morpholin-4-yl-(2-phenylcyclopropyl)methanone | 92250-72-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: morpholin-4-yl-(2-phenylcyclopropyl)methanone
• 英文别名: 4-(2-phenyl-cyclopropanecarbonyl)-morpholine；Morpholin-4-yl(2-phenylcyclopropyl)methanone
• CAS: 92250-72-1
• 化学式: C₁₄H₁₇NO₂
• mdl: MFCD00848909
• 分子量: 231.294
• InChiKey: XFELRKSEVQXDDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-苯基环丙烷羰酰氯 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成 morpholin-4-yl-(2-phenylcyclopropyl)methanone
  参考文献：
  名称：

  Chemoselective Nucleophilic Attack on N-Acyl Derivatives of (S)-Ethyl 4,4-Dimethyl Pyroglutamate (DMPG)

  摘要：

  [GRAPHICS]Heteronucleophiles and C-nucleophiles chemoselectively react with n-acyl (S)-ethyl 4,4-dimethyl pyroglutamate (DMPG) affording esters, amides, and ketones in high yield. The intramolecular process allows the stereoselective formation of beta-hydroxy acids likely by formation and ring opening of the corresponding beta-lactones.

  DOI：

  10.1021/ol034847m

文献信息

• Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate
  申请人：Zhang X. Peter

  公开号：US20120077959A1

  公开（公告）日：2012-03-29

  Cobalt(II) complexes of the D 2 -symmetric chiral porphyrins are effective catalysts for asymmetric cyclopropanation reactions with succinimidyl diazoacetate. The Co-catalyzed reaction is suitable for various olefins, providing the corresponding cyclopropane succinimidyl esters in high yields and excellent diastereo- and enantio-selectivity. The resulting enantioenriched cyclopropane succinimidyl esters can serve as convenient synthons for the general synthesis of optically active cyclopropyl carboxamides through mild reactions with a wide range of amine derivatives, including unprotected peptides and amino sugars
• [EN] ASYMMETRIC CYCLOPROPANATION WITH SUCCINIMIDYL DIAZOACETATE<br/>[FR] CYCLOPROPANATION ASYMÉTRIQUE AVEC DU DIAZOACÉTATE DE SUCCINIMIDYLE
  申请人：UNIV SOUTH FLORIDA

  公开号：WO2010094029A2

  公开（公告）日：2010-08-19

  Cobalt(ll) complexes of the D2-symmetric chiral porphyrins are effective catalysts for asymmetric cyclopropanation reactions with succinimidyl diazoacetate. The Co-catalyzed reaction is suitable for various olefins, providing the corresponding cyclopropane succinimidyl esters in high yields and excellent diastereo- and enantio-selectivity. The resulting enantioenriched cyclopropane succinimidyl esters can serve as convenient synthons for the general synthesis of optically active cyclopropyl carboxamides through mild reactions with a wide range of amine derivatives, including unprotected peptides and amino sugars