medrol acetate | 53-36-1

• 物质功能分类: 原料药 - 激素及调节内分泌功能类药 - 肾上腺皮质激素类药
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: medrol acetate
• 英文别名: [2-(11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl] acetate
• CAS: 53-36-1
• 化学式: C₂₄H₃₂O₆
• 分子量: 416.514
• InChiKey: PLBHSZGDDKCEHR-UHFFFAOYSA-N

物化性质

• 熔点：
  192-195°C
• 比旋光度：
  D20 +101° (dioxane)
• 沸点：
  454.82°C (rough estimate)
• 密度：
  1.1156 (rough estimate)
• 溶解度：
  几乎不溶于水，微溶于丙酮和乙醇（96%）。

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  6

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S24/25
• 危险类别码：
  R63,R62
• 海关编码：
  32041200
• WGK Germany：
  3
• 储存条件：
  Refrigerator

SDS

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Section 1. Chemical Product and Company Identification
Methylprednisolone acetate Catalog
ME171
Common Name/
Number(s).
Trade Name
CAS# 53-36-1
Manufacturer
RTECS TU4154050
SPECTRUM CHEMICAL MFG. CORP.
TSCA TSCA 8(b) inventory:
Methylprednisolone acetate
Commercial Name(s) Not available.
CI# Not available.
Synonym 11,17,21-Trihydroxy-6-methyl-1,4-pregnadiene-3,20-dione acetate
IN CASE OF EMERGENCY
Not available.
Chemical Name
Chemical Family Not available. CALL [phone]
C24H32O6
Chemical Formula
SPECTRUM CHEMICAL MFG. CORP.

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Section 2.Composition and Information on Ingredients
Exposure Limits
TWA (mg/m3) STEL (mg/m3) CEIL (mg/m3)
Name CAS # % by Weight
1) Methylprednisolone acetate 53-36-1 100
Toxicological Data Methylprednisolone acetate
on Ingredients LD50: Not available.
LC50: Not available.

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Section 3. Hazards Identification
Potential Acute Health Effects Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation.
Potential Chronic Health Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of ingestion, of inhalation.
Effects CARCINOGENIC EFFECTS: Not available.
MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Methylprednisolone acetate

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Section 4. First Aid Measures
Eye Contact Check for and remove any contact lenses. Do not use an eye ointment. Seek medical attention.
Skin Contact After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin
with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.
Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated
clothing before reusing.
Serious Skin Contact Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical
attention.
Inhalation Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation Not available.
Ingestion Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not
breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.
Serious Ingestion Not available.

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Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash Points Not available.
Flammable Limits Not available.
These products are carbon oxides (CO, CO2).
Products of Combustion
Fire Hazards in Presence of Not available.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
of Various Substances Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media SMALL FIRE: Use DRY chemical powder.
and Instructions LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Not available.
Fire Hazards
Special Remarks on Explosion Not available.
Hazards

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Section 6. Accidental Release Measures
Small Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
Methylprednisolone acetate

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Section 7. Handling and Storage
Precautions Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the
residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Wear suitable
protective clothing In case of insufficient ventilation, wear suitable respiratory equipment If you feel unwell, seek
medical attention and show the label when possible. Avoid contact with skin and eyes
Storage Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly
closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat
and away from strong oxidizing agents.

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Section 8. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spill to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits Not available.

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Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Crystalline solid.) Odor Not available.
Taste Not available.
416.51 g/mole
Molecular Weight
Color White.
pH (1% soln/water) Not applicable.
Boiling Point Decomposes.
Melting Point 206°C (402.8°F)
Critical Temperature Not available.
Specific Gravity Not available.
Not applicable.
Vapor Pressure
Vapor Density Not available.
Volatility Not available.
Odor Threshold Not available.
Water/Oil Dist. Coeff. Not available.
Not available.
Ionicity (in Water)
Dispersion Properties Not available.
Very slightly soluble in methanol, acetone.
Solubility
Insoluble in cold water.

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Section 10. Stability and Reactivity Data
Stability The product is stable.
Instability Temperature Not available.
Conditions of Instability Not available.
Incompatibility with various Not available.
substances
Methylprednisolone acetate
Non-corrosive in presence of glass.
Corrosivity
Special Remarks on Not available.
Reactivity
Special Remarks on Not available.
Corrosivity
No.
Polymerization

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Section 11. Toxicological Information
Routes of Entry Dermal contact. Eye contact. Inhalation. Ingestion.
Toxicity to Animals LD50: Not available.
LC50: Not available.
Chronic Effects on Humans Not available.
Other Toxic Effects on Hazardous in case of skin contact (irritant, permeator), of ingestion, of inhalation.
Humans
Special Remarks on Not available.
Toxicity to Animals
Special Remarks on Not available.
Chronic Effects on Humans
Special Remarks on other Not available.
Toxic Effects on Humans

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Section 12. Ecological Information
Not available.
Ecotoxicity
BOD5 and COD Not available.
Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
Toxicity of the Products The products of degradation are more toxic.
of Biodegradation
Special Remarks on the Not available.
Products of Biodegradation

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Section 13. Disposal Considerations
Waste Disposal

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Section 14. Transport Information
DOT Classification Not a DOT controlled material (United States).
Identification Not applicable.
Special Provisions for Not applicable.
Transport
Methylprednisolone acetate
DOT (Pictograms)

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Section 15. Other Regulatory Information and Pictograms
TSCA 8(b) inventory: Methylprednisolone acetate
Federal and State
Regulations
California California prop. 65: This product contains the following ingredients for which the State of California has found
to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found
to cause birth defects which would require a warning under the statute: No products were found.
Other Regulations Not available..
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
DSCL (EEC) R36/38- Irritating to eyes and skin.
Health Hazard
HMIS (U.S.A.) 2 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
2 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.
Methylprednisolone acetate

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

理化性质

醋酸甲泼尼龙是一种白色或几乎白色的结晶性粉末，无气味且初尝无味随后带苦。它易溶于无水乙醇和氯仿，几乎不溶于水。

作用机制

醋酸甲泼尼龙是人工合成的糖皮质激素。该药物能够扩散透过细胞膜，并与胞浆内特异受体结合形成复合物，随后进入细胞核并与DNA结合启动mRNA转录过程，进而合成多种酶蛋白。全身给药后，这些酶最终通过不同的作用机制发挥多种生理效应。

此外，糖皮质激素不仅对炎症和免疫过程有重要影响，还参与碳水化合物、蛋白质和脂肪的代谢，并对心血管系统、骨骼和肌肉系统以及中枢神经系统也有一定作用。

应用

醋酸甲泼尼龙具有较强的抗炎效果，但其钠潴留作用较弱，与泼尼松相似。甲泼尼龙醋酸酯混悬剂分解缓慢，作用持久，适用于肌内注射或关节腔内注射。而甲泼尼龙琥珀酸钠则为水溶性制剂，既可进行肌内注射也可静脉滴注。

反应信息

• 作为产物：
  描述：

  [2-(9-Bromo-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] acetate 在 2,2'-azobis(2-methylpropionamidine) hydrochloride 、 次磷酸 、 sodium carbonate 作用下， 以 2-甲基四氢呋喃 、 水 为溶剂， 以91.5%的产率得到medrol acetate
  参考文献：
  名称：

  9-卤代甾体化合物的脱卤方法及应用

  摘要：

  本发明提供了一种9‑卤代甾体化合物的脱卤方法及应用，涉及化学合成技术领域。9‑卤代甾体化合物的脱卤方法，包括如下步骤：化合物I与氢供体和偶氮类自由基引发剂反应，得到9‑卤代甾体化合物的9位脱卤产物化合物II。本发明提供的9‑卤代甾体化合物的脱卤方法，氢供体采用次磷酸及次磷酸盐、甲酸及甲酸盐、有机硅氢化物、肼类化合物或环己烯中的一种或几种的组合，引发剂采用偶氮类自由基引发剂，反应中未使用铬、二价铬盐、三价铬盐或氢化三丁基锡等毒性较大，对环境造成严重污染的试剂，绿色环保，合成工艺简便易行，提高了生产适用性。

  公开号：

  CN112142813A