4-(2-[diethylamino]-2-oxoethoxy)-3-methoxy-benzeneacetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(2-[diethylamino]-2-oxoethoxy)-3-methoxy-benzeneacetic acid
• 英文别名: (4-((Diethylcarbamoyl)methoxy)-3-methoxyphenyl)acetic acid；2-[4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl]acetic acid
• 化学式: C₁₅H₂₁NO₅
• 分子量: 295.335
• InChiKey: KGCLIEPBSVRBJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  丙酸氯甲酯 、 4-(2-[diethylamino]-2-oxoethoxy)-3-methoxy-benzeneacetic acid 以 丙酮 为溶剂， 反应 3.0h， 以42%的产率得到
  参考文献：
  名称：

  具有提高的药代动力学性能和麻醉性能的苯 基乙酸酯类化合物

  摘要：

  具有提高的药代动力学性能和麻醉性能的苯基乙酸酯类化合物。本发明提供一种式(I)所示的苯基乙酸酯类化合物。其中R1为L1OC(O)L2，L1为取代或未取代的C1‑C6烷基，L2为取代或未取代的C1‑C6烷基；R2为单卤代，多卤代或者未取代的C1‑C6烷基，C3‑C6环烷基，C2‑C6烯基或炔基；R3、R4各自独立地为(C1‑C6)烷基。本发明化合物具有短效镇静催眠以及麻醉的诱导和维持作用，且具有更短的麻醉后行为恢复时间。

  公开号：

  CN105272871B

文献信息

• FRAGRANCE COMPOSITIONS AND USES THEREOF
  申请人：The Procter & Gamble Company

  公开号：EP3103431A1

  公开（公告）日：2016-12-14

  The present invention relates to a composition having improved or enhanced fidelity and/or longevity of the fragrance profile, comprising fragrance materials in a diamond construction and at least one substantially non-odorous fragrance modulator. The invention also relates to methods of use of the compositions for perfuming suitable substrates, including hard surfaces and body parts, particularly skin and hair.

  本发明涉及一种具有改进或增强的香味保真度和/或持久性的组合物，该组合物由钻石结构的香味材料和至少一种基本无臭的香味调节剂组成。本发明还涉及组合物的使用方法，用于对合适的基底（包括硬表面和身体部位，特别是皮肤和头发）进行加香。
• ABSORBENT ARTICLE COMPRISING FRAGRANCE COMPOSITION
  申请人：The Procter & Gamble Company

  公开号：EP3103523A1

  公开（公告）日：2016-12-14

  The present invention relates to a an absorbent article comprising a fragrance composition having improved or enhanced fidelity and/or longevity of the fragrance profile, comprising fragrance materials in a diamond construction and at least one substantially non-odorous fragrance modulator.

  本发明涉及一种由香味组合物组成的吸收制品，该香味组合物具有改进或增强的香味保真度和/或持久性，包括钻石结构的香味材料和至少一种基本无臭的香味调节剂。
• Fragrance compositions and uses thereof
  申请人：The Procter & Gamble Company

  公开号：US10138441B2

  公开（公告）日：2018-11-27

  The present invention relates to a composition having improved or enhanced fidelity and/or longevity of the fragrance profile, comprising fragrance materials in a diamond construction and at least one substantially non-odorous fragrance modulator. The invention also relates to methods of use of the compositions for perfuming suitable substrates, including hard surfaces and body parts, particularly skin and hair.

  本发明涉及一种具有改进或增强的香味保真度和/或持久性的组合物，该组合物由钻石结构的香味材料和至少一种基本无臭的香味调节剂组成。本发明还涉及组合物的使用方法，用于对合适的基底（包括硬表面和身体部位，特别是皮肤和头发）进行加香。
• Fragrance Compositions and Uses Thereof
  申请人：The Procter & Gamble Company

  公开号：US20160362630A1

  公开（公告）日：2016-12-15

  The present invention relates to a composition having improved or enhanced fidelity and/or longevity of the fragrance profile, comprising fragrance materials in a diamond construction and at least one substantially non-odorous fragrance modulator. The invention also relates to methods of use of the compositions for perfuming suitable substrates, including hard surfaces and body parts, particularly skin and hair.
• [EN] FRAGRANCE COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS DE PARFUM ET LEURS UTILISATIONS
  申请人：PROCTER & GAMBLE

  公开号：WO2016200761A2

  公开（公告）日：2016-12-15

  The present invention relates to a composition having improved or enhanced fidelity and/or longevity of the fragrance profile, comprising fragrance materials in a diamond construction and at least one substantially non-odorous fragrance modulator. The invention also relates to methods of use of the compositions for perfuming suitable substrates, including hard surfaces and body parts, particularly skin and hair.