2-(4-fluorophenyl)-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-fluorophenyl)-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazine
• 英文别名: 2-(4-Fluorophenyl)-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazine
• 化学式: C₁₂H₁₁FN₂O
• 分子量: 218.231
• InChiKey: KKFJCMMODSEUDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-fluorophenyl)-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazine 在 N-碘代丁二酰亚胺 作用下， 以 乙腈 为溶剂， 反应 12.0h， 生成 2-(4-fluorophenyl)-3-iodo-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazine
  参考文献：
  名称：

  [EN] ANALOGS FOR THE TREATMENT OF DISEASE
  [FR] ANALOGUES POUR LE TRAITEMENT D'UNE MALADIE

  摘要：

  Provided are TNIK and/or MAP4K4 kinases inhibitors for the treatment of disease. In one aspect, disclosed herein are kinase inhibitors having a structure of Formulas (A), (A*), (I), (II), (AA), (B), (C), (D), (B*), (C*) and (D*). Further described herein are pharmaceutical composition comprising these compounds and methods of using these compounds. In one aspect, disclosed herein are methods of treating a disease or condition by administering the kinases inhibitors described herein.

  公开号：

  WO2022179529A1
• 作为产物：
  描述：

  5,6-二氢-2H-1,4-恶嗪-3-胺 、 2-溴-4'-氟苯乙酮 以 异丙醇 为溶剂， 生成 2-(4-fluorophenyl)-6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazine
  参考文献：
  名称：

  [EN] ANALOGS FOR THE TREATMENT OF DISEASE
  [FR] ANALOGUES POUR LE TRAITEMENT D'UNE MALADIE

  摘要：

  Provided are TNIK and/or MAP4K4 kinases inhibitors for the treatment of disease. In one aspect, disclosed herein are kinase inhibitors having a structure of Formulas (A), (A*), (I), (II), (AA), (B), (C), (D), (B*), (C*) and (D*). Further described herein are pharmaceutical composition comprising these compounds and methods of using these compounds. In one aspect, disclosed herein are methods of treating a disease or condition by administering the kinases inhibitors described herein.

  公开号：

  WO2022179529A1

文献信息

• [EN] NOVEL SUBSTITUTED IMIDAZOLES AS CASEIN KINASE 1 δ/&egr; INHIBITORS<br/>[FR] UTILISATION DE NOUVEAUX IMIDAZOLES SUBSTITUÉS COMME INHIBITEURS DE LA CASÉINE KINASE 1 &Dgr;/&Egr;
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014100533A1

  公开（公告）日：2014-06-26

  The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.

  这项发明提供了式（I）的化合物及其药学上可接受的盐。式（I）的化合物通过抑制蛋白激酶活性，因此可用作抗癌药物。
• NOVEL SUBSTITUTED IMIDAZOLES AS CASEIN KINASE 1 D/E INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150344481A1

  公开（公告）日：2015-12-03

  The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.

  本发明提供了公式（I）的化合物及其药学上可接受的盐。公式（I）的化合物抑制蛋白激酶活性，因此使它们作为抗癌剂有用。
• NOVEL SUBSTITUTED IMIDAZOLES AS CASEIN KINASE 1 / INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2935271A1

  公开（公告）日：2015-10-28
• US9556179B2
  申请人：——

  公开号：US9556179B2

  公开（公告）日：2017-01-31