9H-benzo[f]imidazo[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine | 1450807-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 9H-benzo[f]imidazo[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine
• 英文别名: 2,3,4,8,11-pentazatetracyclo[11.4.0.02,6.08,12]heptadeca-1(17),3,5,9,11,13,15-heptaene
• CAS: 1450807-34-7
• 化学式: C₁₂H₉N₅
• 分子量: 223.237
• InChiKey: UBXVCQWXEZEDFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  48.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  邻硝基苯甲醛 在 六甲基磷酰三胺 、 indium(III) chloride 、 sodium azide 、 ammonium acetate 作用下， 以 甲醇 、 水 为溶剂， 反应 72.0h， 生成 9H-benzo[f]imidazo[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine
  参考文献：
  名称：

  Facile One-Pot Assembly of Imidazotriazolobenzodiazepines via Indium(III)-Catalyzed Multicomponent Reactions

  摘要：

  An operationally simple, one-pot multicomponent reaction has been developed for the assembly of 9H-benzo[f]imidazo[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepines adorned with three diversification points via an atom-economical transformation incorporating alpha-diketones, o-azidobenzaldehydes, propargylic amines, and ammonium acetate. This process involves tandem InCI3-catalyzed cyclocondensation and intramolecular azide-alkyne 1,3-dipolar cycloaddition reactions; optimization data, substrate scope, and mechanistic insights are discussed.

  DOI：

  10.1021/ol402045h

文献信息

• Facile One-Pot Assembly of Imidazotriazolobenzodiazepines via Indium(III)-Catalyzed Multicomponent Reactions
  作者：Huy H. Nguyen、Teresa A. Palazzo、Mark J. Kurth

  DOI：10.1021/ol402045h

  日期：2013.9.6

  An operationally simple, one-pot multicomponent reaction has been developed for the assembly of 9H-benzo[f]imidazo[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepines adorned with three diversification points via an atom-economical transformation incorporating alpha-diketones, o-azidobenzaldehydes, propargylic amines, and ammonium acetate. This process involves tandem InCI3-catalyzed cyclocondensation and intramolecular azide-alkyne 1,3-dipolar cycloaddition reactions; optimization data, substrate scope, and mechanistic insights are discussed.