1-(6-methoxy-1H-benzo[d]imidazol-1-yl)-2-methyl-2-propanol | 1421683-57-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(6-methoxy-1H-benzo[d]imidazol-1-yl)-2-methyl-2-propanol
• 英文别名: 1-(6-Methoxybenzimidazol-1-yl)-2-methylpropan-2-ol；1-(6-methoxybenzimidazol-1-yl)-2-methylpropan-2-ol
• CAS: 1421683-57-9
• 化学式: C₁₂H₁₆N₂O₂
• 分子量: 220.271
• InChiKey: HZVQXXVPDCYYGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  47.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(6-methoxy-1H-benzo[d]imidazol-1-yl)-2-methyl-2-propanol 在 二叔丁基过氧化物 、 copper(l) chloride 作用下， 以 甲苯 为溶剂， 反应 12.0h， 以70%的产率得到6-methoxy-2,2-dimethyl-2,3-dihydrobenzo[4,5]imidazo[2,1-b]oxazole
  参考文献：
  名称：

  Copper-Catalyzed C–H Alkoxylation of Azoles

  摘要：

  We achieved copper-catalyzed intramolecular and intermolecular alkoxylation of azoles. This reaction is a rare example of transition-metal-catalyzed C-H alkoxylation of heteroaromatic compounds. In addition, the alkoxylation reaction proceeded well even In gram scale. In most intermolecular alkoxylations, the use of an excess amount of alcohols (in some cases, alcohols are used as a solvent) is indispensable to efficiently promote the alkoxylation reaction, but this alkoxylation reaction proceeded using only 1 equiv of alcohols.

  DOI：

  10.1021/ol303533z
• 作为产物：
  描述：

  3-氟-4-硝基苯甲醚 在 palladium 10% on activated carbon 、 氢气 、 对甲苯磺酸 、 N,N-二异丙基乙胺 作用下， 以 乙醇 、 甲苯 、 乙腈 为溶剂， 生成 1-(6-methoxy-1H-benzo[d]imidazol-1-yl)-2-methyl-2-propanol
  参考文献：
  名称：

  Copper-Catalyzed C–H Alkoxylation of Azoles

  摘要：

  We achieved copper-catalyzed intramolecular and intermolecular alkoxylation of azoles. This reaction is a rare example of transition-metal-catalyzed C-H alkoxylation of heteroaromatic compounds. In addition, the alkoxylation reaction proceeded well even In gram scale. In most intermolecular alkoxylations, the use of an excess amount of alcohols (in some cases, alcohols are used as a solvent) is indispensable to efficiently promote the alkoxylation reaction, but this alkoxylation reaction proceeded using only 1 equiv of alcohols.

  DOI：

  10.1021/ol303533z

文献信息

• NOVEL BENZIMIDAZOLE COMPOUND AND MEDICAL USE THEREOF
  申请人：Sumitomo Dainippon Pharma Co., Ltd.

  公开号：US20170107211A1

  公开（公告）日：2017-04-20

  The present invention provides a medicament for treating a disease involving Nav 1.7 such as neuropathic pain, nociceptive pain, inflammatory pain, small-fiber neuropathy, erythromelalgia, paroxysmal extreme pain disorder, dysuria, and multiple sclerosis, which comprises a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R 1a , R 1b , R 1c and R 1d are hydrogen, halogen, cyano, C 1-4 alkyl, C 1-4 alkoxy, or the like, provided that at least one of R 1a , R 1b , R 1c and R 1d is C 6-10 aryl, C 6-10 aryloxy, or the like, R 2 and R 3 are hydrogen, C 1-6 alkyl, C 3-10 cycloalkyl, or the like, R 4 is hydrogen, C 1-6 alkyl, C 3-7 cycloalkyl, or the like, m is 1, 2 or 3, L is CR 7 R 8 , and R 7 and R 8 are hydrogen, hydroxyl, C 1-4 alkyl, C 1-4 alkoxy, or the like.

  本发明提供了一种治疗涉及Nav 1.7的疾病的药物，如神经病性疼痛、伤害性疼痛、炎症性疼痛、小纤维神经病、红色痛症、阵发性极端疼痛障碍、排尿困难和多发性硬化症的药物，其包括化合物的结构式(I)或其药用盐，其中R1a、R1b、R1c和R1d为氢、卤素、氰基、C1-4烷基、C1-4甲氧基等，至少其中一个为C6-10芳基、C6-10芳氧基等，R2和R3为氢、C1-6烷基、C3-10环烷基等，R4为氢、C1-6烷基、C3-7环烷基等，m为1、2或3，L为CR7R8，R7和R8为氢、羟基、C1-4烷基、C1-4甲氧基等。
• US9688670B2
  申请人：——

  公开号：US9688670B2

  公开（公告）日：2017-06-27
• Copper-Catalyzed C–H Alkoxylation of Azoles
  作者：Noriaki Takemura、Yoichiro Kuninobu、Motomu Kanai

  DOI：10.1021/ol303533z

  日期：2013.2.15

  We achieved copper-catalyzed intramolecular and intermolecular alkoxylation of azoles. This reaction is a rare example of transition-metal-catalyzed C-H alkoxylation of heteroaromatic compounds. In addition, the alkoxylation reaction proceeded well even In gram scale. In most intermolecular alkoxylations, the use of an excess amount of alcohols (in some cases, alcohols are used as a solvent) is indispensable to efficiently promote the alkoxylation reaction, but this alkoxylation reaction proceeded using only 1 equiv of alcohols.