(2S)-2-[[(2S)-2-[[2-[(4-羟基苯甲酰基)氨基]乙酰基]氨基]-3-(3H-咪唑-4-基)丙酰]氨基]-4-甲基戊酸 | 77697-23-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (2S)-2-[[(2S)-2-[[2-[(4-羟基苯甲酰基)氨基]乙酰基]氨基]-3-(3H-咪唑-4-基)丙酰]氨基]-4-甲基戊酸
• 英文名称: P-HYDROXYHIPPURYL-HIS-LEU-OH
• 英文别名: (2S)-2-[[(2S)-2-[[2-[(4-hydroxybenzoyl)amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoic acid
• CAS: 77697-23-5
• 化学式: C₂₁H₂₇N₅O₆
• mdl: MFCD00038808
• 分子量: 445.475
• InChiKey: IHVRJTCVMKJNRP-IRXDYDNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  174
• 氢给体数：
  6
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  Z-Gly-His-Leu-OMe 、 氢溴酸 、 溶剂黄146 在 carbobenzoxy 、 乙醚 作用下， 反应 1.0h， 生成 (2S)-2-[[(2S)-2-[[2-[(4-羟基苯甲酰基)氨基]乙酰基]氨基]-3-(3H-咪唑-4-基)丙酰]氨基]-4-甲基戊酸
  参考文献：
  名称：

  Method for determining the activity of the angiotensin-converting enzyme

  摘要：

  测定血管紧张素转换酶活性的方法包括以下步骤：(1)将含有血管紧张素转换酶的液体与由X-海泊鲁-亮氨酰-组氨酸、海泊鲁酶、过氧化物酶、4-氨基安替比林和H.sub.2 O.sub.2组成的试剂混合，(2)用比色法测量步骤(1)中产生的醌亚胺染料的浓度。

  公开号：

  US04292404A1

文献信息

• Inhibitors of angiotensin converting enzyme
  申请人：AJINOMOTO CO. INC

  公开号：US20040014670A1

  公开（公告）日：2004-01-22

  The object of the present invention is to provide a peptide having angiotensin converting enzyme inhibitory activity also improved in the taste, and to provide a method of producing an angiotensin converting enzyme inhibitors comprising at least one of such enzymes. Another object of the present invention is to provide an antihypertensive comprising a peptide having angiotensin converting enzyme inhibitory activity. Thus, the present invention is any of the five peptides represented by the following formula (1) to (5) and the salts thereof, soybean protein hydrolysates containing these peptides and the method of producing these peptides or the salts thereof comprising hydrolyzing soybean proteins with protease D3:(1)Tyr-Val-Val-Phe-Lys; (2)Pro-Asn-Asn-Lys-Pro-Phe-Gln; (3)Asn-Trp-Gly-Pro-Leu-Val; (4)Ile-Pro-Pro-Gly-Val-Pro-Tyr-Trp-Thr; (5)Thr-Pro-Arg-Val-Phe.

  本发明的目的是提供一种具有血管紧张素转换酶抑制活性且味道改善的肽，并提供一种制备至少包含这些酶之一的血管紧张素转换酶抑制剂的方法。本发明的另一个目的是提供一种包含具有血管紧张素转换酶抑制活性的肽的降压剂。因此，本发明是以下公式（1）至（5）和其盐中的任何一种肽，以及含有这些肽的大豆蛋白水解物和制备这些肽或其盐的方法，包括用蛋白酶D3水解大豆蛋白：(1)Tyr-Val-Val-Phe-Lys；（2）Pro-Asn-Asn-Lys-Pro-Phe-Gln；（3）Asn-Trp-Gly-Pro-Leu-Val；（4）Ile-Pro-Pro-Gly-Val-Pro-Tyr-Trp-Thr；（5）Thr-Pro-Arg-Val-Phe。
• ANGIOTENSIN CONVERTING ENZYME INHIBITORS
  申请人：Ajinomoto Co., Inc.

  公开号：EP1352911A1

  公开（公告）日：2003-10-15

  the object of the present invention is to provide a peptide having angiotensin converting enzyme inhibitory activity also improved in the taste, and to provide a method of producing an angiotensin converting enzyme inhibitors comprising at least one of such enzymes. Another object of the present invention is to provide an antihypertensive comprising a peptide having angiotensin converting enzyme inhibitory activity. Thus, the present invention is any of the five peptides represented by the following formula (1) to (5) and the salts thereof, soybean protein hydrolysates containing these peptides and the method of producing these peptides or the salts thereof comprising hydrolyzing soybean proteins with protease D3:(1)Tyr-Val-Val-Phe-Lys; (2)Pro-Asn-Asn-Lys-Pro-Phe-Gln; (3)Asn-Trp-Gly-Pro-Leu-Val; (4)lle-Pro-Pro-Gly-Val-Pro-Tyr-Trp-Thr; (5)Thr-Pro-Arg-Val-Phe.

  本发明的目的是提供一种具有血管紧张素转换酶抑制活性的多肽，其口感也有所改善，并提供一种生产血管紧张素转换酶抑制剂的方法，该抑制剂包含至少一种这样的酶。本发明的另一个目的是提供一种抗高血压药物，其中包含一种具有血管紧张素转换酶抑制活性的多肽。因此，本发明是下式(1)至(5)所代表的五种肽中的任何一种及其盐，含有这些肽的大豆蛋白水解物，以及生产这些肽或其盐的方法，包括用蛋白酶D3水解大豆蛋白：(1)Tyr-Val-Val-Phe-Lys；(2)Pro-Asn-Asn-Lys-Pro-Phe-Gln；(3)Asn-Trp-Gly-Pro-Leu-Val；(4)le-Pro-Pro-Gly-Val-Pro-Tyr-Trp-Thr；(5)Thr-Pro-Arg-Val-Phe。
• LIQUID SEASONING
  申请人：Kao Corporation

  公开号：EP1949798A1

  公开（公告）日：2008-07-30

  The present invention is a liquid seasoning containing the following (A), (B), and (C): (A) 0.4 to 8% by mass of sodium (B) 0.01 to 4% by mass of flavonoid (C) 1 to 10% by mass of ethanol wherein, the flavonoid (B) satisfies the formula (1) and/or has one or more OH groups on the A-ring or B-ring in a molecule and no OH group at the position adjacent to the OH group (ortho position). Y/X+Y=0.05to1 wherein, X and Y represent the following numbers, respectively: X; the number of OH group bonded to benzene rings in a molecule of the flavonoid, Y; the number of OCH3 group bonded to benzene rings in a molecule of the flavonoid.

  本发明是一种液体调味料，含有以下(A)、(B)和(C)： (A) 0.4%至 8%（按质量计）钠 (B) 0.01 至 4%（按质量计）的黄酮类化合物 (C) 1%至 10%（以质量计）乙醇 其中，类黄酮（B）满足式（1）和/或在分子中的 A 环或 B 环上有一个或多个 OH 基团，而在与 OH 基团相邻的位置（正交位置）没有 OH 基团。Y/X+Y=0.05to1 其中，X 和 Y 分别代表以下数字： X：类黄酮分子中与苯环结合的 OH 基团的数目、 Y；类黄酮分子中与苯环结合的 OCH3 基团的数目。
• Liquid seasoning
  申请人：Tsuchiya Shigemi

  公开号：US20060115517A1

  公开（公告）日：2006-06-01

  The present invention provides a liquid seasoning, which brings on a sufficient salty taste although it has a low sodium concentration, and which exhibits for example a pharmacological effect such as an antihypertensive effect at a high level. The present invention relates to a liquid seasoning, which contains the following components (A) to (D): (A) 3.55% or less by weight of sodium; (B) 0.5% to 4.2% by weight of potassium; (C) more than 2% by weight of an acidic amino acid and/or more than 1% by weight of a basic amino acid; and (D) 0.05% to 10% by weight of a food material having an antihypertensive effect.

  本发明提供了一种液体调味料，虽然钠的浓度较低，但却能带来足够的咸味，并且在高浓度下具有例如降血压等药理作用。本发明涉及一种液体调味料，它含有以下成分(A)至(D)：(A) 3.55%或更少（按重量计）的钠；(B) 0.5%至 4.2%（按重量计）的钾；(C) 2%以上（按重量计）的酸性氨基酸和/或 1%以上（按重量计）的碱性氨基酸；以及(D) 0.05%至 10%（按重量计）的具有降压作用的食品材料。
• RADIOIMAGING MOIETIES COUPLED TO PEPTIDASE-BINDING MOIETIES FOR IMAGING TISSUES AND ORGANS THAT EXPRESS PEPTIDASES
  申请人：Molecular Insight Pharmaceuticals, Inc.

  公开号：EP2061518A2

  公开（公告）日：2009-05-27