2-Dodecylbenzoic acid | 89360-54-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Dodecylbenzoic acid
• 英文别名: dodecylbenzoic acid
• CAS: 89360-54-3
• 化学式: C₁₉H₃₀O₂
• 分子量: 290.446
• InChiKey: WLPQHPARWSMVFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  21
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Dodecylbenzoic acid 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 2-dodecylbenzoyl chloride
  参考文献：
  名称：

  Thiophenyl Alkanoic acids useful as leukotriene antagonists

  摘要：

  本发明涉及具有苯基和硫代取代基的烷酸化合物，其可用作白三烯拮抗剂，并含有这种化合物的药物组合物。本发明还涉及通过给予上述化合物或组合物的有效量来治疗白三烯在其中是因素的疾病。

  公开号：

  US04874792A1
• 作为产物：
  描述：

  lithium diisopropyl amide 、 正丁基锂 、 、 对甲苯甲酸 、 1-溴十一烷 在 ice 、 水 、 四氢呋喃 、 乙醚 、 乙腈 、 正己烷 作用下， 以 四氢呋喃 为溶剂， 反应 1.08h， 生成 2-Dodecylbenzoic acid
  参考文献：
  名称：

  Ortho-substituted benzaldehydes

  摘要：

  本发明涉及某些2-取代苯甲醛，其是制备某些二酸的有用中间体，该二酸可用作白三烯拮抗剂。

  公开号：

  US05189226A1

文献信息

• Thiophenyl Alkanoic acids useful as leukotriene antagonists
  申请人：Smithkline Beckman Corporation

  公开号：US04874792A1

  公开（公告）日：1989-10-17

  This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

  本发明涉及具有苯基和硫代取代基的烷酸化合物，其可用作白三烯拮抗剂，并含有这种化合物的药物组合物。本发明还涉及通过给予上述化合物或组合物的有效量来治疗白三烯在其中是因素的疾病。
• Leukotriene antagonists
  申请人：SmithKline Beckman Corporation

  公开号：US04820719A1

  公开（公告）日：1989-04-11

  This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

  本发明涉及具有苯基和硫代取代基的烷酸化合物，其作为白三烯拮抗剂使用，并含有这种化合物的药物组合物。本发明还涉及通过给予上述化合物或组合物的有效剂量来治疗白三烯是因素的疾病的方法。
• POLYCARBONATE RESIN COMPOSITION AND PROCESS FOR PRODUCING THE SAME
  申请人：Souma Minoru

  公开号：US20100256270A1

  公开（公告）日：2010-10-07

  There is provided a polycarbonate resin composition containing aluminum oxide nanoparticles and being capable of showing good moldability and retention heat stability and combining high transparency and dimensional stability with excellent mechanical properties. The polycarbonate resin composition is characterized by containing an organic acid and aluminum oxide and in that: the resin composition has a melt mass flow rate of 11 g/10 min or higher as measured according to JIS K 7210 under the conditions of a temperature of 280° C., a nominal load of 2.16 Kg and a nozzle dimension UD of 8/2; and a No.2 dumbbell-shaped specimen according to JIS K 7113 formed by heat-press molding the resin composition into a film of 0.2 mm in thickness and cutting the film has a breaking stress of 8 MPa or higher as measured under the conditions of a temperature of 23° C., a humidity of 50% RH and a tensile rate of 50 min/min. The organic acid is preferably an organic sulfonic acid having a carbon number of 8 or greater, more preferably the one containing an aromatic ring in the molecule.

  提供了一种聚碳酸酯树脂组合物，其中含有氧化铝纳米颗粒，能够展示良好的可成型性和保持热稳定性，并将高透明度和尺寸稳定性与优异的机械性能相结合。该聚碳酸酯树脂组合物的特征在于含有有机酸和氧化铝，并且：根据JIS K 7210的条件，在温度为280℃、名义负荷为2.16千克和喷嘴尺寸UD为8/2的条件下测量，该树脂组合物具有11克/10分钟或更高的熔体质量流动速率；根据JIS K 7113形成的第2号哑铃形试样，通过将树脂组合物热压成厚度为0.2毫米的薄膜并切割薄膜，在温度为23℃、湿度为50% RH和拉伸速率为50 min/min的条件下测量，其断裂应力为8兆帕或更高。有机酸最好是具有8个或更多碳原子的有机磺酸，更好的是分子中含有芳香环的有机磺酸。
• Preparation of salt-free N-acyl taurines
  申请人：GAF CORPORATION

  公开号：EP0002675A1

  公开（公告）日：1979-07-11

  A process for preparing a substantially saltfree N-acyl taurine by reacting 1 mole of a higher molecular weight carboxylic acid chloride with 1 mole of a taurine salt containing at least 1 N-bonded H atom in a lower alkanol initially containing no more than about 15% by weight of water and about 1 mole of an alkali metal hydroxide at elevated temperatures, preferably at reflux, separating the insoluble precipitated alkali metal chloride from the alkanolic reaction medium at a temperature high enough to solubilize the N-acyl taurine reaction product, and cooling the reaction medium low enough to precipitate the desired N-acyl taurine.

  一种制备基本上不含盐的 N-酰基牛磺酸的工艺，其方法是：在最初含有不超过约 15%（重量）水和约 1 摩尔碱金属氢氧化物的低级烷醇中，使 1 摩尔较高分子量的羧酸氯化物与 1 摩尔含有至少 1 个 N 键 H 原子的牛磺酸盐在高温下反应、最好在回流条件下，在足以溶解 N-酰基牛磺酸反应产物的高温下，将不溶解的沉淀碱金属氯化物从烷醇反应介质中分离出来，并将反应介质冷却到足以沉淀出所需的 N-酰基牛磺酸的低温。
• Preparation of water dispersible, modified polyurethanes
  申请人：RHEOX INTERNATIONAL, INC.

  公开号：EP0127950A1

  公开（公告）日：1984-12-12

  A water dispersible, modified polyurethane which resists microbial attack, exhibits superior efficiency in thickening aqueous compositions and imparts improved leveling, is the reaction product of: a) a polyisocyanate; b) from 0.10 to 10.00 moles per mole of polyisocyanate of a polyether polyol; c) from 0.015 to 3.400 moles per mole of polyisocyanate, of a modifying agent having the formula wherein R represents a group containing from 0 to 10 carbon atoms, X is a group containing at least one active hydrogen moiety selected from primary amino, secondary amino, carboxyl and mixturesthereof, Y is a group containing at least one active hydrogen moiety selected from primary amino, secondary amino, carboxyl, hydroxyl, mercapto and mixtures thereof, the sum of (x + y) is an integer greater than 1, and X is at least 1; and d) capping agent which is reactive with the reaction product of (a) the polyisocyanate, (b) the polyether polyol and the (c) modifying agent, and which is present in an amount sufficient to cap the said reaction product.

  一种可在水中分散的改性聚氨酯是下列物质的反应产物，它能抵抗微生物的侵蚀，在增稠水性组合物方面表现出卓越的功效，并能改善流平性： a) 多异氰酸酯 b) 每摩尔多异氰酸酯中含有 0.10 至 10.00 摩尔的聚醚多元醇； c) 每摩尔多异氰酸酯中含 0.015 至 3.400 摩尔的改性剂，其式如下 其中 R 代表含有 0 至 10 个碳原子的基团，X 是含有至少一个选自伯氨基、 仲氨基、羧基及其混合物的活性氢的基团，Y 是含有至少一个选自伯氨基、 仲氨基、羧基、羟基、巯基及其混合物的活性氢的基团，(x+y)之和是大 于 1 的整数，且 X 至少为 1；以及 d) 封端剂，与(a)多异氰酸酯、(b)聚醚多元醇和(c)改性剂的反应产物反应，其含量足以封端所述反应产物。