tert-butyl (4R)-2,2-dimethyl-4-(prop-2-enyliminomethyl)-1,3-oxazolidine-3-carboxylate | 951331-17-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: tert-butyl (4R)-2,2-dimethyl-4-(prop-2-enyliminomethyl)-1,3-oxazolidine-3-carboxylate
• CAS: 951331-17-2
• 化学式: C₁₄H₂₄N₂O₃
• 分子量: 268.356
• InChiKey: IJMMSRRDSFRZPN-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl (4R)-2,2-dimethyl-4-(prop-2-enyliminomethyl)-1,3-oxazolidine-3-carboxylate 、 乙烯基溴化镁 以 乙醚 为溶剂， 反应 12.0h， 以66%的产率得到tert-butyl (4R)-2,2-dimethyl-4-[1-(prop-2-enylamino)prop-2-enyl]-1,3-oxazolidine-3-carboxylate
  参考文献：
  名称：

  A new and general route to 2-pyrrolylglycine, 2-pyrrolylalanine and homo-2-pyrrolylalanine derivatives

  摘要：

  A general route to alpha-, beta- and gamma-pyrrole-branched alpha-amino acid derivatives has been developed, which featured a one-pot ring-closing metathesis and aromatization reaction as the key step. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.06.021
• 作为产物：
  描述：

  3-反-溴碳-2,2'-二甲基氧酸酯 、 丙烯胺 以 二氯甲烷 为溶剂， 反应 24.0h， 以95%的产率得到tert-butyl (4R)-2,2-dimethyl-4-(prop-2-enyliminomethyl)-1,3-oxazolidine-3-carboxylate
  参考文献：
  名称：

  A new and general route to 2-pyrrolylglycine, 2-pyrrolylalanine and homo-2-pyrrolylalanine derivatives

  摘要：

  A general route to alpha-, beta- and gamma-pyrrole-branched alpha-amino acid derivatives has been developed, which featured a one-pot ring-closing metathesis and aromatization reaction as the key step. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.06.021

文献信息

• A new and general route to 2-pyrrolylglycine, 2-pyrrolylalanine and homo-2-pyrrolylalanine derivatives
  作者：Kaushik Sarkar、Sovan K. Singha、Shital K. Chattopadhyay

  DOI：10.1016/j.tetasy.2009.06.021

  日期：2009.8

  A general route to alpha-, beta- and gamma-pyrrole-branched alpha-amino acid derivatives has been developed, which featured a one-pot ring-closing metathesis and aromatization reaction as the key step. (c) 2009 Elsevier Ltd. All rights reserved.