6-(4-methoxy-phenyl)-4-p-tolyl-3,4-dihydro-1H-pyrimidine-2-thione | 71834-48-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 6-(4-methoxy-phenyl)-4-p-tolyl-3,4-dihydro-1H-pyrimidine-2-thione
• 英文别名: 6-(4-methoxyphenyl)-4-(4-methylphenyl)-3,4-dihydro-1H-pyrimidine-2-thione
• CAS: 71834-48-5
• 化学式: C₁₈H₁₈N₂OS
• 分子量: 310.42
• InChiKey: KZHKXNKQNWRJLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  65.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-(4-methoxy-phenyl)-4-p-tolyl-3,4-dihydro-1H-pyrimidine-2-thione 、 乙酸酐 以68%的产率得到
  参考文献：
  名称：

  AL-HAJJAR F. H.; AL-FARKH Y. A.; HAMOUD H. S., CAN. J. CHEM., 1979, 57, NO 20, 2734-2742

  摘要：

  DOI：
• 作为产物：
  描述：

  1-acetyl-6-(4-methoxy-phenyl)-4-p-tolyl-3,4-dihydro-1H-pyrimidine-2-thione 、 sodium ethanolate 生成 6-(4-methoxy-phenyl)-4-p-tolyl-3,4-dihydro-1H-pyrimidine-2-thione
  参考文献：
  名称：

  AL-HAJJAR F. H.; AL-FARKH Y. A.; HAMOUD H. S., CAN. J. CHEM., 1979, 57, NO 20, 2734-2742

  摘要：

  DOI：

文献信息

• Phucho; Nongpiur; Nongrum, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010, vol. 49, # 3, p. 346 - 350
  作者：Phucho、Nongpiur、Nongrum、Nongkhlaw

  DOI：——

  日期：——
• [EN] 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE DERIVATIVES<br/>[FR] DERIVES DE 2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE
  申请人：ONO PHARMACEUTICAL CO

  公开号：WO2002066443A2

  公开（公告）日：2002-08-29

  The present invention is related to: (1) neutral sphingomyelinase inhibitors containing 2-thioxo 1,2,3,4-tetrahydropyrimidine derivatives of the formula (I): wherein all of the symbols have the same meanings as described hereinbefore, or a non-toxic salt thereof, a hydrate thereof, or a prodrug thereof as active ingredient, (2) novel 2-thioxo-1,2,3,4-tetrahydropyrimidine derivatives of the formula (I): wherein all of the symbols have the same meanings as described hereinbefore, or a non-toxic salt thereof, a hydrate thereof, or a prodrug thereof, (3) some novel specific compounds, and (4) process for the preparation of the compounds of the formula (Ia), or a prodrug thereof. The compounds of the present invention of the formulae (I) and (Ia) are neutral sphingomyelinase inhibitors and therefore are useful for the treatment and/or prevention of arteriosclerosis, cerebral ischemia, cardiac ischemia, lung injury, renal injury, GVHD (graft versus host diseases), transplant rejection, HIV, etc.
• AL-HAJJAR F. H.; AL-FARKH Y. A.; HAMOUD H. S., CAN. J. CHEM., 1979, 57, NO 20, 2734-2742
  作者：AL-HAJJAR F. H.、 AL-FARKH Y. A.、 HAMOUD H. S.

  DOI：——

  日期：——