(2R)-1-[(14R,15S,22S)-14,15-dihydroxy-22-methyloctacosanoyl]piperidine-2-carboxylic acid | 738607-82-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-1-[(14R,15S,22S)-14,15-dihydroxy-22-methyloctacosanoyl]piperidine-2-carboxylic acid
• CAS: 738607-82-4
• 化学式: C₃₅H₆₇NO₅
• 分子量: 581.921
• InChiKey: BHOMGVFAINHXCG-FWGCVNADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.2
• 重原子数：
  41
• 可旋转键数：
  27
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  98.1
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2R)-1-[(14R,15S,22S)-14,15-dihydroxy-22-methyloctacosanoyl]piperidine-2-carboxylic acid 在 sodium periodate 、 jones reagent 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Penasulfate A, a New α-Glucosidase Inhibitor from a Marine Sponge Penares sp.

  摘要：

  A new (alpha-glucosidase inhibitor, penasulfate A, has been isolated from a marine sponge Penares sp.(1) Its structure was elucidated by spectral and chemical methods to be a scalemic mixture of methyl pipecolates acylated with a novel sulfated fatty acid.

  DOI：

  10.1021/np049939e
• 作为产物：
  描述：

  disodium penasulfate A 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 1.0h， 生成 (2R)-1-[(14R,15S,22S)-14,15-dihydroxy-22-methyloctacosanoyl]piperidine-2-carboxylic acid
  参考文献：
  名称：

  Penasulfate A, a New α-Glucosidase Inhibitor from a Marine Sponge Penares sp.

  摘要：

  A new (alpha-glucosidase inhibitor, penasulfate A, has been isolated from a marine sponge Penares sp.(1) Its structure was elucidated by spectral and chemical methods to be a scalemic mixture of methyl pipecolates acylated with a novel sulfated fatty acid.

  DOI：

  10.1021/np049939e

文献信息

• Penasulfate A, a New α-Glucosidase Inhibitor from a Marine Sponge<i> Penares </i>sp.
  作者：Yoichi Nakao、Takashi Maki、Shigeki Matsunaga、Rob W. M. van Soest、Nobuhiro Fusetani*

  DOI：10.1021/np049939e

  日期：2004.8.1

  A new (alpha-glucosidase inhibitor, penasulfate A, has been isolated from a marine sponge Penares sp.(1) Its structure was elucidated by spectral and chemical methods to be a scalemic mixture of methyl pipecolates acylated with a novel sulfated fatty acid.