3-methyl-1,3-thiazolidin-3-ium-4-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-methyl-1,3-thiazolidin-3-ium-4-carboxylate
• 化学式: C5H9NO2S
• 分子量: 147.2
• InChiKey: HAWVIMZLOKHWMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  65.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  DL-半胱氨酸盐酸盐 、 聚合甲醛 生成 3-methyl-1,3-thiazolidin-3-ium-4-carboxylate
  参考文献：
  名称：

  ANDO, VATARU;TAKADA, TOSIKADZU;JOKO, TOSIXITO;TAMURA, JOSIXARU

  摘要：

  DOI：

文献信息

• METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS
  申请人：Dong Zheng Xin

  公开号：US20100234564A1

  公开（公告）日：2010-09-16

  The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal N-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a β-(methylamino)-thioester intermediate that spontaneously rearranges to form an amide bond. Furthermore, the invention relates to methods of converting N-methyl-thiazolidine to N-methyl-cysteine (SEQ ID NO: 1) of polypeptides and proteins. The invention also relates to methods of synthesizing peptide-thioester from peptide-acid fluoride.

  本发明涉及用于合成多肽和蛋白质的化学合成方法和中间体，更具体地，涉及用于化学连接含有N-甲基半胱氨酸（SEQ ID NO：1）N-末端的肽片段与具有C-末端硫酸酯的另一个肽片段以生成β-（甲氨基）-硫酸酯中间体的方法和中间体，该中间体会自发重排形成酰胺键。此外，本发明还涉及将N-甲基噻唑啉转化为多肽和蛋白质中的N-甲基半胱氨酸（SEQ ID NO：1）的方法。本发明还涉及从肽酸氟合成肽硫酸酯的方法。
• Methods and intermediates for chemical synthesis of polypeptides and proteins
  申请人：Dong Zheng Xin

  公开号：US08404804B2

  公开（公告）日：2013-03-26

  The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal N-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a β-(methylamino)-thioester intermediate that spontaneously rearranges to form an amide bond. Furthermore, the invention relates to methods of converting N-methyl-thiazolidine to N-methyl-cysteine (SEQ ID NO: 1) of polypeptides and proteins. The invention also relates to methods of synthesizing peptide-thioester from peptide-acid fluoride.

  本发明涉及用于化学合成多肽和蛋白质的方法和中间体，更具体地涉及用于化学连接含有N-甲基半胱氨酸（SEQ ID NO: 1）的肽片段与具有C-末端硫酸酯的另一个肽片段以生成β-（甲基氨基）-硫酯中间体的方法和中间体，该中间体会自发重排形成酰胺键。此外，本发明还涉及将N-甲基噻唑啉转化为多肽和蛋白质中的N-甲基半胱氨酸（SEQ ID NO: 1）的方法。本发明还涉及从肽酸氟合成肽硫酸酯的方法。