)00230-x

  日期：1996.4

  A rhodium carbenoid attached to a polystyrene resin was generated by treatment of a resin-bound diazoacetamide with rhodium(II) acetate in dichloromethane. This immobilized reactive species underwent OH-insertion reactions with alcohols to yield ethers of high purity. Copyright (C) 1996 Elsevier Science Ltd