(1R,3S)-3-Phenyl-indan-1-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (1R,3S)-3-Phenyl-indan-1-ol
• 英文别名: (1R,3S)-3-phenyl-2,3-dihydro-1H-inden-1-ol
• 化学式: C₁₅H₁₄O
• 分子量: 210.276
• InChiKey: DBSYDARJANONJR-LSDHHAIUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-苯基-1-茚酮 在 (S)-prolinol core-containing second-generation dendrimer dimethyl sulfide borane 作用下， 以 四氢呋喃 为溶剂， 反应 0.8h， 生成 (1R,3R)-3-phenyl-2,3-dihydro-1H-inden-1-ol 、 (1S,3R)-3-Phenyl-indan-1-ol 、 (1S,3S)-3-phenyl-2,3-dihydro-1H-inden-1-ol 、 (1R,3S)-3-Phenyl-indan-1-ol
  参考文献：
  名称：

  Asymmetric reduction of substituted indanones and tetralones catalyzed by chiral dendrimer and its application to the synthesis of (+)-sertraline

  摘要：

  A recoverable dendrimeric supported prolinol was used as a catalyst in the asymmetric reduction of indanones and tetralones to give separable cis and trans isomers up to 97% ee. This method was also applied in the enantio selective synthesis of the antidepressant drug (+)-sertraline. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.07.010

文献信息

• Asymmetric reduction of substituted indanones and tetralones catalyzed by chiral dendrimer and its application to the synthesis of (+)-sertraline
  作者：Guangyin Wang、Changwu Zheng、Gang Zhao

  DOI：10.1016/j.tetasy.2006.07.010

  日期：2006.8

  A recoverable dendrimeric supported prolinol was used as a catalyst in the asymmetric reduction of indanones and tetralones to give separable cis and trans isomers up to 97% ee. This method was also applied in the enantio selective synthesis of the antidepressant drug (+)-sertraline. (c) 2006 Elsevier Ltd. All rights reserved.