(2-(4-溴苯基)咪唑[1,2-A]吡啶-3-基)甲胺 | 824413-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: (2-(4-溴苯基)咪唑[1,2-A]吡啶-3-基)甲胺
• 英文名称: (2-(4-bromophenyl)imidazo[1,2-a]pyridin-3-yl)methanamine
• 英文别名: [2-(4-bromophenyl)imidazo[1,2-a]pyridin-3-yl]methanamine
• CAS: 824413-92-5
• 化学式: C₁₄H₁₂BrN₃
• 分子量: 302.173
• InChiKey: JJMNJHSETVNICF-UHFFFAOYSA-N

物化性质

• 密度：
  1.53±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  43.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4-(2-(dimethylamino)ethylamino)-1H-pyrrol-2(5H)-one 、 (2-(4-溴苯基)咪唑[1,2-A]吡啶-3-基)甲胺 生成 1-((2-(4-bromophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-4-(2-(dimethylamino)ethylamino)-1H-pyrrol-2(5H)-one
  参考文献：
  名称：

  IMIDAZO[1,2-a]PYRIDINE COMPOUNDS

  摘要：

  本发明揭示了咪唑并[1,2-a]吡啶类化合物。该发明的化合物是有用的治疗剂，揭示了它们在制药配方中的包含以及在治疗方法中的使用。

  公开号：

  US20110166146A1
• 作为产物：
  描述：

  在 盐酸 作用下， 以 乙醚 为溶剂， 生成 (2-(4-溴苯基)咪唑[1,2-A]吡啶-3-基)甲胺
  参考文献：
  名称：

  Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors

  摘要：

  A new series of DPP‐4 inhibitors with imidazo[1,2‐a]pyridine scaffold were designed by exploiting scaffold hopping strategy and docking study. Based on docking binding model, structural modifications of 2‐benzene ring and pyridine moieties of compound 5a led to the identification of compound 5d with 2, 4‐dichlorophenyl group at the 2‐position as a potent (IC50 = 0.13 μm), selective (DPP‐8/DPP‐4 = 215 and DPP‐9/DPP‐4 = 192) and in vivo efficacious DPP‐4 inhibitor. Further, molecular docking revealed that compound 5d could retain key binding features of DPP‐4 with the pyridine moiety of imidazo[1,2‐a]pyridine ring providing an additional π−π interaction with Phe357 of DPP‐4. Compound 5d might be a promising lead for further development of novel DPP‐4 inhibitor treating T2DM.

  DOI：

  10.1111/cbdd.12560

文献信息

• Imidazo[1,2-a]pyridine compounds
  申请人：Fang Qun Kevin

  公开号：US08497278B2

  公开（公告）日：2013-07-30

  Imidazo[1,2-a]pyridines are disclosed. Compounds of the invention are useful therapeutic agents and their inclusion in pharmaceutical formulations and use in methods of treatment are disclosed. Many of the compounds disclosed herein may be represented by the following generic formula: in which Y is a direct bond or heteroatom and A3 is usually a nitrogenous heterocycle.

  本发明公开了咪唑并[1,2-a]吡啶类化合物。本发明的化合物是有用的治疗剂，公开了它们在制药配方中的包含和在治疗方法中的使用。这里公开的许多化合物可以用以下通用式表示：其中Y是直接键或杂原子，A3通常是氮杂环。
• IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS GABA-A RECEPTOR MODULATORS
  申请人：Sepracor Inc.

  公开号：EP2300470A2

  公开（公告）日：2011-03-30
• US8497278B2
  申请人：——

  公开号：US8497278B2

  公开（公告）日：2013-07-30
• [EN] IMIDAZO[1,2-a]PYRIDINE COMPOUNDS<br/>[FR] COMPOSÉS IMIDAZO[1,2-A]PYRIDINES
  申请人：SEPRACOR INC

  公开号：WO2009143156A2

  公开（公告）日：2009-11-26

  Imidazo[1,2-a]pyridines are disclosed. Compounds of the invention are useful therapeutic agents and their inclusion in pharmaceutical formulations and use in methods of treatment are disclosed.