Mevinic acid | 84064-38-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: Mevinic acid
• 英文别名: (3R,5R)-7-[(1S,2S,8S,8aR)-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid
• CAS: 84064-38-0
• 化学式: C₂₃H₃₆O₆
• 分子量: 408.5
• InChiKey: BOZILQFLQYBIIY-INTXDZFKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  、 葡萄糖 、 potassium dihydrogenphosphate 、 Mevinic acid 以 GL(10_glycerol—5_lactose) 为溶剂， 反应 96.0h， 生成 普伐他汀
  参考文献：
  名称：

  Strains of Saccharaothrix, process for producing pravastain using the strains and isolation process of (HMG)-CoA reductase

  摘要：

  本发明提供了两株新的Saccharothrix微生物菌株，分别命名为YS-44442和YS-45494，使用这些菌株生产普伐他汀的方法，以及改进的(HMG)-CoA还原酶抑制剂的分离方法。

  公开号：

  US07202062B2
• 作为产物：
  描述：

  、 氨苄西林 、 异丙基-beta-D-硫代半乳糖吡喃糖苷 、 5-氨基乙酰丙酸 、 、 Compactin sodium 、 还原型辅酶II(NADPH)四钠盐 、 普伐他汀 在 NaH2PO4 、 乙二胺四乙酸 、 1,4-dithio-D,L-threitol 作用下， 以 乙腈 、 甘油 为溶剂， 反应 82.68h， 生成 Mevinic acid
  参考文献：
  名称：

  Expression system for actinomycete-origin cytochrome p-450 in escherichia coli

  摘要：

  本发明涉及一种在宿主大肠杆菌中表达细胞色素P-450基因的系统，并提供了含有放线菌类铁蛋白基因、异源于大肠杆菌的铁蛋白基因和铁蛋白还原酶基因的大肠杆菌。因此，本发明有助于促进底物有机化合物的有效单个氧原子插入反应。

  公开号：

  US20060234337A1

文献信息

• Method of purifying pravastatin
  申请人：Keri Vilmos

  公开号：US20050113446A1

  公开（公告）日：2005-05-26

  The present invention provides pure pravastatin compositions and pure compactin compositions, and methods for the preparation thereof.

  本发明提供了纯普伐他汀和纯紧密素的组合物及其制备方法。
• Treatment of type 1 diabetes with PDE5 inhibitors
  申请人：Pfizer Inc

  公开号：US20040186046A1

  公开（公告）日：2004-09-23

  The use of a PDE5 inhibitor without substantial PDE2 inhibiting activity, or a pharmaceutically acceptable salt thereof in the preparation of a medicament for the treatment of Type 1 Diabetes. A method of treating Type 1 Diabetes in an individual suffering from Type 1 Diabetes, which method comprises administering to said individual an effective amount of a PDE5 inhibitor without substantial PDE2 inhibiting activity, or a pharmaceutically acceptable salt thereof.

  使用一种没有显著PDE2抑制活性的PDE5抑制剂或其药学上可接受的盐来制备治疗1型糖尿病的药物。一种治疗1型糖尿病的方法，包括向患有1型糖尿病的个体施用有效量的没有显著PDE2抑制活性的PDE5抑制剂或其药学上可接受的盐。
• METHOD OF PURIFYING PRAVASTATIN
  申请人：Keri Vilmos

  公开号：US20080300305A1

  公开（公告）日：2008-12-04

  The present invention provides pure pravastatin compositions and pure compactin compositions, and methods for the preparation thereof.

  本发明提供纯普伐他汀组合物和纯紧密素组合物，以及其制备方法。
• MEASURING THE DISTANCE BETWEEN DEVICES
  申请人：Wilcox Martin S.

  公开号：US20090171621A1

  公开（公告）日：2009-07-02

  This invention provides compositions and methods for producing low cholesterol poultry eggs using hypocholesterolemic compounds, cholesterol lowering supplements, and feeds therefrom. Preferably, this invention provides microbial statins without methyl group in C6, as shown in formula V, in order to produce low cholesterol poultry eggs. The invention allows producing low cholesterol poultry eggs without concomitant reduction of egg production by providing microbial statins, compactin and pravastatin as well as their derivatives, as cholesterol lowering components. This invention also provides methods for producing low cholesterol poultry eggs without huge increase of production cost since the effective amount of cholesterol lowering composition containing microbial statin costs 1/120-¼ of that of synthetic statin.
• Cholesterol lowering supplement and low cholesterol egg produced by using the same
  申请人：Kim Jeong hak

  公开号：US20090181150A1

  公开（公告）日：2009-07-16

  This invention provides compositions and methods for producing low cholesterol poultry eggs using hypocholesterolemic compounds, cholesterol lowering supplements, and feeds therefrom. Preferably, this invention provides microbial statins without methyl group in C6, as shown in formula V, in order to produce low cholesterol poultry eggs. The invention allows producing low cholesterol poultry eggs without concomitant reduction of egg production by providing microbial statins, compactin and pravastatin as well as their derivatives, as cholesterol lowering components. This invention also provides methods for producing low cholesterol poultry eggs without huge increase of production cost since the effective amount of cholesterol lowering composition containing microbial statin costs 1/20-¼ of that of synthetic statin.