3,5-dimethyl-pyrazole-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3,5-dimethyl-pyrazole-1-carboxylic acid
• 英文别名: 3,5-Dimethyl-pyrazol-1-carbonsaeure；3,5-Dimethyl-1H-pyrazole-1-carboxylic acid；3,5-dimethylpyrazole-1-carboxylic acid
• 化学式: C₆H₈N₂O₂
• 分子量: 140.142
• InChiKey: WMXDHTDKVGBIBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,5-dimethyl-pyrazole-1-carboxylic acid ethyl ester 在 氢氧化钾 作用下， 生成 3,5-dimethyl-pyrazole-1-carboxylic acid
  参考文献：
  名称：

  Mingoia; Ingraffia, Gazzetta Chimica Italiana, 1934, vol. 64, p. 279,282

  摘要：

  DOI：

文献信息

• Substituted indolinones
  申请人：——

  公开号：US20030092756A1

  公开（公告）日：2003-05-15

  The present invention relates to indolinones substituted in the 6-position of general formula 1 wherein R 1 to R 5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and cyclin/CDK complexes and on the proliferation of endothelial cells and various, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

  本发明涉及一种通式1中6位取代的吲哚酮，其中R1至R5和X的定义如权利要求1中定义的，其异构体和盐，特别是具有有价值的药理特性的生理上可接受的盐，特别是对各种受体酪氨酸激酶和细胞周期蛋白/CDK复合物以及内皮细胞增殖具有抑制作用的物质，含有这些化合物的药物组合物，其用途和制备这些化合物的方法。
• Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions
  申请人：Heckel Armin

  公开号：US20060194813A1

  公开（公告）日：2006-08-31

  The present invention relates to indolinone derivatives substituted in the 6 position of general formula wherein R 1 to R 6 and X are defined as in claim 1 , the tautomers, enantiomers, diastereomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof, which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

  本发明涉及一种在通式中6位取代的吲哚酮衍生物，其中R1至R6和X如权利要求1所定义，其互变异构体、对映异构体、顺反异构体、混合物及其盐，特别是其生理上可接受的盐，具有有价值的药理特性，特别是对各种受体酪氨酸激酶和内皮细胞以及各种肿瘤细胞的增殖具有抑制作用，包含这些化合物的制药组合物，它们的用途和制备过程。
• Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
  申请人：Kley Joerg

  公开号：US20050054710A1

  公开（公告）日：2005-03-10

  The present invention relates to heterocyclically substituted indolinones of general formula wherein R 1 to R 5 and X are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and cyclin/CDK complexes and on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

  本发明涉及一般式为的杂环取代吲哚酮 其中R1至R5和X的定义如权利要求1中所述，其互变异构体、对映异构体、混合物、前药及其盐，特别是具有有价值的药理学特性，特别是对各种受体酪氨酸激酶和环/ CDK复合物以及内皮细胞和各种肿瘤细胞的增殖具有抑制作用的生理上可接受的盐，包含这些化合物的制药组合物，它们的用途和制备它们的过程。
• Substituierte Pyrrole
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0328026A1

  公开（公告）日：1989-08-16

  Pyrrole der allgemeinen Formel worin R¹, R², R³, R⁴, R⁵, R⁶, R⁷, X und Y die in der Beschreibung angegebene Bedeutung haben sind verwendbar bei der Behandlung oder Prophylaxe von inflammatorischen, immunologischen, bronchopulmonären oder cardiovaskulären Krankheiten. Sie werden ausgehend von entsprechend substituierten Furanen oder von auf andere Weise substituierten Pyrrolen hergestellt.

  通式如下的吡咯 其中 R¹、R²、R³、R⁴、R⁵、R⁶、R⁷、X 和 Y 具有说明中给出的含义，可用于治疗或预防炎症、免疫学、支气管肺病或心血管疾病。 它们由适当取代的呋喃或其他取代的吡咯制备而成。
• Organic metal compounds in which compounds for host and compounds for dopant are connected, organic electroluminesence display devices using the compounds and method for preparation of the devices
  申请人：Park Jin Soo

  公开号：US20060237714A1

  公开（公告）日：2006-10-26

  The present embodiments relate to organic metal compounds in which compounds for host and compounds for dopant are connected, organic electroluminescence display devices using the compounds and a method for preparation of the devices. More precisely, the present embodiments relate to organic metal compounds in which compounds for host and compounds for dopant were connected to make energy transmission between host and dopant possible in a molecular level, organic electroluminescence display devices using the same and a preparation method thereof. And, the organic metal compound of the present embodiments has the structure having the connection of the compounds for host and the compounds for dopant, so that its solubility can be remarkably increased owing to the increased molecular weight. Thus, a wet process such as spin coating can be applied for the preparation of the device.

  本实施例涉及有机金属化合物（其中连接了宿主化合物和掺杂剂化合物）、使用该化合物的有机电致发光显示装置以及制备该装置的方法。更确切地说，本实施例涉及有机金属化合物（其中连接了宿主化合物和掺杂剂化合物，使宿主和掺杂剂之间的能量传输在分子水平上成为可能）、使用该化合物的有机电致发光显示器件及其制备方法。而且，本实施例的有机金属化合物具有连接宿主化合物和掺杂剂化合物的结构，因此由于分子量增加，其溶解度可显著提高。因此，可以采用湿法工艺（如旋涂）来制备该装置。