1,5-bis(4-iodophenoxy)pentane | 415938-12-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,5-bis(4-iodophenoxy)pentane
• 英文别名: 1-Iodo-4-[5-(4-iodophenoxy)pentoxy]benzene
• CAS: 415938-12-4
• 化学式: C₁₇H₁₈I₂O₂
• 分子量: 508.138
• InChiKey: QTNZUKUJIGJGQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,5-bis(4-iodophenoxy)pentane 、 三甲基乙炔基硅 在 copper(l) iodide 、 四(三苯基膦)钯 、 正丁胺 、 potassium carbonate 作用下， 以 甲醇 、 乙醚 为溶剂， 反应 6.0h， 以71%的产率得到1,5-bis(4-ethynylphenoxy)pentane
  参考文献：
  名称：

  Synthesis and biological evaluation of novel symmetry bis-enediynes

  摘要：

  A series of acyclic symmetry bis-enediynes have been synthesized successfully and their bioactivities were evaluated. Among them, 1,6-bis(4-((2-(pyridin-2-ylethynyl)phenyl)ethynyl)phenoxy)hexane 8g showed good inhibition activity against the CCRF-CEM (GI(50) = 0.04 mu M) and HL-60 (GI(50) = 0.09 mu M) Cell lines of human leukemia. The cell cycle analysis shows that compound 8g arrests cell cycle via inhibiting Cyclin A and Cyclin B expressions in low concentration and induces a significant apoptosis progress in high concentration. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.03.005
• 作为产物：
  描述：

  1,5-二溴戊烷 、 4-碘苯酚 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以70%的产率得到1,5-bis(4-iodophenoxy)pentane
  参考文献：
  名称：

  Synthesis and biological evaluation of novel symmetry bis-enediynes

  摘要：

  A series of acyclic symmetry bis-enediynes have been synthesized successfully and their bioactivities were evaluated. Among them, 1,6-bis(4-((2-(pyridin-2-ylethynyl)phenyl)ethynyl)phenoxy)hexane 8g showed good inhibition activity against the CCRF-CEM (GI(50) = 0.04 mu M) and HL-60 (GI(50) = 0.09 mu M) Cell lines of human leukemia. The cell cycle analysis shows that compound 8g arrests cell cycle via inhibiting Cyclin A and Cyclin B expressions in low concentration and induces a significant apoptosis progress in high concentration. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.03.005

文献信息

• Synthesis and biological evaluation of novel symmetry bis-enediynes
  作者：Kuo-Feng Tseng、Chi-Fong Lin、Yu-Hsiang Lo、Yi-Ling Hu、Li-Yi Chen、Sheng-Huei Yang、Shinne-Ren Lin、Long-Sen Chang、Ming-Jung Wu

  DOI：10.1016/j.ejmech.2008.03.005

  日期：2009.1

  A series of acyclic symmetry bis-enediynes have been synthesized successfully and their bioactivities were evaluated. Among them, 1,6-bis(4-((2-(pyridin-2-ylethynyl)phenyl)ethynyl)phenoxy)hexane 8g showed good inhibition activity against the CCRF-CEM (GI(50) = 0.04 mu M) and HL-60 (GI(50) = 0.09 mu M) Cell lines of human leukemia. The cell cycle analysis shows that compound 8g arrests cell cycle via inhibiting Cyclin A and Cyclin B expressions in low concentration and induces a significant apoptosis progress in high concentration. (C) 2008 Elsevier Ltd. All rights reserved.