6-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoic acid ethyl ester | 57079-07-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoic acid ethyl ester
• 英文别名: N-Maleoyl-6-NH2hexanoic acid,ET ester；ethyl 6-(2,5-dioxopyrrol-1-yl)hexanoate
• CAS: 57079-07-9
• 化学式: C₁₂H₁₇NO₄
• 分子量: 239.271
• InChiKey: YNNQPIGEQVPNCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-马来酰亚胺基己酸 、 乙醇 在 对甲苯磺酸 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 12.0h， 以56%的产率得到6-(2,5-Dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoic acid ethyl ester
  参考文献：
  名称：

  [EN] METHODS OF IDENTIFYING CROSSLINKING MOLECULES FOR POLYMERS
  [FR] PROCÉDÉS D'IDENTIFICATION DE MOLÉCULES DE RÉTICULATION POUR POLYMÈRES

  摘要：

  揭示了用于筛选分子或基团以确定其交联能力的方法。将芳香碳酸酯、芳香酯或脂肪酯基团连接到分子上，以模拟聚合物的存在。辐照修改后的分子的溶液，并测量一阶动力学速率常数。如果速率常数足够高或分子的阈值量被消耗，就使用该分子/基团合成聚合物，作为端基或共聚单体。对聚合物进行辐照，并确定交联密度的增加和凝胶形成百分比。如果这些参数足够高，则表明该分子/基团适合作为交联剂，特别是对于聚碳酸酯。或者，该分子/基团可以仅通过其一阶动力学速率常数被确定为合适。

  公开号：

  WO2015073847A1

文献信息

• [EN] CARBON MONOXIDE RELEASING NORBORNENONE COMPOUNDS<br/>[FR] COMPOSÉS DE NORBORNÉNONE LIBÉRANT DU MONOXYDE DE CARBONE
  申请人：SAMMUT IVAN ANDREW

  公开号：WO2017095237A1

  公开（公告）日：2017-06-08

  The present invention provides organic compounds which are capable of releasing carbon monoxide under physiological conditions or pH trigger, and to the use of such compounds for conditioning a cell, tissue or organ, for example, to protect against ischaemic injury during a transplant event.

  本发明提供了在生理条件或pH触发下能够释放一氧化碳的有机化合物，以及将这种化合物用于调节细胞、组织或器官，例如，在移植事件中保护免受缺血性损伤的使用方法。
• [EN] COMPOSITIONS AND METHODS OF DELIVERY OF DEUBIQUITINASE INHIBITORS<br/>[FR] COMPOSITIONS ET MÉTHODES D'ADMINISTRATION D'INHIBITEURS DE DÉUBIQUITINASE
  申请人：PHARMAKEA INC

  公开号：WO2015183987A1

  公开（公告）日：2015-12-03

  Described herein are compositions comprising deubiquitinase inhibitors in combination with albumin, methods of making such compositions, and methods of using such compositions in the treatment of conditions, diseases, or disorders that would benefit from inhibition of deubiquitinase activity.

  本文描述了含有去泛素化酶抑制剂与白蛋白组合的组合物，制备这种组合物的方法，以及利用这种组合物治疗需要抑制去泛素化酶活性的病症、疾病或紊乱的方法。
• Process for producing polymerizable polybranched polyester
  申请人：Hayakawa Hitoshi

  公开号：US20060047140A1

  公开（公告）日：2006-03-02

  The present invention allows the production of a polymerizable hyperbranched polyester by introducing polymerizable unsaturated double bonds into the molecular terminals of a hyperbranched polyester polyol (A), which is obtained by condensation polymerization a polyhydroxy monocarboxylic acid in which there are at least two hydroxyl groups, the carbon atom adjacent to the carboxy group is saturated carbon atom, and the hydrogen atoms on said carbon atom are all substituted, by reacting the hyperbranched polyester polyol (A) and an alkyl ester of a carboxylic acid having a polymerizable unsaturated double bond (B) by a transesterification in the presence of at least one type of transesterification catalyst (C) selected from the group consisting of a dialkyl tin oxide and a stanoxane, without causing side reactions such as nucleophilic addition reactions of terminal hydroxyl groups to polymerizable unsaturated double bonds of the hyperbranched polyester polyol (A), or thermal polymerization of the polymerizable unsaturated double bonds. The polymerizable hyperbranched polyester can be produced at high efficiency using a transesterification that uses as an alkyl ester of a carboxylic acid having a polymerizable unsaturated double bond (B), which is easily obtained as an industrial raw material, and without altering the original backbone structure of the molecular chains of the hyperbranched polyester polyol (A) by hydrolysis and so forth.

  本发明通过在超支化聚酯多元醇（A）的分子端引入可聚合不饱和双键，从而允许生产可聚合的超支化聚酯。超支化聚酯多元醇（A）是通过缩聚至少含有两个羟基的聚羟基一元羧酸（羧基相邻的碳原子是饱和碳原子，该碳原子上的氢原子均被取代）而获得的。在至少一种转酯化催化剂（C）的存在下，通过将超支化聚酯多元醇（A）和具有可聚合不饱和双键的羧酸烷基酯（B）进行酯交换反应，而不引起末端羟基对超支化聚酯多元醇（A）的可聚合不饱和双键的亲核加成反应或热聚合反应等副反应，就可以高效地生产可聚合的超支化聚酯。使用作为工业原料易于获得的具有可聚合不饱和双键的羧酸烷基酯（B）进行酯交换反应，无需通过水解等改变超支化聚酯多元醇（A）的分子链的原始骨架结构。
• Compounds Having A Diphenyl Oxide Backbone and Maleimide Functional Group
  申请人：Musa Osama M.

  公开号：US20100311207A1

  公开（公告）日：2010-12-09

  A compound having a diphenyl oxide backbone, and pendant from the backbone at least one hydrocarbon chain, the hydrocarbon chain containing an ester functionality and being terminated with a maleimide functional group is prepared from the reaction of diphenyl oxide, formaldehyde or paraformaldehyde, and a compound containing both carboxylic acid and maleimide functionality. Exemplary compounds include: in which m and n are independently an integer from 1 to 100, provided that n is greater than m.

  一种具有二苯氧基骨架的化合物，从骨架上悬挂至少一条含有酯基官能团的烃基链，该烃基链以马来酰亲和基团为终止，可以通过二苯氧基、甲醛或多聚甲醛以及含有羧酸和马来酰官能团的化合物的反应制备。示例化合物包括：其中m和n分别是1至100的整数，但n大于m。
• PROCESS FOR PRODUCING POLYMERIZABLE POLYBRANCHED POLYESTER
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP1582548A1

  公开（公告）日：2005-10-05

  The present invention allows the production of a polymerizable hyperbranched polyester by introducing polymerizable unsaturated double bonds into the molecular terminals of a hyperbranched polyester polyol (A), which is obtained by condensation polymerization a polyhydroxy monocarboxylic acid in which there are at least two hydroxyl groups, the carbon atom adjacent to the carboxy group is saturated carbon atom, and the hydrogen atoms on said carbon atom are all substituted, by reacting the hyperbranched polyester polyol (A) and an alkyl ester of a carboxylic acid having a polymerizable unsaturated double bond (B) by a transesterification in the presence of at least one type of transesterification catalyst (C) selected from the group consisting of a dialkyl tin oxide and a stanoxane, without causing side reactions such as nucleophilic addition reactions of terminal hydroxyl groups to polymerizable unsaturated double bonds of the hyperbranched polyester polyol (A), or thermal polymerization of the polymerizable unsaturated double bonds. The polymerizable hyperbranched polyester can be produced at high efficiency using a transesterification that uses as an alkyl ester of a carboxylic acid having a polymerizable unsaturated double bond (B), which is easily obtained as an industrial raw material, and without altering the original backbone structure of the molecular chains of the hyperbranched polyester polyol (A) by hydrolysis and so forth.

  本发明通过在超支化聚酯多元醇（A）的分子末端引入可聚合的不饱和双键来生产可聚合的超支化聚酯，超支化聚酯多元醇（A）是通过缩合聚合多羟基一羧酸得到的，其中至少有两个羟基，与羧基相邻的碳原子是饱和碳原子，并且所述碳原子上的氢原子全部被取代、将超支化聚酯多元醇（A）和具有可聚合不饱和双键的羧酸烷基酯（B）在至少一种酯交换催化剂（C）（选自二烷基氧化锡和链烷氧基）的存在下进行酯交换反应、不引起副反应，如端羟基与超支化聚酯多元醇（A）的可聚合不饱和双键的亲核加成反应，或可聚合不饱和双键的热聚合反应。使用具有可聚合不饱和双键（B）的羧酸烷基酯进行酯交换反应，可高效生产可聚合超支化聚酯，该烷基酯可作为工业原料轻松获得，且不会通过水解等方式改变超支化聚酯多元醇（A）分子链的原始骨架结构。