4-amino-benzoic acid-(2-hydroxy-ethyl ester) | 26495-98-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-amino-benzoic acid-(2-hydroxy-ethyl ester)
• 英文别名: 4-Amino-benzoesaeure-(2-hydroxy-aethylester)；1-(4-Amino-benzoyloxy)-aethanol-(2)；Aethylenglykol-mono-(4-amino-benzoat)；4-Amino-benzoesaeure-(β-oxy-aethylester)；(2-Hydroxyethyl) 4-aminobenzoate；2-hydroxyethyl 4-aminobenzoate
• CAS: 26495-98-7
• 化学式: C₉H₁₁NO₃
• 分子量: 181.191
• InChiKey: JVLRDGKWQRUKMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-hydroxyethyl 4-nitrobenzoate 在 氢气 作用下， 25.0 ℃ 、500.01 kPa 条件下， 以86 %的产率得到4-amino-benzoic acid-(2-hydroxy-ethyl ester)
  参考文献：
  名称：

  Ionic Liquid Immobilized Pd Nanocatalysts for Chemoselective Reduction of Aliphatic/Aromatic Nitro Compounds

  摘要：

  摘要 在这项工作中，我们成功合成了四种离子液体介导的 Pd 纳米催化剂，并利用透射电子显微镜 (TEM)、X 射线衍射分析 (XRD)、X 射线衍射分析 (XRD) 透射电子显微镜 (TEM)、X 射线衍射分析 (XRD)、X 射线光电子能谱 (XPS) 光谱（XPS）和原子吸收光谱（AAS）分析。分散良好且细小的 在 ILPdNPs-4 催化体系中记录到了分散良好且细小的钯纳米颗粒。我们利用这种催化体系 还原了一系列带有硝基的脂肪族和芳香族化合物，并开发出了多种具有生物活性的胺分子。 胺分子。此外，我们还还原了硝基内酯。 硝基内酯被认为是合成肾素抑制剂阿利吉仑（Tekturna®, et al. (Tekturna®，在全球被称为 Rasilez®）的重要起始原料之一。我们还完成了催化剂稳定性测试，并回收了 ILPdNPs-4 催化系统进行了多达八次运行。在回收过程中，没有发现金属浸出、钯黑形成和结块的迹象。 在循环运行过程中，没有记录到金属浸出、钯黑形成和结块的迹象。

  DOI：

  10.2174/1570178620666230622152510

文献信息

• Copper nanoparticles (CuNPs) catalyzed chemoselective reduction of nitroarenes in aqueous medium
  作者：Randhir Rai、Dillip Kumar Chand

  DOI：10.1007/s12039-021-01940-3

  日期：2021.9

  established, under appropriate reaction conditions, using rice (Oryza sativa) as an economic source of reducing as well as a stabilizing agent. Optical and microscopic techniques are employed for the characterization of the synthesized CuNPs and the sizes of the particles were found to be in the range of 8 ± 2 nm. The nanoparticles are used as a catalyst for chemoselective reduction of aromatic nitro compounds

  摘要 建立了从CuSO 4 ·5H 2 O实际合成CuNPs 的程序，在适当的反应条件下，使用水稻（Oryza sativa）作为还原剂和稳定剂的经济来源。光学和显微技术用于表征合成的 CuNPs，发现颗粒的尺寸在 8 ± 2 nm 的范围内。纳米颗粒用作催化剂，用于在环境条件下将芳香族硝基化合物化学选择性还原为相应的胺，水作为反应介质。 图形摘要 CuNPs 是使用水解大米合成的，并用作催化剂将硝基芳烃化学选择性还原为其相应的胺在水中。
• Drug evolution: drug design at hot spots
  申请人：Konishi Yasuo

  公开号：US20060110743A1

  公开（公告）日：2006-05-25

  A new method of designing and generating compounds having an increased probability of being drugs, drug candidates, or biologically active compounds, in particular having a therapeutic utility, is disclosed. The method consists of identifying a group of bioactive compounds, preferably of diverse therapeutic uses or biological activities and built on a common building block. In this group of compounds, side chains modifying the building block are identified and used to generate a second set of compounds according to the proposed methods of hybridization”, “single substitution” or “incorporation of frequently used side chains”. If the compounds in the second set built on the same building block contain an unusually large number of drugs, preferably with diverse therapeutic uses or biological activities, they constitute a “hot spot”. A focused combinatorial library of the “hot spot” is then generated, preferably by methods of combinatorial chemistry, and compounds of this library are screened for a variety of therapeutic uses or biological activities. The method generates drugs, drug candidates, or biologically active compounds with a high probability, without requiring any prior knowledge of biological targets.

  本文揭示了一种设计和生成化合物的新方法，这些化合物具有成为药物、药物候选物或生物活性化合物的概率增加，特别是具有治疗效用。该方法包括识别一组生物活性化合物，最好是具有不同治疗用途或生物活性，并建立在共同的基础上。在这组化合物中，识别修改基础结构的侧链，并使用“杂交”、“单一替换”或“纳入常用侧链”的建议方法生成第二组化合物。如果第二组化合物建立在相同的基础结构上，包含异常数量的药物，最好是具有不同治疗用途或生物活性，它们构成一个“热点”。然后通过组合化学的方法生成一个专注的组合式库，其中包括“热点”的化合物，并对该库中的化合物进行各种治疗用途或生物活性的筛选。该方法生成的药物、药物候选物或生物活性化合物具有高概率，无需任何先前的生物靶标知识。
• Polyimide foams and their preparation
  申请人：ETHYL CORPORATION

  公开号：EP0340028A2

  公开（公告）日：1989-11-02

  Polyimide foams having enhanced compression fatigue life and softness for use in the manufacture of seat cushions and methods for the production of such foams and precursors therefor. These foams are produced from polyimides prepared by reaction of an organic tetracarboxylic acid or derivative thereof, preferably an ester with (a) 1 to 50 mol percent of a diester of (i) a primary amino-substituted aromatic carboxylic acid, and (ii) a polymethylene glycol, and (b) at least one aromatic or heterocyclic primary diamine. Foams can be produced having (a) a fatigue life as deter­mined by ASTM test procedure D 3574-81 using foam speci­mens from three to five inches in thickness (7.6 to 12.7 cm) of at least 15,000 cycles, or (b) an indentation force deflection as determined by ASTM test procedure D3574-81 on foam speci­mens of one-inch thickness of less than 40 pounds of force (178N) at 25% deflection and less than 180 pounds of force (801N) at 65% deflection, or both of (a) and (b).

  聚酰亚胺泡沫塑料具有更长的压缩疲劳寿命和更柔软的特性，可用于制造座垫和生产这种泡沫塑料及其前体的方法。这些泡沫是由有机四羧酸或其衍生物（最好是酯类）与(a)1-50 摩尔%的(i)伯氨基取代芳香族羧酸和(ii)聚亚甲基二醇的二酯，以及(b)至少一种芳香族或杂环族伯二胺反应制备的聚酰亚胺生产的。可生产出具有以下特性的泡沫：(a) 根据 ASTM 试验程序 D 3574-81 确定的疲劳寿命，使用厚度为 3 至 5 英寸（7.6 至 12.7 厘米）的泡沫试样，经 ASTM 试验程序 D3574-81 测定，疲劳寿命至少为 15,000 周；或 (b) 经 ASTM 试验程序 D3574-81 测定，一英寸厚的泡沫试样在挠度为 25% 时的压痕力挠度小于 40 磅力（178N），在挠度为 65% 时的压痕力挠度小于 180 磅力（801N）；或 (a) 和 (b) 两项均达到。
• Polyimide foams and their production
  申请人：ETHYL CORPORATION

  公开号：EP0343999A1

  公开（公告）日：1989-11-29

  Flexible polyimide foams having enhanced compression charateristics and softness for use in the manufacture of seat cushions may be produced from novel polyimides prepared by reaction of at least one aromatic and/or heterocyclic primary diamine with a mixture of at least two organic tetracarboxylic acids or derivatives thereof, at least one of which is from 1 to 40 mol percent of a 2-(vicinal-di-carboxycyclohexenyl)succinic acid or derivative thereof and a second of which is an aromatic tetracarboxylic acid or derivative thereof.

  柔性聚酰亚胺泡沫具有增强的压缩特性和柔软性，可用于制造座垫，其原料是新型聚酰亚胺，制备方法是将至少一种芳香族和/或杂环族伯二胺与至少两种有机四羧酸或其衍生物的混合物反应，其中至少一种是 1 至 40 摩尔百分率的 2-(沧醛-二羧基环己烯)琥珀酸或其衍生物，第二种是芳香族四羧酸或其衍生物。
• Production of foamed polymer structures
  申请人：Imi-Tech Corporation

  公开号：EP0348722A1

  公开（公告）日：1990-01-03

  Described are ways of improving the yields of specification grade polyimide foam on a consistent basis from one run to the next, by use of improved microwave-­based foaming processes. In one such process, the microwave radiation is directd upon the top, sides and ends of the body of polyimide precursor and of the foam structure as it is developing, but the extent to which such radiation impinges upwardly into the bottom of said body and said foam structure is curtailed, preferably by means of a metallic shield located below the precursor and developing foam structure. Mechanisms by which the shields function to provide the improvements of the process are discussed, and methods based thereon are set forth.

  所述方法是通过使用改进的微波发泡工艺，提高规格级聚酰亚胺泡沫塑料的产量。在其中一种工艺中，微波辐射直接照射到聚酰亚胺前驱体和泡沫结构的顶部、侧面和末端，但这种辐射向上照射到前驱体底部和泡沫结构的程度受到限制，最好是通过位于前驱体和泡沫结构下方的金属屏蔽。本文讨论了防护罩在改进工艺方面的作用机制，并阐述了基于此的方法。