Butanedioic acid monoammonium salt | 15574-09-1

• 物质功能分类: 无机化工 - 无机盐 - 无机铵盐
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Butanedioic acid monoammonium salt
• 英文别名: azane;butanedioic acid
• CAS: 15574-09-1
• 化学式: C4H12N2O4
• mdl: MFCD00020534
• 分子量: 152.15
• InChiKey: NHJPVZLSLOHJDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  82.3
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险性防范说明：
  P261,P264,P271,P280,P302+P352,P304+P340,P305+P351+P338,P312,P362,P403+P233,P501
• 危险性描述：
  H315,H319,H335

制备方法与用途

用途：适用于有机合成、制药工业以及分析试剂等领域。

反应信息

• 作为反应物：
  描述：

  Butanedioic acid monoammonium salt 以1%的产率得到
  参考文献：
  名称：

  ZHAROV, A. A.;CHISTOTINA, N. P., DOKL. AN CCCP, 306,(1989) N, S. 650-654

  摘要：

  DOI：
• 作为产物：
  描述：

  丁二酸 生成 Butanedioic acid monoammonium salt
  参考文献：
  名称：

  OCHNEVA V. A.; KONOVA N. M.; DYADCHENKO A. I.; POPOVA Z. G.; PANKOVA T. A+, SINTEZ I ISSLED. EHFFEKTIV. XIMIKATOV DLYA POLIMER. MATER. TEZ. DOKL. K 8+

  摘要：

  DOI：

文献信息

• Succinic acid production and purification
  申请人：Michigan State University

  公开号：US06265190B1

  公开（公告）日：2001-07-24

  A highly efficient process for the production and recovery of pure succinic acid from a succinate salt that involves minimal use of additional reagents, and produces virtually no waste by-products, and permits internal recycle of the base and acid values, is provided. The method involves the formation of diammonium succinate, either by using an ammonium ion based material to maintain neutral8 pH in the fermenter or by substituting the ammonium cation for the cation of the succinate salt created in the fermenter. The diammonium succinate can then be reacted with a sulfate ion, such as by combining the diammonium succinate with ammonium bisulfate and/or sulfuric acid at sufficiently low pH to yield succinic acid and ammonium sulfate. The ammonium sulfate is advantageously cracked thermally into ammonia and ammonium bisulfate. The succinic acid can be purified with a methanol dissolution step. Various filtration, reflux and reutilization steps can also be employed.

  提供了一种高效的工艺，用于从琥珀酸盐中生产和回收纯琥珀酸，该工艺最小限度地使用额外试剂，几乎不产生废弃物，允许基础和酸价的内部循环。该方法涉及通过使用以铵离子为基础材料维持发酵罐中的中性pH或通过将铵阳离子替换为在发酵罐中创建的琥珀酸盐的阳离子来形成二铵琥珀酸盐。然后可以将二铵琥珀酸盐与硫酸根离子反应，例如在足够低的pH下将二铵琥珀酸盐与硫酸氢铵和/或硫酸反应，以产生琥珀酸和硫酸铵。硫酸铵可以有利地通过热裂解成氨和硫酸氢铵。琥珀酸可以通过甲醇溶解步骤纯化。还可以采用各种过滤、回流和再利用步骤。
• Method for producing organic acid ammonium solution
  申请人：Isotani Atsushi

  公开号：US20070015264A1

  公开（公告）日：2007-01-18

  Organic acid ammonium solution is produced by the steps of obtaining a fermentation broth containing organic acid magnesium by using an organic acid-producing microorganism in the presence of a magnesium compound, producing organic acid ammonium and a magnesium compound by subjecting the organic acid magnesium contained in the fermentation broth to salt-exchange using an ammonia compound, and separating the produced magnesium compound to obtain organic acid ammonium solution.

  有机酸铵溶液的制备方法包括以下步骤：使用有机酸产生微生物在镁化合物的存在下发酵得到含有有机酸镁的发酵液；通过使用氨化合物对发酵液中含有的有机酸镁进行盐交换反应，得到有机酸铵和镁化合物；分离所得的镁化合物，从而得到有机酸铵溶液。
• METHOD OF MANUFACTURING SUCCINIC ACID AND AMMONIUM SUCCINATE SOLUTIONS
  申请人：Nishi Kiyohiko

  公开号：US20100094051A1

  公开（公告）日：2010-04-15

  The present invention provides a method of manufacturing a highly pure ammonium succinate solution including the steps of (A) producing calcium succinate trihydrate by crystallization fermentation of a microorganism; (B) converting calcium succinate trihydrate to calcium succinate monohydrate by transition crystallization; (C) separating the calcium succinate monohydrate crystals; (D) substituting the calcium salt in the calcium succinate monohydrate with ammonium salt resulting in an ammonium succinate solution; and (E) removing the solid calcium carbonate from the ammonium succinate solution.

  本发明提供了一种制备高纯度丙酸铵溶液的方法，包括以下步骤：(A)通过微生物结晶发酵生产丙酸钙三水合物；(B)通过过渡结晶将丙酸钙三水合物转化为丙酸钙单水合物；(C)分离丙酸钙单水合物晶体；(D)用铵盐替代丙酸钙单水合物中的钙盐，从而得到丙酸铵溶液；以及(E)从丙酸铵溶液中除去固体碳酸钙。
• Method of manufacturing succinic acid and ammonium succinate solutions
  申请人：Ajinomoto Co., Inc.

  公开号：US08034975B2

  公开（公告）日：2011-10-11

  The present invention provides a method of manufacturing a highly pure ammonium succinate solution including the steps of (A) producing calcium succinate trihydrate by crystallization fermentation of a microorganism; (B) converting calcium succinate trihydrate to calcium succinate monohydrate by transition crystallization; (C) separating the calcium succinate monohydrate crystals; (D) substituting the calcium salt in the calcium succinate monohydrate with ammonium salt resulting in an ammonium succinate solution; and (E) removing the solid calcium carbonate from the ammonium succinate solution.

  本发明提供了一种制备高纯度琥珀酸铵溶液的方法，包括以下步骤：(A)通过微生物结晶发酵生产出琥珀酸钙三水合物；(B)通过过渡结晶将琥珀酸钙三水合物转化为琥珀酸钙单水合物；(C)分离出琥珀酸钙单水合物晶体；(D)用铵盐取代琥珀酸钙单水合物中的钙盐，得到琥珀酸铵溶液；(E)从琥珀酸铵溶液中去除固体碳酸钙。
• METHODS FOR PREPARATION OF AMMONIUM SALTS OF C4 DIACIDS BY FERMENTAION AND INTEGRATED METHODS FOR MAKING C4 DERIVATIVES
  申请人：Ma ChiCheng

  公开号：US20140162326A1

  公开（公告）日：2014-06-12

  Methods for forming ammonium salts of C4 diacids in a fermentation process with removal of divalent metal carbonate salts are disclosed. The pH of fermentation broths for production of C4 diacids is controlled by adding alkaline oxygen containing calcium or magnesium compounds, which forms divalent metal salts of the diacids. The divalent metal salts of the diacids are substituted with ammonium by introduction of ammonium salts at elevated temperature and pressure forming soluble ammonium salts thereof. C02 or bicarbonate is simultaneously added to the fennentation media at the elevated temperature and pressure. Reducing the temperature and pressure forms insoluble divalent metal carbonate salts that are separated from the solubilized ammonium diacid salts.

  本发明涉及一种利用发酵过程形成C4二酸铵盐的方法，并去除二价金属碳酸盐盐。通过添加含氧的钙或镁化合物，控制C4二酸的发酵产物的pH值，形成二价金属盐。然后在高温高压下引入铵盐，将二价金属盐替换为铵盐，形成可溶性的铵盐。同时，在高温高压下向发酵培养基中添加C02或碳酸氢盐。降低温度和压力，形成不溶性的二价金属碳酸盐，将其与可溶性的铵二酸盐分离。