ethyl 4-(oxiran-2-yl)benzoate | 905955-68-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 4-(oxiran-2-yl)benzoate
• CAS: 905955-68-2
• 化学式: C₁₁H₁₂O₃
• 分子量: 192.214
• InChiKey: NFTQEQRAKJRPEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 4-(oxiran-2-yl)benzoate 在 四碘化二磷 、 四乙基溴化铵 、 水 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 以86%的产率得到ethyl 4-(1-hydroxyethyl)benzoate
  参考文献：
  名称：

  Novel Iodine Reagent System for Regioselective Cleavage of Epoxides to Alcohols

  摘要：

  Epoxides are converted regioselectively to corresponding higher substituted alcohols with greater yields using diphosphorus tetraiodide (P2I4) as a reducing agent and a catalytic amount of tetraethylammonium bromide at room temperature.

  DOI：

  10.1080/00397910903219492
• 作为产物：
  描述：

  4-乙烯基-苯甲酸乙基酯 在 吡啶 、 (5,10,15,20-tetramesitylporphyrinato)manganese(III) chloride 、 水 、 tert-butylammonium hexafluorophosphate(V) 作用下， 以 乙腈 为溶剂， 以54 %的产率得到ethyl 4-(oxiran-2-yl)benzoate
  参考文献：
  名称：

  使用水作为氧源，具有高法拉第效率的烯烃电化学环氧化

  摘要：

  环氧化物是重要的合成中间体，因为它们很容易开环产生各种具有有用官能团的产物。在这项研究中，我们公开了一种非卤化物介导的烯烃电化学环氧化反应，以水作为氧源形成环氧化物。这种由 (TMP)MnCl（TMP = 四均卟啉）催化的方法表现出卓越的效率，能够以优异的法拉第效率（高达 89%）实现芳香族和脂肪族烯烃的环氧化。初步机理研究表明，单电子氧化产生的 Mn V2O物种是环氧化反应的关键中间体。

  DOI：

  10.1039/d3gc05126a

文献信息

• One-Pot System for Reduction of Epoxides Using NaBH₄, PdCl₂ Catalyst, and Moist Alumina
  作者：Shigetaka Yakabe

  DOI：10.1080/00397910903079607

  日期：2010.4.12

  Reduction of epoxides with sodium borohydride, a catalytic amount of palladium(II) chloride, and chromatographic neutral alumina preloaded with a small amount of water (moist alumina) in hexane gave alcohols in good to excellent yields and good selectivity of the desired products under mild conditions. The reaction system was operationally simple and environmentally friendly. The alumina can be recovered

  用硼氢化钠、催化量的氯化钯 (II) 和色谱中性氧化铝在己烷中预加载少量水（湿氧化铝）还原环氧化物，在温和的条件下，醇的收率良好至极好，所需产物具有良好的选择性。使适应。该反应系统操作简单且环保。氧化铝可以简单地回收并重复使用多次，无需任何处理，具有良好的活性。
• COMPOUNDS AND METHODS FOR TREATMENT OF HYPERTENSION
  申请人：Medivation Technologies, Inc.

  公开号：US20150266884A1

  公开（公告）日：2015-09-24

  Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor α 2B antagonists. The compounds may also bind to and antagonize adrenergic receptor α 1B . The compounds may find use in therapy, e.g., to (i) reduce blood pressure and/or (ii) promote renal blood flow and/or (iii) decrease or inhibit sodium reabsorption. The compounds may also be used to treat diseases or conditions that are, or are expected to be, responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular and renal disorders is particularly described.

  氢化吡啶并[4,3-b]吲哚，吡啶[3,4-b]吲哚和氮杂七元[4,5-b]吲哚被描述。这些化合物可能与肾上腺素受体α2B结合并拮抗。这些化合物也可能与肾上腺素受体α1B结合并拮抗。这些化合物可能在治疗中发挥作用，例如（i）降低血压和/或（ii）促进肾脏血流和/或（iii）减少或抑制钠重吸收。这些化合物也可用于治疗对降低血压有反应或预期会有反应的疾病或症状。特别描述了使用这些化合物治疗心血管和肾脏疾病。
• 1,2-Bis(trifluoromethylthiolation) of Aromatic Epoxides with AgSCF₃
  作者：Yin-Li Liu、Feng-Ling Qing、Xiu-Hua Xu

  DOI：10.1002/ejoc.201901836

  日期：2020.2.28

  An unprecedented transformation of aromatic epoxides to 1,2‐bis(trifluoromethylthiolated) products was reported. This reaction proceeded through the tandem ring‐opening and deoxytrifluoromethylthiolation processes, affording the target products in moderate to high yields.

  据报道，芳香族环氧化物前所未有地转变为1,2-双（三氟甲基硫醇化）产物。该反应通过串联开环和脱氧三氟甲基硫醇化过程进行，以中等至高收率提供目标产物。
• Process for producing organic compound epoxy resin composition, cured article obtained from the epoxy resin, and semiconductor device obtained with epoxy resin
  申请人：——

  公开号：US20040260039A1

  公开（公告）日：2004-12-23

  There are disclosed a process for producing an organic compound in the presence of a particular substituted triarylphosphine compound, particularly, a process for producing an oxyalkylene derivative at a high yield using the above compound which is very active and easy to handle, by reacting an organic epoxy compound with a carboxylic acid ester, a carboxylic acid anhydride, a sulfonic acid ester or a carbonic acid ester, and an epoxy resin composition using a particular substituted triarylphosphine compound as a curing accelerator, a cured material of the composition and a semiconductor device using the composition.

  本文披露了一种在特定取代三芳基膦化合物存在下生产有机化合物的工艺，特别是一种使用上述化合物作为催化剂，通过将有机环氧化合物与羧酸酯、羧酸酐、磺酸酯或碳酸酯反应，以及使用特定取代三芳基膦化合物作为固化促进剂的环氧树脂组合物的工艺，从而高产地生产氧代烷基衍生物，还包括该组合物的固化材料和使用该组合物的半导体器件。
• COMPOUNDS AND METHODS OF TREATING DIABETES
  申请人：Protter Andrew Asher

  公开号：US20130053367A1

  公开（公告）日：2013-02-28

  Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are antagonists of the adrenergic receptor α 2A . The compounds may also bind to and are an antagonist of the adrenergic receptor α 2B ; or the compounds are not antagonists of the adrenergic receptor α 2B and the compounds are administered in conjunction with a second agent that reduces, or is expected to reduce, blood pressure in an individual. The compounds may find use in therapy, e.g., to regulate blood glucose level, increase insulin secretion and treat diseases or conditions that are, or are expected to be, responsive to an increase in insulin production. Use of the compounds to treat type 2 diabetes is particularly described.

  本文描述了氢化吡啶并[4,3-b]吲哚、吡啶[3,4-b]吲哚和氮杂七环[4,5-b]吲哚。这些化合物可以结合并拮抗肾上腺素受体α2A。这些化合物也可以结合并拮抗肾上腺素受体α2B；或这些化合物不是肾上腺素受体α2B的拮抗剂，并且这些化合物与第二个降低或预计降低个体血压的药物一起使用。这些化合物可以用于治疗，例如，调节血糖水平、增加胰岛素分泌和治疗对增加胰岛素产生有反应或预计会有反应的疾病或病况。特别描述了使用这些化合物治疗2型糖尿病的用途。