1,2-Diamino-4-(p-chlor-phenyl)-imidazol | 15970-42-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,2-Diamino-4-(p-chlor-phenyl)-imidazol
• 英文别名: 4-(4-chlorophenyl)-1H-imidazole-1,2-diamine；4-(4-chlorophenyl)imidazole-1,2-diamine
• CAS: 15970-42-0
• 化学式: C₉H₉ClN₄
• 分子量: 208.65
• InChiKey: XWTCRCUFBKCSJP-UHFFFAOYSA-N

物化性质

• 沸点：
  478.1±37.0 °C(Predicted)
• 密度：
  1.50±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,2-Diamino-4-(p-chlor-phenyl)-imidazol 以73%的产率得到
  参考文献：
  名称：

  POVSTYANOJ M. V.; KOCHERGIN P. M.; KRUGLENKO V. P.; PRIJMENKO B. A., IZV. VYSSH. UCHEB. ZAVEDENIJ. XIMIYA I XIM. TEXNOL. , 1975, 18, +

  摘要：

  DOI：

文献信息

• 3-deoxyglucosone and skin
  申请人：——

  公开号：US20030219440A1

  公开（公告）日：2003-11-27

  The invention relates to a method of removing 3-deoxyglucosone and other alpha-dicarbonyl sugars from skin. The invention further relates to methods of inhibiting production and function of 3-deoxyglucosone and other alpha-dicarbonyl sugars in skin. The invention also relates to methods of treating 3-deoxyglucosone and other alpha-dicarbonyl sugars associated diseases and disorders of skin.

  该发明涉及一种从皮肤中去除3-去氧葡萄糖酮和其他α-二酮糖的方法。该发明还涉及抑制皮肤中3-去氧葡萄糖酮和其他α-二酮糖的产生和功能的方法。该发明还涉及治疗与皮肤相关的3-去氧葡萄糖酮和其他α-二酮糖相关疾病和障碍的方法。
• Imidazole derivatives, their preparation and their use as
  申请人：Novartis AG

  公开号：US05840911A1

  公开（公告）日：1998-11-24

  Described are compounds of formula I ##STR1## wherein R.sub.1 is hydrogen or hydroxy; R.sub.2, R.sub.2 ' and R.sub.2 " are each independently of the others hydrogen or a substituent other than hydrogen; either R.sub.3 is hydrogen or a substituent other than hydrogen and R.sub.4 is hydrogen or lower alkyl, or R.sub.3 and R.sub.4 together form a divalent radical of the formula --(CH.sub.2).sub.n -- wherein n is 2 or 3; R.sub.5 and R.sub.6 are each independently of the other hydrogen, alkyl or aryl; and either R.sub.7 and R.sub.8 are each hydrogen, or R.sub.7 and R.sub.8 together form a bond; tautomers thereof, provided that at least one tautomerisable group is present; and salts thereof. The compounds inhibit the enzyme S-adenosylmethionine decarboxylase and are suitable, for example, for the treatment of tumours and protozoal infections.

  描述的是式I的化合物##STR1##其中R.sub.1是氢或羟基；R.sub.2、R.sub.2'和R.sub.2"各自独立地是氢或除氢以外的取代基；R.sub.3要么是氢要么是除氢以外的取代基，而R.sub.4是氢或较低的烷基，或者R.sub.3和R.sub.4一起形成式--(CH.sub.2).sub.n--的二价基团，其中n为2或3；R.sub.5和R.sub.6各自独立地是氢、烷基或芳基；而R.sub.7和R.sub.8要么各自是氢，要么R.sub.7和R.sub.8一起形成键；其互变异构体，只要至少存在一个互变异构基团；以及其盐。这些化合物抑制S-腺苷甲硫氨酸脱羧酶酶，并适用于例如治疗肿瘤和原虫感染。
• Fructoseamine 3 kinase and the formation of collagen and elastin
  申请人：Tobia Annette

  公开号：US20070065443A1

  公开（公告）日：2007-03-22

  The invention relates to the discovery that levels of collagen and elastin can be modulated by changing the flux through the Amadori Pathway and that copper containing compounds and complexes inhibit the enzyme fructoseamine-3-kinase.

  本发明涉及到一项发现，即通过改变Amadori途径的通量可以调节胶原蛋白和弹性蛋白的水平，并且含铜化合物和配合物可以抑制酶果糖胺-3-激酶。
• Method for reducing a susceptibility to tumor formation induced by 3-deoxyglucosone and precursors thereof
  申请人：Brown R. Truman

  公开号：US20060089316A1

  公开（公告）日：2006-04-27

  Disclosed are methods of using various compounds, which are known to bind to 3-deoxyglucosone (3DG) or precursors thereof, in order to reduce a susceptibility to tumor formation and/or to prevent or delay onset of tumor formation induced by 3DG and its precursors. Also disclosed is the reduction of 3DG levels in high fructose corn syrop so that the high fructose corn syrup is less likely to induce tumor formation.

  公开了使用各种已知与3-脱氧葡萄糖酮（3DG）或其前体结合的化合物的方法，以减少对肿瘤形成的易感性和/或预防或延迟由3DG及其前体诱导的肿瘤形成。还公开了降低高果糖玉米糖浆中3DG水平的方法，以使高果糖玉米糖浆不太可能诱导肿瘤形成。
• KRUGLENKO V. P.; POVSTYANOJ M. V.; TURCHIN V. I.; KONOVALOVA L. I., XIMIYA GETEROTSIKL. SOEDIN., 1978, HO 11, 1565
  作者：KRUGLENKO V. P.、 POVSTYANOJ M. V.、 TURCHIN V. I.、 KONOVALOVA L. I.

  DOI：——

  日期：——