4-[2-(2-chloroethoxy)ethoxy]-salicylaldehyde | 1172635-13-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[2-(2-chloroethoxy)ethoxy]-salicylaldehyde
• 英文别名: 4-[2-(2-Chloroethoxy)ethoxy]-2-hydroxybenzaldehyde
• CAS: 1172635-13-0
• 化学式: C₁₁H₁₃ClO₄
• 分子量: 244.675
• InChiKey: SMWLFGDHKRBIBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(2-chloroethoxy)ethyl tosylate 、 2,4-二羟基苯甲醛 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 48.0h， 以50%的产率得到4-[2-(2-chloroethoxy)ethoxy]-salicylaldehyde
  参考文献：
  名称：

  Regioselective alkylation of hydroxysalicylaldehydes

  摘要：

  Schiff-base ligands are often used as backbone ligands for mono- and dinuclear complexes that serve as catalysts during aerobic oxidation reactions. However, their water Solubility is low and limits their applicability as catalysts to transform highly water-soluble biomolecules, such as carbohydrates or amino alcohols. A new method to regioselectively incorporate water solubility-promoting polyethylene glycol side chains into a frequently used aldehyde building block of Schiff-base ligands has been developed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.03.104

文献信息

• Regioselective alkylation of hydroxysalicylaldehydes
  作者：Moses G. Gichinga、Susanne Striegler

  DOI：10.1016/j.tet.2009.03.104

  日期：2009.6

  Schiff-base ligands are often used as backbone ligands for mono- and dinuclear complexes that serve as catalysts during aerobic oxidation reactions. However, their water Solubility is low and limits their applicability as catalysts to transform highly water-soluble biomolecules, such as carbohydrates or amino alcohols. A new method to regioselectively incorporate water solubility-promoting polyethylene glycol side chains into a frequently used aldehyde building block of Schiff-base ligands has been developed. (C) 2009 Elsevier Ltd. All rights reserved.