3-(5-chloro-1H-indol-3-yl)-N-((5-chloro-1H-indol-3-yl)methyl)propanamide | 1421282-78-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(5-chloro-1H-indol-3-yl)-N-((5-chloro-1H-indol-3-yl)methyl)propanamide
• 英文别名: 3-(5-chloro-1H-indol-3-yl)-N-[(5-chloro-1H-indol-3-yl)methyl]propanamide
• CAS: 1421282-78-1
• 化学式: C₂₀H₁₇Cl₂N₃O
• 分子量: 386.28
• InChiKey: LDTHATWVRMFRTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5-氯吲哚-3-甲醛 在 platinum(IV) oxide 、 氢气 、 1-羟基苯并三唑 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 sodium hydroxide 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 35.17h， 生成 3-(5-chloro-1H-indol-3-yl)-N-((5-chloro-1H-indol-3-yl)methyl)propanamide
  参考文献：
  名称：

  Synthesis, characterization, and SAR studies of new (1H-indol-3-yl)alkyl-3-(1H-indol-3-yl)propanamide derivatives as possible antimicrobial and antitubercular agents

  摘要：

  In this article, we report herein the SAR studies of a series of (1H-indol-3-yl)alkyl-3-(1H-indol-3-yl)propanamide 10(a-j), 11(a-j). The synthesized compounds were evaluated for their preliminary in vitro antibacterial, antifungal activity and were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain. The synthesized compounds displayed interesting antimicrobial activity.

  DOI：

  10.1007/s00044-012-0451-x

文献信息

• Synthesis, characterization, and SAR studies of new (1H-indol-3-yl)alkyl-3-(1H-indol-3-yl)propanamide derivatives as possible antimicrobial and antitubercular agents
  作者：Ranjith Pakkath Karuvalam、Rajeesh Pakkath、Karickal Raman Haridas、Rathnasamy Rishikesan、Nalilu Suchetha Kumari

  DOI：10.1007/s00044-012-0451-x

  日期：2013.9

  In this article, we report herein the SAR studies of a series of (1H-indol-3-yl)alkyl-3-(1H-indol-3-yl)propanamide 10(a-j), 11(a-j). The synthesized compounds were evaluated for their preliminary in vitro antibacterial, antifungal activity and were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain. The synthesized compounds displayed interesting antimicrobial activity.