sakuranetin | 17784-36-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: sakuranetin
• 英文别名: (R)-5-hydroxy-2-(4-hydroxy-phenyl)-7-methoxy-chroman-4-one；(R)-5-Hydroxy-2-(4-hydroxy-phenyl)-7-methoxy-chroman-4-on；(2R)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-2,3-dihydrochromen-4-one
• CAS: 17784-36-0
• 化学式: C₁₆H₁₄O₅
• 分子量: 286.284
• InChiKey: DJOJDHGQRNZXQQ-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  sakuranin 在 甲醇 、 硫酸 作用下， 生成 sakuranetin
  参考文献：
  名称：

  Hishida, Nippon Kagaku Zasshi, 1958, vol. 79, p. 709,717

  摘要：

  DOI：

文献信息

• Compounds from an extract of Artemisia and methods for treating disorders
  申请人：Ribnicky M. David

  公开号：US20070224301A1

  公开（公告）日：2007-09-27

  This invention comprises an extract of Artemisia dracunculus that can be used for the treatment and prevention of diabetes, diabetic complications, metabolic syndrome and other comorbidities that share the underlying commonality of insulin resistance. The invention includes the identity of six compounds from the extract that contribute to the activity of the extract by inhibiting protein tyrosine phosphatase-1B (PTP-1B) activity, phosphoenolpyruvate carboxykinase (PEPCK) gene expression or aldose reductase activity (ALR2). The compounds include 4,5-Di-O-caffeoylquinic acid, davidigenin, 6-demethoxycapillarisin, 2′,4-dihydroxy-4′-methoxydihydrochalcone, 2′,4′-dihydroxy-4-methoxdihydrochalcone and sakuranetin.
• Hishida, Nippon Kagaku Zasshi, 1958, vol. 79, p. 709,717
  作者：Hishida

  DOI：——

  日期：——